Abstract: Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for use in the methods include 5-(2-pyrazinyl)-4methyl-1,2-dithiol-3-thione (Oltipraz) and its metabolites.

Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Abstract: DNA constructs containing translational control elements are provided. These 5? regulatory segments facilitate high level expression of transgenes introduced into the plastids of higher plants.

Abstract: A rechargeable flashlight and charging assembly are provided in which the charger has a receptacle for vertically receiving a flashlight therein. The charger further has a second receptacle for holding an auxiliary battery, and a latch for securely holding the auxiliary battery in the second receptacle. The flashlight is formed to removably contain a battery assembly. A pivotal cover member of the flashlight provides access to the battery compartment and has a pair of conductors situated therein for connection to charging contacts within the charging receptacle.

Abstract: This invention features methods and apparatus for performing nucleic acid hybridization and amplification processes on a support. Such methods and apparatus are useful for synthesizing nucleic acid and detecting target nucleic acid for diagnostics and therapeutics.

Abstract: Compositions and methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the simultaneous administration of specific A3/A1 receptor agonists, to patients suffering from ischemic damage or at risk for the same. In yet another embodiment of the invention, a binary conjugate which acts as an agonist for the A3 receptor and an antagonist at the A2a receptor, is administered to reduce or prevent ischemic damage to the heart.

Abstract: Polypeptides derived from human interleukin-8 (IL-8) or other alpha chemokines which act as anti-inflammatory agents for the therapy of autoimmune disease, inflammatory conditions, and various chronic inflammatory diseases such as rheumatoid arthritis and psoriasis.

Abstract: A cam actuator for selectively moving cam elements axially between distinct operative positions in a circular knitting machine, the actuator including a series of adjacent pistions arranged along the axial line of displacement, and stop means for limiting the axial stroke of each piston in the direction of extension. Each piston co-operates with adjacent pistons in the series such that displacement of a given piston in the extend direction causes the remaining pistons located between the cam element and the given piston to be displaced in the extend direction by the stroke length undergone by the given piston.