Abstract: The present invention provides very high affinity antibodies, or antigen-binding fragments thereof, that neutralize mature human TGF-?1, TGF-?2, and TGF-?3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.
Type:
Grant
Filed:
December 20, 2006
Date of Patent:
February 24, 2009
Assignee:
Eli Lilly and Company
Inventors:
Bryan Edward Jones, James D. Pancook, Scott William Rowlinson