Abstract: The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold proteins is BBI.
Type:
Grant
Filed:
November 8, 2004
Date of Patent:
April 28, 2009
Assignee:
Genencor International, Inc.
Inventors:
Anthony G. Day, David A. Estell, Christopher J. Murray, Scott D. Power
Abstract: A novel DNA is provided which encodes an enzyme having phytase activity isolated from Trichoderma. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA and the use of the expressed phytase protein in feed as a supplement.
Type:
Grant
Filed:
October 9, 2002
Date of Patent:
March 31, 2009
Assignee:
Genencor International, Inc.
Inventors:
Nigel Dunn-Coleman, Frits Goedegebuur, Michael Ward
Abstract: The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.
Type:
Grant
Filed:
December 3, 2007
Date of Patent:
March 3, 2009
Assignee:
Genencor International, Inc.
Inventors:
Toby M. Baldwin, Kathleen A. Clarkson, Nigel Dunn-Coleman, Suzanne E. Lantz
Abstract: The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for the glucoamylases, vectors and host cells incorporating the DNA sequences, enzyme compositions and methods of using the glucoamylases in various applications.
Type:
Grant
Filed:
August 28, 2006
Date of Patent:
February 24, 2009
Assignee:
Genencor International, Inc.
Inventors:
Nigel Dunn-Coleman, Paulien Neefe-Kruithof, Craig E. Pilgrim, Piet Van Solingen, Donald E. Ward
Abstract: Described herein are methods and compositions for the production and secretion of polypeptides. Included herein is the use of interrupting peptide transport activity for an increase in polypeptide production and/or secretion.