Patents Represented by Attorney Daniel T. Szura

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  • Process for the preparation of methyl 2,6-dideoxy-.alpha.-D-arabino-hexopyranoside
    Patent number: 4415731
    Abstract: Disclosed is a process for preparing methyl 2,6-dideoxy-.alpha.-D-arabino-hexopyranoside from methyl 2-deoxy-.alpha.-D-glucopyranoside.
    Type: Grant
    Filed: March 30, 1981
    Date of Patent: November 15, 1983
    Assignee: Merck & Co., Inc.
    Inventor: Philippe L. Durette
  • Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-.beta.,2-dioxo-4-azetidinebutanoic acid
    Patent number: 4414155
    Abstract: Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: ##STR1## wherein R.sup.3 is a readily removable carboxyl protecting group.
    Type: Grant
    Filed: March 29, 1982
    Date of Patent: November 8, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Thomas M. H. Liu, David G. Melillo, Kenneth M. Ryan, Ichiro Shinkai, Meyer Sletzinger
  • Preparation of epihalohydrin enantiomers
    Patent number: 4408063
    Abstract: Processes for preparing (S) or (R) epihalohydrin and an (S) substituted glycerol intermediate are disclosed.
    Type: Grant
    Filed: April 19, 1982
    Date of Patent: October 4, 1983
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Imidazodiazines
    Patent number: 4408047
    Abstract: Novel imidazopyridines, -pyrazines, -pyrimidines and -pyridazines having a 3-amino-2-OR-propoxy substituent, are disclosed. The compounds have .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: November 19, 1981
    Date of Patent: October 4, 1983
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, William C. Lumma, Jr.
  • Dipeptidase inhibitors
    Patent number: 4406902
    Abstract: Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are Z-2-(2,2-dimethylcyclo-propanecarboxamido)-.omega.-pyridylthio-2-alkenoic acids (and related arylthio and heterocyclylthio analogs).
    Type: Grant
    Filed: July 23, 1981
    Date of Patent: September 27, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Wallace T. Ashton, Louis Barash, Jeannette E. Brown, Donald W. Graham
  • Methyldopa composition
    Patent number: 4404193
    Abstract: An aqueous suspension containing methyldopa and sucrose is disclosed. This composition is an oral dosage form for treating hypertension that is bioavailable.
    Type: Grant
    Filed: October 9, 1981
    Date of Patent: September 13, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Dempski, Joseph L. O'Neill
  • Novel .alpha.-amino acids
    Patent number: 4401676
    Abstract: Novel .alpha.-ethynyl- and .alpha.-vinyl 3,4-disubstituted phenylalanines are disclosed. The compounds have pharmaceutical activity.
    Type: Grant
    Filed: June 1, 1977
    Date of Patent: August 30, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, David Taub
  • 3-[1-Hydroxyethyl]-4-carboxymethyl-azetidin-2-one
    Patent number: 4400323
    Abstract: In a process for the total synthesis of thienamycin from L-aspartic acid via intermediate III: ##STR1## there is disclosed a process for preparing III via ##STR2## wherein R is a protecting group.
    Type: Grant
    Filed: January 21, 1981
    Date of Patent: August 23, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Ronald W. Ratcliffe, Thomas N. Salzmann
  • Certain nicotinic acid esters and corresponding nicotinonitriles
    Patent number: 4393212
    Abstract: Novel substituted (3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, their pharmaceutically acceptable salts, certain intermediates and their preparation are disclosed. These pyridines have pharmaceutically useful properties such as .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: May 13, 1981
    Date of Patent: July 12, 1983
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Process for preparing methylvanillyl ketone from isoeugenol
    Patent number: 4393242
    Abstract: Methylvanillyl ketone is prepared from a "through process" involving oxidation of isoeugenol followed by subsequent acidic hydrolysis.
    Type: Grant
    Filed: July 6, 1981
    Date of Patent: July 12, 1983
    Assignee: Merck & Co., Inc.
