Patents Represented by Attorney, Agent or Law Firm Daniel D. Ryan
  • Peristaltic pump tube cassette with angle pump tube connectors
    Patent number: 5427509
    Abstract: A peristaltic pump tube holder has a body having first and second pump tube connectors extending outside of it. The pump tube connectors extend at an acute angle relative to a surface of the body to receive a flexible tubing loop and orient the tubing loop for engagement with an external peristaltic pump rotor.
    Type: Grant
    Filed: December 22, 1993
    Date of Patent: June 27, 1995
    Assignee: Baxter International Inc.
    Inventors: Arthur S. Chapman, T. Michael Dennehey, Richard I. Brown, Warren P. Williamson
  • Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate
    Patent number: 5427695
    Abstract: Systems and methods resuspend cellular-rich concentrates of blood by rocking the separation chamber to create variable agitation forces within the separation chamber. The systems and methods also add resuspension fluids to aid the resuspension.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: June 27, 1995
    Assignee: Baxter International Inc.
    Inventor: Richard I. Brown
  • Peritoneal dialysis methods that emulate gravity flow
    Patent number: 5421823
    Abstract: Peritoneal dialysis systems and methods apply fluid pressure to move liquid. The systems and methods can emulate either a fixed head height condition or different head height conditions, independent of the actual head height differential between the patient's peritoneal cavity and the external liquid source or destination. The systems and methods can also switch between low-relative pressure flow mode when considerations of patient comfort and safety predominate and a high-relative pressure flow mode when considerations of processing speed predominate.
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: June 6, 1995
    Assignee: Deka Products Limited Partnership
    Inventors: Dean Kamen, Geoffrey P. Spencer
  • Blood storage container and material
    Patent number: 5382526
    Abstract: A blood bag comprises a plastic polyvinyl chloride formulation in which the polyvinyl chloride formulation contains from 5 to 30 percent by weight of a first plasticizer material which is essentially nonextractable by blood plasma stored in the bag up to 35 days at about 4.degree. C.; and from 10 to 25 percent by weight of a second plasticizer which is significantly extracted by blood plasma stored in the bag up to 35 days at about 4.degree. C.
    Type: Grant
    Filed: March 17, 1989
    Date of Patent: January 17, 1995
    Assignee: Baxter International Inc.
    Inventors: Henry M. Gajewski, Barry H. Vernick, Paul E. Measells, Jan W. Garber
  • Enhanced yield platelet collection systems and methods
    Patent number: 5370802
    Abstract: Systems and methods for separating a suspension of plasma and platelets from whole blood rotate a chamber about an axis to create within the chamber a low-G zone radially close to the axis and a high-G zone spaced radially further from the axis than the low-G zone. The systems and methods introduce whole blood into an inlet region of the chamber to initiate separation of red blood cells toward the high-G zone of the inlet region. This creates a strong flow of plasma that moves radially toward the low-G zone of the inlet region and elutes platelets into suspension with it. The systems and methods direct the radial flow of plasma and eluted platelets within the inlet region to a port in the inlet region for transport out of the chamber. The systems and methods also drag the interface into this radial plasma flow, eluting even the largest of platelets into suspension for collection.
    Type: Grant
    Filed: October 22, 1992
    Date of Patent: December 6, 1994
    Assignee: Baxter International Inc.
    Inventor: Richard I. Brown
  • Centrifugal processing system with direct access drawer
    Patent number: 5362291
    Abstract: A drawer-mounted centrifuge provides easy access for loading and unloading disposable processing elements. The centrifuge also includes an umbilicus holder that moves between an operating position and an out-of-the-way position as the drawer opens and closes.
    Type: Grant
    Filed: February 9, 1994
    Date of Patent: November 8, 1994
    Assignee: Baxter International Inc.
    Inventor: Warren P. Williamson, IV
  • Centrifuge with separable bowl and spool elements providing access to the separation chamber
    Patent number: 5360542
    Abstract: A centrifuge provides simplify access to the processing chamber. In one arrangement, the processing chamber separates into a bowl and spool element to receive a disposable processing bag. In another arrangement, the processing chamber pivots between an operating position and an access position to provide improved access. The centrifuge also employs readily accessible holders for releasably retaining tubing that, in use, conveys fluid to and from the chamber. Though greatly accessible, the centrifuge operates without the need of complicated rotating seals and expensive disposable components.
    Type: Grant
    Filed: November 2, 1993
    Date of Patent: November 1, 1994
    Assignee: Baxter International Inc.
