Patents Represented by Attorney, Agent or Law Firm Dann, Dorman, Herrell and Skillman
  • Methods for inhibiting angiogenesis
    Patent number: 7452884
    Abstract: Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for use in the methods include 5-(2-pyrazinyl)-4methyl-1,2-dithiol-3-thione (Oltipraz) and its metabolites.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: November 18, 2008
    Assignee: Fox Chase Cancer Center
    Inventors: Bruce A. Ruggeri, Margie L. Clapper
  • Method and apparatus for performing amplification of nucleic acid on supports
    Patent number: 6468751
    Abstract: This invention features methods and apparatus for performing nucleic acid hybridization and amplification processes on a support. Such methods and apparatus are useful for synthesizing nucleic acid and detecting target nucleic acid for diagnostics and therapeutics.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: October 22, 2002
    Assignees: Mosaic Technologies, Inc., Whitehead Institute for Biomedical Research
    Inventors: Christopher P. Adams, Stephen J. Kron
  • Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
    Patent number: 6211165
    Abstract: Compositions and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the simultaneous administration of specific A3/A1 receptor agonists, to patients suffering from ischemic damage or at risk for the same. In yet another embodiment of the invention, a binary conjugate which acts as an agonist for the A3 receptor and an antagonist at the A2a receptor, is administered to reduce or prevent ischemic damage to the heart.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: April 3, 2001
    Assignees: The Trustees of the University of Pennsylvania, The United States of America as represented by the Department of Health and Human Services
    Inventors: Bruce T. Liang, Kenneth A. Jacobson
  • Anti-inflammatory polypeptide antagonists of human I1-8
    Patent number: 5912232
    Abstract: Polypeptides derived from human interleukin-8 (IL-8) or other alpha chemokines which act as anti-inflammatory agents for the therapy of autoimmune disease, inflammatory conditions, and various chronic inflammatory diseases such as rheumatoid arthritis and psoriasis.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: June 15, 1999
    Assignee: Board of Regents of the University of Nebraska
    Inventor: James E. Talmadge
  • Circular knitting machines
    Patent number: 5187951
    Abstract: A cam actuator for selectively moving cam elements axially between distinct operative positions in a circular knitting machine, the actuator including a series of adjacent pistions arranged along the axial line of displacement, and stop means for limiting the axial stroke of each piston in the direction of extension. Each piston co-operates with adjacent pistons in the series such that displacement of a given piston in the extend direction causes the remaining pistons located between the cam element and the given piston to be displaced in the extend direction by the stroke length undergone by the given piston.
    Type: Grant
    Filed: July 9, 1991
    Date of Patent: February 23, 1993
    Assignee: Bentley Group Limited
    Inventors: Edward C. Stroud, John D. Griffith