Patents Represented by Attorney D. J. Perrella

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  • Therapeutic derivatives of diphosphonates
    Patent number: 6333424
    Abstract: Compounds having utility in achieving the foregoing objects of the invention are prepared by reacting a 2,2-bis-(disubstituted-phosphoryl)-ethylsulfanyl-acetic acid compound with a pharmaceutically active chemical entity effective to treat the underlying disease state or with non-pharmaceutical entities such as pesticides, insecticides, fungicides or poisons for vermin.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: December 25, 2001
    Assignee: Eliza Nor Biopharmaceuticals, Inc.
    Inventors: Pal Herczegh, John F. Hartmann, Arpad Kovacs, Ferenc J. Sztaricskai, Miklos Hornyak
  • Diagnostic assay for localizing H. pylori
    Patent number: 5955054
    Abstract: An object of the present invention is to provide a non-invasive method to detect H. pylori within the stomach and duodenum. Another object is to provide a non-invasive method to localize this organism within the stomach and duodenum. A further object is to provide a kit containing the reagents for carrying out the diagnostic assay of the present invention.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: September 21, 1999
    Inventor: John F. Hartmann
  • Monotherapy of peptic ulcers and gastritis
    Patent number: 5900410
    Abstract: The present invention is directed to compositions, methods and kits for treating areas of H. pylori infection in the GI tract. The active ingredient is an antibiotic-bisphosphonate adduct wherein the antibiotic is selected for its ability to eradicate H. pylori. Other components include a salt of a divalent cation that is insolubilized in vivo at alkaline pH, and optionally a substrate from which the enzyme urease liberates NH.sub.3.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: May 4, 1999
    Inventor: John F. Hartmann
  • Therapeutic derivations of diphosphonates
    Patent number: 5880111
    Abstract: Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, and infectious urinary tract stones, are obtained by combining chemically a diphosphonate compound with a therapeutic agent effective against the foregoing diseases.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 9, 1999
    Inventors: Dan Farcasiu, John F. Hartmann, Pal Herczegh, Ferenc J. Sztaricskai
  • Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
    Patent number: 5668117
    Abstract: Therapeutic compositions comprising an effective amount of at least one carbonyl trapping agent alone or in combination with a therapeutically effective of a co-agent or medicament are disclosed. The compositions are used to treat a mammal suffering from a neurological disease characterized by covalent bond crosslinking between the nerve cells, other cellular structures and their intracellular and extracellular components, with disease induced carbonyl-containing aliphatic or aromatic hydrocarbons present in mammals.
    Type: Grant
    Filed: June 29, 1993
    Date of Patent: September 16, 1997
    Inventor: Howard K. Shapiro
  • Ball kicker
    Patent number: 4523756
    Abstract: A ball kicker for an automatic pin setting machine is formed of a semi-hard rubbery material having a plurality of vertical grooves.
    Type: Grant
    Filed: May 22, 1980
    Date of Patent: June 18, 1985
    Inventor: Thomas M. Camilleri
  • Pin guide arm
    Patent number: 4340221
    Abstract: A pin guide arm for an automatic pinsetter bowling machine is provided with locking guide means and flexible mounting means to lead bowling pins from the pin wheel to the turnaround pan.
    Type: Grant
    Filed: June 5, 1980
    Date of Patent: July 20, 1982
    Inventor: Thomas M. Camilleri
  • Positive cycle mechanism for bowling pinsetter
    Patent number: 4326712
    Abstract: A pinsetter cycling device adapted to be actuated in response to the slightest movement of the pin cushion. The device is constituted by a pair of flexible spring-like conductive members attached to and extending rearwardly of the pit cushion and a conductive surface adapted to be bridged to the flexible members upon the slightest movement of the cushion. The flexible members are electrically connected to the pinsetter cycle means to actuate same on being moved into contact with the conductive surface.
    Type: Grant
    Filed: June 5, 1980
    Date of Patent: April 27, 1982
    Inventor: Thomas M. Camilleri
  • Respot cell pads for automatic bowling machine
    Patent number: 4198473
    Abstract: An improved respot cell pad for a pinspotter automatic bowling machine is formed of high density flexible, resilient, compression resistent cellular material.
    Type: Grant
    Filed: January 9, 1978
    Date of Patent: April 15, 1980
    Inventor: Thomas M. Camilleri
  • Lifts for ball elevator
    Patent number: 4071240
    Abstract: A lift for a ball elevator wheel for an automatic pinsetting bowling machine is formed of a substantially rectangular strip of flexible elastomeric material with a first bevel in the direction of rotation of the elevator wheel and a second bevel facing the open front of the elevator wheel. At least one and preferably two strips are provided. The strips cover only a minor portion of the inner circumference of the elevator wheel.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: January 31, 1978
    Inventor: Thomas M. Camilleri
  • Floor tile
    Patent number: D259893
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: July 14, 1981
    Inventor: Bruno Fidel
  • Weather vane
    Patent number: D275085
    Type: Grant
    Filed: April 19, 1982
    Date of Patent: August 14, 1984
    Inventor: Richard A. Mauro