Patents Represented by Attorney Craig D. Siman

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  • N-demethylation of N-methyl morphinans
    Patent number: 7671204
    Abstract: The present invention provides a synthetic process for the N-demethylation of N-methyl morphinans. In particular, the invention provides improved synthetic methods for the preparation of N-demethylated morphinan compounds that may be employed as starting materials, for example, commonly available N-methyl opiates such as oripavine and thebaine, and C(3)-protected hydroxy derivatives of oripavine.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: March 2, 2010
    Assignee: Mallinckrodt Inc.
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich