Abstract: The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.

Abstract: A target type thrust reverser is provided for reversing the thrust of jet engines, particularly on aircraft. The thrust reverser preferably has a plurality of doors that occupy a stowed position about the nozzle of the jet engine until deployed. In the stowed position, the doors are out of the exhaust stream of the jet engine. The doors are mounted to pivot joints on the rear portions of the doors. To deploy the thrust reverser, actuators connected to the pivot joints cause the pivot joints to translate linearly aft, and link rods attached to the forward portions of the doors cause the doors to pivot about the sliding pivot joints. In this manner, the distance between the doors and the engine exhaust nozzle is minimized during deployment, which enables significant weight savings due to reduced loads and fewer parts. A novel lock is also provided for simultaneously locking the thrust reverser doors and the actuators.

Abstract: This invention is directed to an improved bag-in-box apparatus for containing and dispensing liquids such as beverages. The interior surface of the bottom of the box (20) is preferably sloped downward toward the spout (12) of the bag (10) such that gravity helps feed the liquid toward the spout (12). In lieu of or in conjunction with slopes, the interior bottom surface of the box (120, 130, 150, 140, 160) may have terraces (34), curves (132, 134), corrugations (152), fan-like ridges (142), or beams (162). The present invention thereby reduces the amount of residual liquid as the liquid is withdrawn from the bag (10) without the need for an evacuation strip or a special slanted rack. Although the primary intended application of the present invention is in bag-in-box packages for containing and dispensing beverages, this invention may also be used to advantage in other liquid dispensing applications.