Patents Represented by Attorney Clayton, Howarth & Cannon, P.C.
  • Patent number: 8326662
    Abstract: Example embodiments provide program products, systems, and associated methods of presenting a seller with a graphical representation of demand for a potential product listing so that the seller can intelligently price and position the product. A website server associated with a website of product listings captures in a database product preference criteria for a consumer, including, for example, price information. The website server aggregates the captured product preference criteria for a plurality of consumers and determines an imputed consumer demand for a potential product listing. The website server displays on a display device associated with a computer of a seller a multi-dimensional graph of demand for the potential product listing so that the seller can gauge market demand prior to listing a product for sale. Embodiments further include two-dimensional graphs plotting demand versus price, contour lines for the demand imposed on pricing graphs, and color-coded demand heat maps.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: December 4, 2012
    Assignee: Overstock.com, Inc.
    Inventors: Patrick Michael Byrne, Geoffrey Russell Atkinson
  • Patent number: 8263664
    Abstract: Mixed micelles containing poly(L-histidine-co-phenylalanine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: September 11, 2012
    Assignee: University of Utah Research Foundation
    Inventors: Dongin Kim, Zhonggao Gao, Eun Seong Lee, You Han Bae
  • Patent number: 8215488
    Abstract: A packaging assembly is disclosed. The packaging assembly is easily assembled and disassembled for convenient use and provides suspension of an enclosed article by way of an arched structure providing protection from impact, shock and vibration.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: July 10, 2012
    Assignee: Ingram Micro Inc.
    Inventor: Kimberly Klos
  • Patent number: 8214804
    Abstract: A system and method to efficiently and randomly place users into a test group associated with a test running on a website being hosted on a server is disclosed. When a user first accesses the website, a random value is transmitted to the user in such a manner that the random value is stored in a computer-readable memory local to the user. Each subsequent time the user accesses the website, the random value is returned to the server from the user. The server may then place the user into a test group for a test to which the user will be exposed on the website based upon the result of an operation that includes the random value received from the user and a unique test value previously associated with the test.
    Type: Grant
    Filed: January 14, 2008
    Date of Patent: July 3, 2012
    Assignee: Overstock.com, Inc.
    Inventor: Ian B. Robertson
  • Patent number: 8197393
    Abstract: A resistance exercise apparatus is provided which, includes structures for receiving a body extremity of a user, the means for receiving a body extremity subject to a force provided by the body extremity, structures for maintaining the means for receiving a body extremity in a predefined plane during movement; and resistance providing devices to impose resistance against, the movement of the body extremity. Versions of the apparatus may positioned on a floor, on a wall, or be free standing. Various embodiments of the invention are particularly suited to provide range-of-motion exercises for legs, arms, and hands of the user for both recreational strengthening and physical therapy applications.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: June 12, 2012
    Assignee: Isopulse, Inc.
    Inventor: Larry Shane Harmon
  • Patent number: 8168379
    Abstract: The present invention discloses using SPR technology to simultaneously and qualitatively detect different HPV genotypes. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HPV specific DNA probes used for the detection of different HPV genotypes.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: May 1, 2012
    Assignee: CMED Technologies Ltd.
    Inventors: Zhong Chen, Ning Liu, Huawei Yang, Hongtao Zhang, Yuye Yang, Yuyang Hu, Sheng Wang, Qingmei Ma
  • Patent number: 8158343
    Abstract: This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of respiratory tract viruses-related immunological markers in a serum sample, which can be used for the diagnosis of respiratory tract infections. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of representative antigens used to detect the respective respiratory tract viruses-related immunological markers (antibodies) in blood for the diagnosis of respiratory tract infections.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: April 17, 2012
    Assignee: CMED Technologies Ltd.
    Inventors: Zhong Chen, Ning Liu, Yancun Li
  • Patent number: 8158342
    Abstract: This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HIV related antibodies in a serum sample for the diagnosis of HIV infection. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HIV related antigens used for the diagnosis of HIV infection.
    Type: Grant
    Filed: August 27, 2007
    Date of Patent: April 17, 2012
    Assignee: CMED Technologies Ltd.
    Inventors: Zhong Chen, Ning Liu, Yancun Li
  • Patent number: 8158440
    Abstract: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of thyroid hormones and related antibodies in a serum sample, which can be used to evaluate thyroid functions and to diagnose thyroid diseases. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies and antigens used for the detection of respective thyroid hormones and related antibodies in a serum sample.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: April 17, 2012
    Assignee: CMED Technologies Ltd.
