Patents Represented by Attorney Daniel B. Moran

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  • 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers
    Patent number: 6465523
    Abstract: 4-Substituted-3-substituted-amino-cyclobutyl-3-ene-1,2-diones having the Formula (I): wherein R1, R2, R3, R4, R5, A and W are as defined in the specification which compounds relaxes smooth muscles.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: October 15, 2002
    Assignee: American Home Products
    Inventors: John A. Butera, Joseph R. Lennox, Douglas J. Jenkins
  • 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers
    Patent number: 6462059
    Abstract: 4-Substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones having the Formula (I): wherein R1, R2, R3, R4, R5, A and W are as defined in the specification which compounds relaxes smooth muscles.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: October 8, 2002
    Assignee: American Home Products
    Inventors: John A. Butera, Joseph R. Lennox, Douglas J. Jenkins
  • Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives
    Patent number: 6403581
    Abstract: The invention is a method of treating, inhibiting or controlling a ras-associated disease by inhibiting farnesyl-protein transferase(FPTase) enzyme, treating ras oncogene-dependent tumors, which include cancers of pancreas, breast, lung, colon, epidermis, prostate, bladder, thyroid, myelodysplastic tumors and myeloid leukemia; controlling metastasis, suppressing angiogenesis, inducing apoptosis, and in treating Ras-associated proliferative diseases other than cancer, such as restenosis, neuro-fibromatosis, endometriosis, and psoriasis, in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, Q, a, and b are defined in the specification.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: June 11, 2002
    Assignee: American Cyanamid Company
    Inventors: Semiramis Ayral-Kaloustian, Douglas Bruce Kitchen, Andrei Shavnya
  • Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
    Patent number: 6391902
    Abstract: Compounds of the Formulae (I) and (II): wherein R1, R2, R3, X, Y and Z are as defined in the specification which compounds are useful in the treatment of disorders associated with smooth muscle contraction via potassium channel modulation.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: May 21, 2002
    Assignee: American Home Products Corporation
    Inventors: Schuyler A. Antane, John A. Butera, Joseph R. Lennox
  • 2,4,6-trisbstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof
    Patent number: 6384060
    Abstract: The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: May 7, 2002
    Assignee: American Home Products Corporation
    Inventors: Chingfan Chiu, Zhilian Tang, John W. Ellingboe
  • 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis
    Patent number: 6384057
    Abstract: The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: May 7, 2002
    Assignee: American Home Products Corporation
    Inventors: Chingfan Chiu, Zhilian Tang, John W. Ellingboe
  • 2,4,6-trisubstituted pryridines with estrogenic activity and methods for the solid phase synthesis thereof
    Patent number: 6384058
    Abstract: The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: May 7, 2002
    Assignee: American Home Products Corporation
    Inventors: Chingfan Chiu, Zhilian Tang, John W. Ellingboe
  • 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers
    Patent number: 6376555
    Abstract: 4-Substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones having the Formula (I): wherein R1, R2, R3, R4, R5, A and W are as defined in the specification which compounds relaxes smooth muscles.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: April 23, 2002
    Assignee: American Home Products Corporation
    Inventors: John A. Butera, Joseph R. Lennox, Douglas J. Jenkins
  • Reversal of multidrug resistance in human colon carcinoma cells
    Patent number: 6372775
    Abstract: The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: April 16, 2002
    Assignee: American Cyanamid Company
    Inventors: Sridhar Krishna Rabindran, Haiyin He, Lee Martin Greenberger
  • Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
    Patent number: 6288099
    Abstract: Compounds of the Formulae (I) and (II): wherein R1, R2, R3, X, Y and Z are as defined in the specification which compounds are useful in the treatment of disorders associated with smooth muscle contraction via potassium channel modulation.