    Inventors: Warren P. Williamson, IV, Richard I. Brown
  • Peritoneal dialysis systems employing a liquid distribution and pumping cassette that emulates gravity flow
    Patent number: 5350357
    Abstract: Peritoneal dialysis systems apply fluid pressure to move liquid. The systems can emulate either a fixed head height condition or different head height conditions, independent of the actual head height differential between the patient's peritoneal cavity and the external liquid source or destination. The systems can also switch between low-relative pressure flow mode when considerations of patient comfort and safety predominate and a high-relative pressure flow mode when considerations of processing speed predominate.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: September 27, 1994
    Assignee: Deka Products Limited Partnership
    Inventors: Dean Kamen, Geoffrey P. Spencer, Douglas E. Vincent
  • Closed porous chambers for implanting tissue in a host
    Patent number: 5344454
    Abstract: Improved Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish an improved chamber for holding the implanted cells. The chambers include first and second wall elements and an intermediate sealing element. The first and second wall elements overlie an open area in the sealing member to form a chamber for holding cells for implantation. A sealed region is created between the wall elements and the sealing element body to close the chamber. In one arrangement, the sealed region is created by means of a sonic weld made while the implanted cells are present in the chamber. In another arrangement, the sealed region is created by means of applying an external force to compress the peripheral edges of the wall elements and the sealing element together while the implanted cells are present in the chamber.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: September 6, 1994
    Assignee: Baxter International Inc.
    Inventors: Robert A Clarke, Robin G. Pauley, Ronald S. Hill, James H. Brauker, Shmuel Sternberg, Daniel R. Boggs
  • User interface for automated peritoneal dialysis systems
    Patent number: 5324422
    Abstract: Systems for performing peritoneal dialysis allow the user to chose from an array of peritoneal dialysis modalities and adjust one or more individual therapy parameters within a selected modality. Still, the systems assure that the selected modality and therapy parameters satisfy preselected composite therapy criteria.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: June 28, 1994
    Assignee: Baxter International Inc.
    Inventors: Lisa Colleran, Rie Inoue, Mark Senninger
  • Time based interface detection systems for blood processing apparatus
    Patent number: 5316667
    Abstract: A system for monitoring the interface region between cellular constituents and plasma in a blood separation chamber employs a sensor mechanism for emitting upon the interface region energy that is absorbed by the cellular constituents. The sensor mechanism also detects the intensity of the energy that is not absorbed by the interface region to generate an unabsorbed intensity output signal. The system moves the interface region relative to the sensor mechanism during a prescribed time period. A first circuit measures variations in the unabsorbed intensity output signal over the prescribed time period and generates a time based output. A second circuit can derive the physical size of the interface region based upon the time based output.
    Type: Grant
    Filed: August 19, 1993
    Date of Patent: May 31, 1994
    Assignee: Baxter International Inc.
    Inventors: Richard L. Brown, John T. Foley
  • Blood processing systems with improved data transfer between stationary and rotating elements
    Patent number: 5316666
    Abstract: Systems transmit a control signal between a rotating element and a stationary element of a blood separation centrifuge. The systems employ a sensor mechanism carried by one of the rotating and stationary elements. The sensor mechanism senses an operating condition that is subject to change. The sensor mechanism generates a first output signal that varies according to changes in the sensed operating condition. A first data transfer component on the one element that carries the sensor mechanism emits energy to the other element without mechanical contact with the other element. The first data transfer mechanism modulates the emitted energy according to variations occurring in the intensity of the first output signal. A second data transfer component on the other element receives the modulated energy emitted by the first data transfer component.
    Type: Grant
    Filed: August 19, 1993
    Date of Patent: May 31, 1994
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, John T. Foley
  • Tissue inplant systems and methods for sustaining viable high cell densities within a host
    Patent number: 5314471
    Abstract: Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografts, and isografts. The assemblies and methodologies establish a boundary between the host and the implanted cells. The boundary has a pore size, an ultimate strength, and a metabolic transit value that assures the survival of the cells during the critical ischemic period and afterward. The boundary allows the fabrication and clinical use of implant assemblies and methodologies that can carry enough cells to be of therapeutic value to the host, yet occupy a relatively small, compact area within the host.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: May 24, 1994
    Assignee: Baxter International Inc.
