Patents Represented by Attorney Daniel A. Pearson

Find this attorney in the Justia Lawyer Directory

  • Compositions useful as inhibitors of rock and other protein kinases
    Patent number: 7531556
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: April 27, 2005
    Date of Patent: May 12, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventor: Jeremy Green
  • Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
    Patent number: 7528138
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: May 5, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Ronald Knegtel, Juan-Miguel Jimenez, Jean-Damien Charrier, Dean Stamos, Pan Li, Jon Come, Alex Aronov
  • Azaindoles useful as inhibitors of rock and other protein kinases
    Patent number: 7514448
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: April 4, 2005
    Date of Patent: April 7, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Andrew Miller, Juan-Miguel Jimenez, Craig Marhefka, Jingrong Cao, John Court, Upul Bandarage, Huai Gao, Suganthini Nanthakumar
  • Selective inhibitors of ERK protein kinase and uses thereof
    Patent number: 7501415
    Abstract: Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: March 10, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alexander Aronov, Michael Hale, Francois Maltais, Gabriel Martinez-Botella, Judith Straub, Qing Tang
  • Pyridine inhibitors of ERK2 and uses thereof
    Patent number: 7462612
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: December 9, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Hale, Gabriel Martinez-Botella, Qing Tang
  • Compositions useful as protein kinase inhibitors
    Patent number: 7456190
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: November 25, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Francois Maltais, Alex Aronov, Michael R. Hale, Young-Choon Moon
  • Compositions useful as inhibitors of protein kinases
    Patent number: 7446199
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: November 4, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alex Aronov, David J. Lauffer, Pan Li, Ronald C. Tomlinson
  • Heteroaryl compounds useful as inhibitors or protein kinases
    Patent number: 7407962
    Abstract: The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: August 5, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alex Aronov, Michael R. Hale, Francois Maltais, Qing Tang
  • Prodrugs of an ERK protein kinase inhibitor
    Patent number: 7358258
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: April 15, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Robin Hale, Francois Maltais, Gabriel Martinez-Botella, Judith Straub, Qing Tang
  • Isoxazole compositions useful as inhibitors of ERK
    Patent number: 7354919
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: where A, B, R1, R2, T and Ht are described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein, kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: April 8, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael R. Hale, James W. Janetka, Francois Maltais, Jingrong Cao
  • Pyrrole inhibitors of ERK protein kinase, synthesis thereof and intermediates thereto
    Patent number: 7354939
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: April 8, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gabriel Martinez-Botella, Michael Hale, Francois Maltais, Judith Straub, Qing Tang
  • Heterocyclic inhibitors of ERK2 and uses thereof
    Patent number: 7345054
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein A1, A2, TmR1, X, R2, R3, R9, R12, and R13 are as described in the specification. The compounds are especially useful as inhibitors of ERK2, Aurora2, GSK3, CDK2, AKT3, and ROCK protein kinases and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, neurodegenerative disorders, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: March 18, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Robin Hale, Francois Maltais, Qing Tang, Judith Straub, Alexander Aronov
  • Pyrrole compounds useful as kinase inhibitors
    Patent number: 7314885
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for making the compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: January 1, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alex Aronov, Upul K. Bandarage, David J. Lauffer, Pan Li, Ronald C. Tomlinson
  • Protein kinase inhibitors and uses thereof
    Patent number: 7304071
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formulae I and V: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, T, m, n, p, Q, Q?, R1, R2, Rx, R3, and R6 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: December 4, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: John Cochran, Jeremy Green, Michael R. Hale, Brian Ledford, Francois Maltais, Suganthini Nanthakumar
  • Heterocyclic inhibitors of ERK2 and uses thereof
    Patent number: 7304061
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein A1, A2, TmR1, X, R2, R3, R9, R12, and R13 are as described in the specification. The compounds are especially useful as inhibitors of ERK2, Aurora2, GSK3, CDK2, AKT3, and ROCK protein kinases and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, neurodegenerative disorders, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: December 4, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Robin Hale, Francois Maltais, Qing Tang, Judith Straub, Alexander Aronov
  • Pyrazole-derived kinase inhibitors and uses thereof
    Patent number: 7279476
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where B, R1, n, R3, Q, and R4 are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: October 9, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Oing Tang, Francois Maltais, James Walter Janetka, Michael Robin Hale
  • Diaminotriazoles useful as inhibitors of protein kinases
    Patent number: 7279469
    Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: October 9, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Albert C. Pierce, Michael Amost, Robert J. Davies, Cornelia J. Forster, Vincent Galullo, Ronald Grey, Jr., Mark Ledeboer, Shi-Kai Tian, Jinwang Xu, Hayley Binch, Brian Ledford, David Messersmith, Suganthi Nanthakumar, Andrew Jayaraj, Greg Henkel, Francesco G. Salituro, Jian Wang
  • Thiazoles useful as inhibitors of protein kinases
    Patent number: 7276502
    Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: October 2, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Guy Brenchley, Luc J. Farmer, Edmund M. Harrington, Ronald Knegtel, Michael O'Donnell, Francesco G. Salituro, John R. Studley, Jian Wang
  • Compositions useful as inhibitors of protein kinases
    Patent number: 7268136
    Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of PIM-1, CDK-2, GSK-3, and SRC mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: September 11, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Ronald Grey, Jr., Albert C. Pierce
  • Heterocyclic inhibitors of ERK2 and uses thereof
    Patent number: 7253187
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: August 7, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jingrong Cao, Jeremy Green, Michael Hale, Francois Maltais, Judy Straub, Qing Tang, Alex Aronov