    Inventors: Zhong Chen, Ning Liu, Yancun Li
  • Patent number: 8153154
    Abstract: An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with plasmid DNA. ABP is biodegraded under reducing conditions, such as the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: April 10, 2012
    Assignee: University of Utah
    Inventors: Sung Wan Kim, Tae-il Kim
  • Patent number: 8153445
    Abstract: This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of infectious agent related antibodies and/or antigens in a serum sample, which can be used to screen for infectious agents in blood. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the screening of infectious agents in blood.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: April 10, 2012
    Assignee: CMED Technologies Ltd.
    Inventors: Zhong Chen, Ning Liu, Yancun Li
  • Patent number: 8153155
    Abstract: An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with siRNA. ABP is biodegraded under reducing conditions, such as in the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity. ABP is an effective delivery vehicle for gene silencing with siRNA and may be used for treating cancer.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: April 10, 2012
    Assignee: University of Utah
    Inventors: Sun Hwa Kim, Ji Hoon Jeong, Tae-il Kim, Sung Wan Kim, David A. Bull
  • Patent number: 8119350
    Abstract: The present invention discloses using SPR technology to detect MM related genomic imbalances in bone marrow samples. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of DNA markers used for the identification of MM related genomic imbalances in bone marrow samples is also disclosed.
    Type: Grant
    Filed: August 23, 2007
    Date of Patent: February 21, 2012
    Assignee: CMED Technologies Ltd
    Inventors: Zhong Chen, Ning Liu
  • Patent number: 8114682
    Abstract: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different sex hormones in a serum sample, which can be used to evaluate different clinical situations. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of representative sex hormones in a serum sample.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: February 14, 2012
    Assignee: CMED Technologies Ltd.
    Inventors: Zhong Chen, Ning Liu, Yancun Li
  • Patent number: 8110408
    Abstract: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of diabetes related immunological makers in a serum sample, which can be used to diagnose and/or early diagnose diabetes as well as to predict the onset risk of diabetes in first-degree relatives. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the detection of respective diabetes related immunological makers in a serum sample.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: February 7, 2012
    Assignee: CMED Technologies Ltd.
    Inventors: Zhong Chen, Ning Liu, Yancun Li
  • Patent number: 8110409
    Abstract: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different liver fibrosis-associated serum biomarkers in a serum sample, which can be used for the diagnosis of liver fibrosis. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of liver fibrosis-associated serum biomarkers for the diagnosis of liver fibrosis.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: February 7, 2012
    Assignee: CMED Technologies Ltd.
    Inventors: Zhong Chen, Ning Liu, Yancun Li
  • Patent number: 8088753
    Abstract: Heparin conjugates and methods of making and use thereof are disclosed. An illustrative heparin conjugate includes a composition wherein a bile acid is bonded to heparin through the 3-carbon of the bile acid. A spacer may be interposed between the bile acid and the heparin. Another embodiment includes a targeting moiety bonded to the heparin-bile acid conjugate through a spacer. Another illustrative heparin conjugate includes heparin covalently bonded to a sulfonated moiety, such as a naphthalene trisulfonate residue. A method of treating cancer includes administering a heparin conjugate to an individual in need thereof.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: January 3, 2012
    Assignee: Mediplex Corporation, Korea
    Inventors: Youngro Byun, E Sak Lee, Ok-cheol Jeon, Sang Yoon Kim, Rang-Woon Park
  • Patent number: 8077378
    Abstract: A calibration method for a grating light modulator includes calibrating light reflective ribbons on the modulator on a pixel-by-pixel basis. The method further includes performing a dark-state calibration and a bright-state calibration for each pixel. Once completed, the results of the dark-state calibration and the bright-state calibration may be combined to ensure a smooth transition between a dark state and a bright state for each pixel.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: December 13, 2011
    Assignee: Evans & Sutherland Computer Corporation
    Inventors: Michael Wayne Bass, Dennis F. Elkins, Bret D. Winkler
  • Patent number: 8065760
    Abstract: This invention presents a foldable cot. The foldable cot includes a foldable frame and a flexible sheet having a generally rectangular shape. The peripheral portions of the flexible sheet are secured to the foldable frame. The foldable frame has two-pairs of hingedly connected longitudinal bars, which allows the foldable frame to be folded in a longitudinal direction. A middle support structure is mounted to the hinge connectors. The middle support structure includes a pair of crossbars having a general X-shape. Upper ends of the crossbars are pivotably connected to the hinge connectors. There is provided a pair of vertical poles connecting the upper ends and lower ends of the crossbars, respectively. The vertical poles are extendible between a retracted position and an extended position, which allows the X-shaped crossbars to have a scissors-like motion so that the foldable frame can be folded in a transverse direction.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: November 29, 2011
    Assignee: Active Lifestyle & Products & Services, Inc.
    Inventor: Adam N. Brune
  • Patent number: 8058256
    Abstract: A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: November 15, 2011
    Assignee: University of Utah Research Foundation
    Inventors: Won Jong Kim, Sung Wan Kim