    Inventors: James H. Brauker, Ronald S. Hill, Laura A. Martinson, Daniel R. Boggs, Robert C. Johnson
  • Systems and methods for eradicating contaminants using photoactive materials in fluids like blood
    Patent number: 5300019
    Abstract: A system and method for treating a fluid carrying a biological contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method expose the fluid, as it transits the gap, to a source of radiation that activates the photoactive material bound to the contaminant. The system and method also mix the fluid as it flows within the gap.
    Type: Grant
    Filed: December 17, 1992
    Date of Patent: April 5, 1994
    Assignee: Baxter International Inc.
    Inventors: Daniel F. Bischof, Ludwig Wolf, Jr., John T. Foley, William R. Bratten
  • Systems for eradicating contaminants using photoactive materials in fluids like blood
    Patent number: 5290221
    Abstract: Systems for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a relatively narrow, arcuately shaped flow path. These systems envelop the path with a radiation chamber that directs radiation from one or more sources into the fluid.
    Type: Grant
    Filed: December 17, 1992
    Date of Patent: March 1, 1994
    Assignee: Baxter International Inc.
    Inventors: Ludwig Wolf, Jr., John T. Foley, William R. Bratten
  • Systems and methods for removing undesired matter from blood cells
    Patent number: 5269946
    Abstract: Systems and methods of collecting blood cells use a first container connected to at least three transfer containers. A filtration system is provided with one transfer container, which ultimately serves as the storage container for red blood cells free of white blood cells. The two other transfer containers are connected to each other, one of which is empty and one of which contains and additive solution for storage of red blood cells. The empty transfer container is used for storage of platelet concentrate, while the container that originally contained the additive solution is ultimately used to store the platelet-poor plasma component. A portion of the additive solution may be separately passed through the filtration system after filtration of the red cells to flush additional red blood cells from the filtration device.
    Type: Grant
    Filed: May 22, 1991
    Date of Patent: December 14, 1993
    Assignee: Baxter Healthcare Corporation
    Inventors: Richard Goldhaber, Daniel F. Bischof
  • Systems and methods for processing cellular rich suspensions
    Patent number: 5234608
    Abstract: A processing system separates a cellular rich suspension into a cellular first constituent and cellular-free second constituent. The system includes a separation zone that receives the cellular rich suspension and discharges the first and second constituents. The system coordinates the flow of cellular rich suspension into the separation zone with the flow of the cellular-free second constituent from the separation zone to get a desired nominal separation efficiency. The system also recirculates the cellular first constituent back into the zone. By continuously recirculating the cellular first constituent back into the separation zone, the system is can get and maintain a desired volume of the first constituent, despite the volume of cellular rich suspension that is processed.
    Type: Grant
    Filed: December 11, 1990
    Date of Patent: August 10, 1993
    Assignee: Baxter International Inc.
    Inventor: Daniel H. Duff
  • Mobile, self-contained blood collection system and method
    Patent number: 5232437
    Abstract: Methods and systems for collection of blood components, such as plasma, from donors are provided. One method includes the steps of collecting a unit of whole blood from a donor; forcing the collected blood unit through a plasma separator; accumulating the plasma in a container; and returning concentrated cells to the donor. One system includes a disposable blood collection set and a reusable fixture into which the collection set can be mounted. The fixture is operated by a self-contained energy source, requiring no exterior electrical connection or other external source of energy.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: August 3, 1993
    Assignee: Baxter International Inc.
    Inventors: Michael J. Lysaght, Daniel R. Boggs, Philip L. Ritger, Robert R. Stromberg, Leonard I. Friedman
  • Single needle continuous hemapheresis apparatus and methods
    Patent number: 5188588
    Abstract: Blood separation is accomplished by alternately extracting blood from and reinfusing blood into a donor by way of a single needle while simultaneously and continuously separating the extracted blood into constituents. A harness set applicable to a hemapheresis instrument includes a dual-compartment reservoir. A first compartment stores blood during extraction for supply to the separator during reinfusion. The second compartment stores packed cells during collection for return to the donor during reinfusion. The collection and reinfusion cycles are alternated rapidly to preclude clotting in the un-anticoagulated portion of the harness tubing between the venepuncture needle and the Y-connection with the anticoagulant line.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: February 23, 1993
    Assignee: Baxter Internatonal Inc.
    Inventors: Donald W. Schoendorfer, Paul R. Prince
  • Peritoneal dialysis cycler
    Patent number: D351470
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: October 11, 1994
    Assignee: Baxter International Inc.
    Inventors: Craig S. Scherer, James D. Brewer, David C. Brown, Christopher S. LaBak, Russell L. Robertson