Abstract: Preparation of an optically active alkamine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO-- where R is hydrogen or an alkali metal)-1,2,5-thiadiazole to prepare S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents. Novel 3-morpholino-4-chloro(or RO--)-1,2,5-thiadiazoles and their preparation also are described.
Type:
Grant
Filed:
November 19, 1973
Date of Patent:
June 8, 1976
Assignee:
Merck & Co., Inc.
Inventors:
Leonard M. Weinstock, Roger J. Tull, Dennis M. Mulvey