Abstract: In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
Type:
Grant
Filed:
June 25, 2008
Date of Patent:
April 19, 2011
Assignee:
Kyowa Hakko Kirin Co., Ltd.
Inventors:
James M. Robl, Yoshimi Kuroiwa, Poothappillai Kasinathan, Isao Ishida, Kazuma Tomizuka