Patents Represented by Attorney D. K. Shelton

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  • Immunoassay of terminal deoxynucleotidyl transferase
    Patent number: 4515890
    Abstract: This disclosure relates to a method for the quantitative in vitro determination of terminal deoxynucleotidyl transferase in human blood extracts, bone marrow extracts and lymphocyte extracts and wherein the terminal deoxynucleotidyl transferase is extracted with an extractant containing a nonionic surfactant, an anticoagulant and a reducing agent.
    Type: Grant
    Filed: November 8, 1982
    Date of Patent: May 7, 1985
    Assignee: Abbott Laboratories
    Inventors: George L. Manderino, Adoracion F. Suarez
  • Hapten-inhibitor immunoassay
    Patent number: 4430263
    Abstract: A specific binding assay method employing, as a labeling substance, a reversible trypsin inhibitor for the detection of a hapten. Competition between the hapten to be determined and hapten trysin inhibitor conjugate for antibody to the hapten, in the presence of enzyme, followed by addition of enzyme substrate provides an effective method for hapten analysis. The preferred trypsin inhibitor is a protein having a molecular weight range of 2,000-75,000. The preferred ratio of the hapten to the inhibitor in the conjugate is between 1:1 and 3:1.
    Type: Grant
    Filed: January 21, 1980
    Date of Patent: February 7, 1984
    Assignee: Abbott Laboratories
    Inventors: Steven C. March, John W. Safford, Jr., Susan E. Magic