Abstract: Embodiments of the present invention relate to p110 soluble EGFR (p110 sEGFR) peptides and nucleic acid sequences. Antibodies, methods of detection, kits, and expression vectors for p110 sEGFR are disclosed. In addition, assays on biological samples for determining and evaluating risk assessment and cancer prevention, screening and early detection, diagnosis, prognosis, theragnosis, monitoring of responsiveness to treatment, and monitoring of disease progression, recurrence, or metastasis of a cancer, are disclosed. In examples, a lower p110 sEGFR concentration adjusted for demographical and physiological variables and other biomarkers is associated with cancer. Therapeutics and methods of treating a cancer related to p110 sEGFR also are embodied herein.

Abstract: A method and apparatus for video retrieval and cueing that automatically detects human faces in the video and identifies face-specific video frames so as to allow retrieval and viewing of person-specific video segments. In one embodiment, the method locates human faces in the video, stores the time stamps associated with each face, displays a single image associated with each face, matches each face against a database, computes face locations with respect to a common 3D coordinate system, and provides a means of displaying: 1) information retrieved from the database associated with a selected person or people, 2) path of travel associated with a selected person or people 3) interaction graph of people in video, 4) video segments associated with each person and/or face. The method may also provide the ability to input and store text annotations associated with each person, face, and video segment, and the ability to enroll and remove people from database.

Abstract: The invention concerns a method of creating an XML document on a web browser. The method according to the invention comprises the steps of: receiving data input from a web browser; duplicating a source XML document stored in advance, the source XML document including predefined structures and predetermined source data; replacing the source data included in the duplicated XML document by the received input data; and storing the XML document resulted in the above replacing step as a new XML document. According to the invention, an ordinary user can easily create XML documents in a given form, e.g., resumes, commercial agreement sheets, official documents, etc., using only current web browsers widely used, without a specified XML editor.

Abstract: The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient.

Abstract: The claimed carpet cleaning apparatus incorporates recesses in a rigid surface of a roller or in a rigid disk. As the roller or disk rotates or is moved across the soft surface to be cleaned, the roller or disk presses downward on the soft surface and compresses it. The soft surface decompresses to the original position when the soft surface is in contact with a surface of a recess and recompresses when the roller or disk presses downward again. The compression, decompression, and recompression, preferably in combination with a cleaning compound, provide the mechanical action necessary for removal of foreign material.

Abstract: The invention provides a magnetic connector for use between members to magnetically connect members such as members between eyewear. Magnetic connector has first and second magnets positioned in or on first and second eyewear members, respectively. Magnets are positioned substantially parallel to each other in a plane and rotate about an axis. A magnetic field of attraction is created between magnets when magnets are in sufficient proximity to each other thereby substantially connecting members. When magnets disengage or fall out of alignment due to force or pressure against members, magnets disengage and allow members to break away without damage.

Abstract: The invention is a system that reviews, approves, and implements updates to a primary database that houses a business's chargeable items. A duplicate database has a duplicate of each data entry in the primary database. Prior to implementation, the update is reviewed for compliance with regulatory and local standards and preapproved updates by using the duplicate database as a point of reference. The management service may revise the update before implementing the update into the primary database. Preferably any update that is implemented into the primary database is validated to confirm that the implemented update matches the approved update.

Abstract: Regulation of sErbB3 isoforms in methods of regulating heregulin activity or ErbB receptor activities is disclosed. Cancer therapeutics and methods of therapeutically treating cancer comprising sErbB3 are also disclosed. Detection of sErbB3 in biological samples for risk assessment and prevention, screening, diagnosis, prognosis, theragnosis, evaluation of responsiveness to treatment, and/or monitoring of disease progression, recurrence, or metastasis of a cancer is disclosed as well. In examples, sErbB3 nucleic acid sequences, polypeptides, molecular probes, and antibodies are useful agents for regulation, expression, detection, and cancer therapeutics related to sErbB3.

Abstract: Regulation of sErbB3 isoforms in methods of regulating heregulin activity or ErbB receptor activities is disclosed. Cancer therapeutics and methods of therapeutically treating cancer comprising sErbB3 are also disclosed. Detection of sErbB3 in biological samples for risk assessment and prevention, screening, diagnosis, prognosis, theragnosis, evaluation of responsiveness to treatment, and/or monitoring of disease progression, recurrence, or metastasis of a cancer is disclosed as well. In examples, sErbB3 nucleic acid sequences, polypeptides, molecular probes, and antibodies are useful agents for regulation, expression, detection, and cancer therapeutics related to sErbB3.

