Abstract: Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs) or interleukin 10 (IL-10), as well as antibodies which specifically bind IL-10, are provided. These proteins, and antibodies, may be used to treat various disease states associated with cytokine imbalances.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
May 29, 2001
Assignee:
Schering Corporation
Inventors:
Timothy R. Mosmann, Kevin W. Moore, Martha W. Bond, Paulo J. M. Vieira
Abstract: Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIF's, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-&ggr;.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
April 17, 2001
Assignee:
Schering Corporation
Inventors:
Timothy R. Mosmann, Kevin W. Moore, Martha W. Bond, Paulo J. M. Vieira
Abstract: Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-&ggr;.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
March 27, 2001
Assignee:
Schering Corporation
Inventors:
Timothy R. Mosmann, Kevin W. Moore, Martha W. Bond, Paulo J. M. Vieira