    Type: Grant
    Filed: December 3, 1999
    Date of Patent: September 11, 2001
    Assignee: American Home Products Corporation
    Inventors: Schuyler A. Antane, John A. Butera, Joseph R. Lennox
  • Substituted benzo[1,4]dioxines as antiobesity agents
    Patent number: 6083975
    Abstract: This invention relates to novel substituted 1,4-benzodioxine compounds having antidiabetic, antihyperglycemic, and antiobesity properties represented by the formula ##STR1## wherein R.sup.1 and R.sup.6 are independently hydrogen, C.sub.1 to C.sub.6 alkyl, trifluoromethyl, cyano, C.sub.1 to C.sub.6 alkoxy, or halogen;R.sup.2 is hydrogen or C.sub.1 to C.sub.6 trialkylsilyl; R.sup.3 is hydrogen or C.sub.1 to C.sub.6 alkoxycarbonyl;or R.sup.2 and R.sup.3 are joined to form the oxazolidinone ring ##STR2## R.sup.4 and R.sup.5 are independently hydrogen or C.sub.1 to C.sub.6 alkyl;R.sup.7 and R.sup.8 are independently OR.sup.9 or NR.sup.10 R.sup.11 ;R.sup.9 is hydrogen, C.sub.1 to C.sub.12 alkyl, C.sub.1 to C.sub.12 cycloalkyl, C.sub.1 to C.sub.12 silylalkyl, phenyl, naphthyl, phenyl C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy C.sub.1 to C.sub.6 alkyl, pyridyl, thiophenyl, furanyl, imidazolyl, oxazolyl, --CHR.sup.12 COOR.sup.13, --CHR.sup.12 C(O)R.sup.13, --CHR.sup.12 CONR.sup.10 R.sup.11, --CHR.sup.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: July 4, 2000
    Assignee: American Home Products
    Inventor: Aranapakam M. Venkatesan
  • Substituted dibenzothiophenes having antiangiogenic activity
    Patent number: 6022307
    Abstract: The invention provides novel substituted dibenzothiophenes of Formulae (I), (II), (III) and (IV) which have antiangiogenic activity and further provides a method using substituted dibenzothiophenes of Formula (V) as antiangiogenic agents.
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: February 8, 2000
    Assignee: American Cyanamid Company
    Inventors: Mark E. Salvati, Nancy H. Eudy, William A. Hallett, Dennis William Powell
  • Substituted benzo[1,4]dioxines as antiobesity agents
    Patent number: 6020361
    Abstract: This invention relates to novel substituted 1,4-benzodioxine compounds having antidiabetic, andihyperglycemic, and antiobesity properties represented by the formula ##STR1## wherein R.sup.1 and R.sup.6 are independently hydrogen, C.sub.1 to C.sub.6 alkyl, trifluoromethyl, cyano, C.sub.1 to C.sub.6 alkoxy, or halogen;R.sup.2 is hydrogen or C.sub.1 to C.sub.6 trialkylsilyl; R.sup.3 is hydrogen or C.sub.1 to C.sub.6 alkoxycarbonyl;or R.sup.2 and R.sup.3 are joined to form the oxazolidinone ring ##STR2## R.sup.4 and R.sup.5 are independently hydrogen or C.sub.1 to C.sub.6 alkyl; R.sup.7 and R.sup.8 are independently hydrogen OR.sup.9 or NR.sup.10 R.sup.11 ;R.sup.9 is hydrogen, C.sub.1 to C.sub.12 alkyl, C.sub.1 to C.sub.12 cycloalkyl, C.sub.1 to C.sub.12 silylalkyl, phenyl, naphthyl, phenyl C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy C.sub.1 to C.sub.6 alkyl, pyridyl, thiophenyl, furanyl, imidazolyl, oxazolyl, --CHR.sup.12 COOR.sup.13, --CHR.sup.12 C(O)R.sup.13, --CHR.sup.12 CONR.sup.10 R.sup.11, --CHR.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: February 1, 2000
    Assignee: America Home Products Corp.
    Inventor: Aranapakam M. Venkatesan
  • Substituted Benzo[1,4]dioxines as antiobesity agents
    Patent number: 5965607
    Abstract: This invention relates to novel substituted 1,4-benzodioxine compounds having antidiabetic, antihyperglycemic, and antiobesity properties represented by the formula ##STR1## wherein R.sup.1 and R.sup.6 are independently hydrogen, C.sub.1 to C.sub.6 alkyl, trifluoromethyl, cyano, C.sub.1 to C.sub.6 alkoxy, or halogen;R.sup.2 is hydrogen or C.sub.1 to C.sub.6 trialkylsilyl; R.sup.3 is hydrogen or C.sub.1 to C.sub.6 alkoxycarbonyl;or R.sub.2 and R.sup.3 are joined to form the oxazolidinone ring ##STR2## R.sup.4 and R.sup.5 are independently hydrogen or C.sub.1 to C.sub.6 alkyl;R.sup.7 and R.sup.8 are independently OR.sup.9 or NR.sup.10 R.sup.11 ;R.sup.9 is hydrogen, C.sub.1 to C.sub.12 alkyl, C.sub.1 to C.sub.12 cycloalkyl, C.sub.1 to C.sub.12 silylalkyl, phenyl, naphthyl phenyl C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy C.sub.1 to C.sub.6 alkyl, pyridyl, thiophenyl, furanyl, imidazolyl, oxazolyl, --CHR.sup.12 COOR.sup.13 --CHR.sup.12 C(O)R.sup.13, --CHR.sup.12 CONR.sup.10 R.sup.11, --CHR.sup.12 OCOOR.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: October 12, 1999
    Assignee: American Home Products Corporation
    Inventor: Aranapakam M. Venkatesan