    Inventor: Meyer Sletzinger
  • Intermediates for the resolution of some interphenylene-9-thia-11-oxo-12-azaprostanoic acids
    Patent number: 4390703
    Abstract: Some derivatives of interphenylene-9-thia-11-oxo-12-azaprostanoic acid which are active renal vasodilator agents are resolved via diastereomeric camphanyl or camphorcarbonyl esters. Upon hydrolysis, the separated diastereoisomers yield optically pure enantiomers.
    Type: Grant
    Filed: June 22, 1981
    Date of Patent: June 28, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Robert M. Di Pardo
  • Method of treating hypertension
    Patent number: 4389415
    Abstract: A pharmaceutical composition containing .alpha.-methyl-p-tyrosine and carbidopa and method of treating hypertension are described.
    Type: Grant
    Filed: July 20, 1981
    Date of Patent: June 21, 1983
    Assignee: Merck & Co., Inc.
    Inventor: Alexander Scriabine
  • Synthesis of thienamycin from D-glucose
    Patent number: 4384998
    Abstract: Disclosed is a chiral, total synthesis of thienamycin from D-glucose which proceeds via intermediates I, II and III to known aldehyde IV which is known to be useful in the total synthesis of thienamycin (V): ##STR1## wherein: R is lower alkyl having 1-6 carbon atoms or bi-valent alkyl having 2-6 carbon atoms which joins the two sulfur atoms; R.sup.1 is lower alkyl or aralkyl, such as benzyl and the like; and R.sup.2 is hydrogen or a removable protecting group, such as triorganosilyl wherein the organo groups are independently selected from lower alkyl, phenyl and phenylloweralkyl.
    Type: Grant
    Filed: March 30, 1981
    Date of Patent: May 24, 1983
    Assignee: Merck & Co., Inc.
    Inventor: Philippe L. Durette
  • Anti-inflammatory composition
    Patent number: 4379792
    Abstract: A pharmaceutical composition containing an interphenylene 9-thia-11-oxo-12-aza prostanoic acid type renal vasodilator and a non-steroidal anti-inflammatory agent and its use are disclosed.
    Type: Grant
    Filed: December 21, 1981
    Date of Patent: April 12, 1983
    Assignee: Merck & Co., Inc.
    Inventor: Edward H. Blaine
  • 2-Substituted propoxy-3-cyano-5-hydroxypyridines and use as antihypertensives
    Patent number: 4374140
    Abstract: The present application discloses certain 2-substituted propoxy-3-cyano-5-hydroxypyridines. The compounds have pharmaceutical activity e.g. as antihypertensives.
    Type: Grant
    Filed: February 10, 1981
    Date of Patent: February 15, 1983
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello, Stanley Vickers, Alfred Steuerwald
  • Glyceryl ester of 1-methyl-2-(3,4-dihydroxyphenyl)alanine
    Patent number: 4360533
    Abstract: Glyceryl esters of 1-methyl-2-(3,4-dihydroxyphenyl)alanine, pharmaceutical compositions and method of treatment are disclosed.
    Type: Grant
    Filed: December 14, 1981
    Date of Patent: November 23, 1982
    Assignee: Merck & Co., Inc.
    Inventor: Arthur A. Patchett
  • Aralkylamindethanol heterocyclic compounds
    Patent number: 4358455
    Abstract: Heterocyclic aminoethanols of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: November 9, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Benzoxazines
    Patent number: 4349673
    Abstract: Compounds of the formula Het--O--CH.sub.2 --CHOR--CH.sub.2 -NHaralkyl where Het is a 10 membered N-containing ring are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: September 14, 1982
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Corp.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Quinolinyl ethanolamines
    Patent number: 4348398
    Abstract: Heterocyclic ethanolamines of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: September 7, 1982
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Joseph G. Atkinson, Burton K. Wasson
  • Process for preparing amino acids and esters
    Patent number: 4347375
    Abstract: A process for preparing .alpha.-amino acids or ester thereof having an .alpha.-vinyl substituent and certain intermediates are disclosed.
    Type: Grant
    Filed: December 3, 1980
    Date of Patent: August 31, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, William J. Greenlee