Abstract: Controlled release powder insufflation formulations are disclosed. The powder formulation includes cohesive composites of particles containing a medicament and a controlled release carrier which preferably includes one or more polysaccharide gums of natural origin.
Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.
Type:
Grant
Filed:
February 27, 1996
Date of Patent:
December 15, 1998
Assignee:
Euro-Celtique, S.A.
Inventors:
Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Treavor John Knott, Joanne Heafield, Deborah Challis
Abstract: Described are cloning and sequencing of genes encoding novel isoforms (paxillins .beta. and .gamma.) of focal adhesion protein paxillin. According to the present invention, there is provided a novel gene for an isoform of focal adhesion protein paxillin. This gene is useful medical applications such as diagnosis of progress of cancer malignancy, development of a drug (cancer treatment) for preventing the metastasis and infiltration of cancer cells, etc.
Type:
Grant
Filed:
July 8, 1997
Date of Patent:
September 22, 1998
Assignee:
Japan Science and Technology Corporation
Abstract: A controlled release pharmaceutical composition for oral administration in humans or animals, comprising a controlled release matrix comprising a pharmaceutically acceptable sodium alginate, a pharmaceutically acceptable water swellable polymer, a pharmaceutically acceptable C.sub.2 -C.sub.50 edible hydrocarbon derivative having a melting point ranging from 25.degree. C. and 90.degree. C. and a pharmaceutically acceptable divalent salt selected from the group consisting of an iron salt, a zinc salt, a magnesium salt, an aluminum salt and a calcium salt and mixtures of any of the foregoing and a therapeutically active agent to be administered and a lubricant or lubricants suitable for forming the composition into tablets or capsules and methods of making and using the same.
Abstract: Controlled release powder insufflation formulations are disclosed. The powder formulation includes cohesive composites of particles containing a medicament and a controlled release carrier which preferably includes one or more polysaccharide gums of natural origin.