Abstract: A medical syringe needle sheath holding device (10) for use in uncapping and recapping a needle sheath over a needle of a medical syringe, which is portable and easy to use. The holding device (10) includes a holder body (16) having a sheath receiving passage (21) formed therethrough. A plunger (35) projects from one end of the holder body (16) and includes a sheath receiving aperture (39) formed therein. As the plunger is depressed, the sheath receiving aperture (39) of the plunger (35) is aligned with the sheath receiving passage (21) of the holder body. (16) to enable the needle sheath to be inserted therein. As the plunger (35) is released, it is urged rearwardly along the holder body (16) by a spring (42) so that the needle sheath is engaged and held between the plunger (35) and the holder body (16).