Abstract: A packaging container with a clamping base and an attachable protective cap serves for a unilateral, clamping or holding of a tool, an instrument, or another longitudinal object, where the clamping base comprises a clamping holder with a plurality of springy clamping jaws fastened on one side which define a nearly centric, central clamping reception, in which clamping reception the tool is inserted and held clampingly. In order to achieve that the insertion force to be applied is low when the packaging container is equipped, however, a high clamping force is given with the protective cap attached. The protective cap abuts against the outside circumference of the clamping jaws when it is attached to the clamping base and prestresses said clamping jaws in direction of the clamping reception.

Abstract: The present invention relates to the discovery of soluble isoforms of an Epidermal Growth Factor Receptor, or sErbB 1/HER1 variants, the provision of the sequences of nucleic acids encoding these isoforms, purified recombinant proteins, novel antibodies specific for these isoforms, and the use of immunoassay and gene expression assay techniques to measure the concentration of these gene products in a patient biological sample. The present invention also provides methods for determining the presence of an ovarian carcinoma in the patient by assaying the concentration of soluble EGFR/ErbB1 variants in a biological sample from a patient.

Abstract: A computer-assisted method for an automatic savings plan. The method includes calculating a savings amount from an indication of a time of transaction for each of a plurality of transactions. The method also includes transferring the savings amount from a first account to at least one receiving account.

Abstract: The present invention discloses a method using human soluble ErbB3, for example p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention also discloses p85-sErbB3 binding to heregulin with an affinity comparable to that of full-length ErbB3, and competitively inhibiting high affinity heregulin binding to ErbB2/ErbB3 heterodimers on the cell surface of breast carcinoma cells. The present invention also uses p85-sErbB3 to inhibit heregulin-induced phosphorylation of ErbB2, ErbB3, and ErbB4 in cells, as a negative regulator of heregulin-stimulated signal transduction, and as a block for cell growth. The present invention is also directed to nucleic acids and expression vectors encoding p85-sErbB3, host cells harboring such expression vectors, and methods of producing the protein. The present invention discloses a method of therapeutically treating human malignancies associated with heregulin-mediated cell growth such as breast and prostate cancer.

Abstract: A container comprising a snap-in closure disposed between an upper part and a lower part of the container, the snap-in closure having a relatively strong holding or locking force and able to be opened relatively easily. The snap-in closure comprises a snap-in tab constructed out of the wall of one part of the container and detached along three sides, with a snap-in key disposed at the upper free end of the said snap-in closure and able to engage in a coordinated snap-in slit at the opposite container part.

Abstract: In an embodiment, the present invention provides a device that identifies cardiovascular dysfunction of a subject. The claimed device comprises a controller, a transducer, and a processor. The controller initiates collection of a plurality of data related to a physiological condition. The transducer collects data over a plurality of cycles and transfers the data to the processor, which reduces the received data signal into an output using a novel formula. In an example the data correlate with data that are directly related to cardiovascular dysfunction but that are of limited use.

Abstract: An individual packaging unit for precision tools that includes a base part with a receiving opening for receiving a shaft of a breakable object loosely and with clearance. A protective part with a groove-shaped receiving device for anchoring the precision tool is disposed on the base part in a way to be pivotable, said protective part comprising at least two functionally separate portions wherein one portion is a clamping part, and the other portion is a receiving part. The individual packaging unit is closed with a push-on protective cap that is pushed in a longitudinal direction to engage the base part. The clamping part clamps the precision tool when the protective cap is pushed onto the individual packaging unit.

Abstract: An indexer is used on or in combination with a sheet bending brake to cut or bend a piece of sheet metal at a predetermined location without having to make pre-measurements and marks. The indexer comprises a scale and a rotable shaft having a handle. A first bending arm with a gauge and opposed second and third bending arms are connected to the shaft. Second and third arms each have a stop that positions the sheet metal to make a cut or bend at the predetermined location. An example of a method of using the indexer is also discussed.