Patents Represented by Attorney Daniel C. Chambers

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  • Enhanced indole biosynthesis
    Patent number: 5494816
    Abstract: DNA molecules encoding a modified tryptophan synthase beta subunit are disclosed. When expressed in a recombinant host microorganism, these polypeptide analogs enable significant levels of intracellular indole production and accumulation. In the presence of an aromatic dioxygenase enzyme, the indole so produced can be converted to indoxyl, which upon exposure to air oxidizes to indigo.
    Type: Grant
    Filed: June 21, 1994
    Date of Patent: February 27, 1996
    Assignee: Amgen Inc.
    Inventor: Douglas C. Murdock