Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
Type:
Grant
Filed:
April 15, 2005
Date of Patent:
October 23, 2012
Assignees:
Alkernnes Pharma Ireland Limited, Amylin Pharmaceuticals, Inc.
Inventors:
Steven G. Wright, Troy Christensen, Thean Yeoh, Michael E. Rickey, Joyce M. Hotz, Rajesh Kumar, Henry R. Costantino, Christine Smith, David M. Lokensgard, Mark Fineman, John Ong
Abstract: A liquid suspension comprising an antifungally effective amount of the micronized compound represented by the chemical structural formula I: at least one thickening agent, a non-ionic surfactant, and a pharmaceutically acceptable liquid carrier is disclosed.
Type:
Grant
Filed:
June 15, 2011
Date of Patent:
September 11, 2012
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
Stefan Sharpe, Joel Sequeira, David Harris, Shashank Mahashabde
Abstract: Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-?-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
Type:
Grant
Filed:
September 25, 2008
Date of Patent:
July 17, 2012
Assignees:
Merck Sharp & Dohme Corp., Scynexis, Inc.
Inventors:
James M. Balkovec, Phieng Siliphaivanh, Frances A. Bouffard, Roland A. Bouffard, legal representative, Michael R. Peel, Weiming Fan, Ahmed Mamai, Sarah Dimick Gray
Abstract: This invention discloses a wood preservative composition for the supplemental or remedial treatment of in-service poles, posts, piling, cross ties and other wooden structures. The wood preservative composition comprises copper 8-hydroxyquinolate (oxine copper) in combination with a boron compound or a fluoride compound.
Type:
Grant
Filed:
February 11, 2008
Date of Patent:
July 17, 2012
Assignee:
Osmose, Inc.
Inventors:
Jun Zhang, Douglas J. Herdman, Richard J. Ziobro
Abstract: An improved expandable broadhead with rear deploying blades. The rear deploying blades deploy reliably upon impact of the blades with a target. The expandable broadhead resists deflection by the target regardless of the angle of entry. Consequently, the present expandable broadhead maximizes kinetic energy on impact and increases the probability of substantial penetration into the target.
Type:
Grant
Filed:
July 1, 2010
Date of Patent:
June 12, 2012
Assignee:
Out RAGE, LLC
Inventors:
Larry R. Pulkrabek, William Edward Pedersen, Bruce Barrie
Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Type:
Grant
Filed:
December 14, 2010
Date of Patent:
May 29, 2012
Assignee:
Alkermes Pharma Ireland Limited
Inventors:
Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar
Abstract: Novel derivatives of enfumafungin are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-?-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.
Type:
Grant
Filed:
August 7, 2009
Date of Patent:
May 29, 2012
Assignees:
Merck Sharp & Dohme Corp., Seynexis, Inc.
Inventors:
Mark L. Greenlee, Robert Wilkening, James Apgar, Donald Sperbeck, Kenneth J. Wildonger, Dongfang Meng, Dann L. Parker, Jr., Gregory J. Pacofsky, Brian H. Heasley, Ahmed Mamai, Kingsley Nelson
Abstract: The invention relates to the use of a polypeptide that comprises i) a first portion comprising the part of human Fc that binds to CD64, and ii) a second portion comprising one or more heterologous T cell epitopes for stimulating a cytotoxic T cell response. The polypeptide may be an antibody that may be used to stimulate a cytotoxic T cell response against pathogens and tumor cells in patients in need of such treatment.
Type:
Grant
Filed:
August 18, 2010
Date of Patent:
May 29, 2012
Assignees:
Scancell Limited, Cancer Research Technology Limited
Inventors:
Linda Gillian Durrant, Tina Parsons, Adrian Robins
Abstract: A method for the preparation of a composite product, as well as the composite product. The composite product comprises at least two layers. At least one of the layers is of wood or another cellulose-containing material. The process comprises differentially treating the layers prior to, during, or after the lamination of the layers into a composite product.
Abstract: The present invention provides wood preservative and flame retardant compositions having low leachability comprising micronized boron compounds and, optionally, one or more organic biocides which may be micronized. Also provided is a method for applying the composition to wood and wood products comprising impregnating the wood with the composition.
Type:
Grant
Filed:
January 21, 2010
Date of Patent:
May 1, 2012
Assignee:
Osmose, Inc.
Inventors:
Jun Zhang, Wenjin Zhang, Robert M. Leach
Abstract: The present invention is directed, in certain embodiments, to methods of preserving wood comprising the steps of providing an aqueous wood preservative slurry comprising a plurality of injectable particulates comprising at least 20% by weight of a sparingly soluble copper salt, wherein the first particulates have a d96 of about 1 micron or less, a d99 of about 1.5 microns or less, and a d50 of greater than 0.02 micron, and injecting the aqueous wood preservative slurry into wood.
Abstract: The invention relates to compositions and methods for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein a biologically active polypeptide, and a corticosteroid to modify the release profile and provide increased bioavailability.
Type:
Grant
Filed:
November 6, 2008
Date of Patent:
March 6, 2012
Assignee:
Alkermes Pharma Ireland Limited
Inventors:
Henry R. Costantino, Joyce M. Hotz, James R. Dasch, M. Gary I. Riley, Paul A. Burke, Susan A. Steitz-Abadi, Stephen E. Zale
Abstract: An apparatus and method for providing security disclosure information in at least two aligned formats, the apparatus including security disclosure data in an audio format, a processor for receiving the audio security disclosure data and for inserting a first marker therein and said processor for creating a text from the audio security disclosure data and for inserting a second marker in the text in a position corresponding to a location of the first marker in the audio security disclosure data.
Type:
Grant
Filed:
March 11, 2004
Date of Patent:
June 21, 2011
Assignee:
Thomson Financial LLC
Inventors:
Andre Lavoie, Mayer M. Danzig, Roland C. Beaulieu
Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Type:
Grant
Filed:
March 20, 2009
Date of Patent:
January 25, 2011
Assignee:
Alkermes, Inc.
Inventors:
Michael E. Rickey, J. Michael Ramstack, Rajesh Kumar