Abstract: The present invention provides Dab9 derivatives of amphomycin-type lipopepetide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.
Type:
Grant
Filed:
October 5, 2006
Date of Patent:
February 2, 2010
Assignee:
Migenix Inc.
Inventors:
Maria Fardis, Dale R. Cameron, Vincent A. Boyd
Abstract: Ring protector made from an elastic material and including a safety mesh. Ring protectors made according to principles of this invention protect rings from damage while at the same time keeping them on the wearers finger and avoiding slippage during active endeavors such as swimming.
Abstract: A surface-coated cutting tool comprising: a hard substrate; a lower layer which is formed on a surface of the hard substrate, contains a composite compound consisting of at least one element selected from Ti and Al, and at least one element selected from N and C, and has an average thickness of 0.1 to 3 ?m; and an upper layer having an average thickness of 1 to 13 ?m, which is formed on the lower layer and having a texture in which fine grains of crystalline Ti (C,N) based compounds or fine grains of crystalline (Ti, Al)(C, N) based compounds are dispersively distributed in a matrix of a carbon based amorphous material containing W.
Abstract: A system, apparatus, and method are directed to managing multiple back-end connections for pipelined HTTP communications. A traffic management device is configured to open back-end connections to multiple servers. The traffic management device distributes HTTP requests from a client device across multiple server connections. Instead of buffering the responses to ensure that each are returned in a same order as the requests, the traffic management device throttles a TCP receive window between all of the back-end server connections, but that back-end server connection associated with a first expected response. As each response is sent to the client device, the TCP window for the next back-end server connection is opened. This effectively offloads any significant buffering onto the back-end servers, enabling the traffic management device to return the responses in the same order as the requests.
Type:
Grant
Filed:
May 27, 2005
Date of Patent:
February 2, 2010
Assignee:
F5 Networks, Inc.
Inventors:
Jesse Abraham Rothstein, Arindum Mukerji
Abstract: The present invention discloses a method of providing data redundancy for HLR, the method comprises: performing cutover for subscribers' data preserved in master HLRs into a redundant center HLR; preserving all successfully executed operation & maintenance commands which are associated with system data and said subscribers' data of the master HLRs during runtime of the master HLRs; transferring said operation & maintenance commands preserved in the master HLRs to the redundant center HLR; converting the received operation & maintenance commands into internal operation commands recognizable by the redundant center HLR, and loading them into a host machine of the redundant center HLR. The present invention enhances the conformity of the subscribers' data, and reduces the maintenance workload of the redundant center HLR and lowers the maintenance complexity.
Abstract: Mouth adapter (1) for oral administration of a fluid mixture, comprising a generally elongate body (10) having a proximally disposed handle end (12) and a distally disposed outlet end (11); a lumen (15) provided in said body (10) adapted for receiving a syringe (2), said syringe (2) comprising a tip (24) extending from a distal end wall (23); and an outlet (16) in communication with said lumen (15) provided in said outlet end (11), wherein said outlet end (11) has a rounded, smooth and substantially rigid outer surface (50), the mouth adapter (1) being provided with stop means (40, 41, 42, 43) for preventing said tip (24) from extending from the exterior surface of the outlet end (11).
Abstract: The present invention relates to a novel and useful galactose derivative constituting a drug carrier by which a medicine can be efficiently transferred into the liver, a drug carrier comprising the derivative, and a pharmaceutical composition comprising the carrier and a medicine. The present invention also relates to a galactose derivative made up of galactose, a suitable spacer and a certain lipid, a drug carrier comprising the derivative and a cationic lipid, and a pharmaceutical composition comprising the carrier and a medicine (preferably a double-stranded RNA, a double-stranded DNA, or an oligo nucleic acid).
Abstract: The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
Type:
Grant
Filed:
August 29, 2008
Date of Patent:
February 2, 2010
Assignee:
Shire LLC
Inventors:
Travis Mickle, Suma Krishnan, Barney Bishop, Christopher Lauderback, James Scott Moncrief, Robert Oberlender, Thomas Piccariello, Bernhard J. Paul, Christopher A. Verbicky
Abstract: A method for automatically indicating status information of a measuring system via an output device includes assigning status information to respective status ranges according to at least one predetermined condition, the status ranges being limited by at least one threshold value. The status ranges are individually outputted. The status information is automatically updated at a predetermined time interval.
Type:
Grant
Filed:
February 21, 2003
Date of Patent:
February 2, 2010
Assignee:
Deutsche Telekom AG
Inventors:
Ralf Widera, Cornelius Heidemann, Joachim Mende, Heinrich Doerken
Abstract: A process for killing microorganisms and controlling biofouling in high chlorine demand waters comprises mixing two components, one of which is an oxidant and the other an ammonium salt, and adding the mixture immediately to the aqueous system to be treated.
Abstract: In a vacuum cleaner blower (1) consisting of an electric drive motor (2) and a support cage (10) for receiving the structural modules of the drive motor such as stator pack (6), rotor (7) and brush holders (8) including carbon brushes (9) as well as an at least single stage blower unit driven by the motor including a deflector (11), impeller (12) and suction hood (4), the deflector being formed as a support cage lid including a bearing seat for the rotor (7) and the support cage (10) being formed for a mounting direction (C) of its structural modules in the axial direction of the blower and for direct contacting and the brush holder (8) of the carbon brushes being provided adjacent to the upper side (B) of the support cage which also faces the deflector (11).
Type:
Grant
Filed:
October 27, 1999
Date of Patent:
January 26, 2010
Assignee:
Miele & Cie. KG
Inventors:
Guenter Esch, Peter Rode, Hans-Joachim Hegemann
Abstract: The present invention relates to a method and a plant for the heat treatment of solids containing titanium and possibly further metal oxides, in which fine-grained solids are heated to a temperature of 700 to 950° C. in a fluidized bed reactor (1). To improve the energy utilization, it is proposed to introduce a first gas or gas mixture from below through a gas supply tube (3) into a mixing chamber (7) of the reactor (1), the gas supply tube (3) being at least partly surrounded by a stationary annular fluidized bed (10) which is fluidized by supplying fluidizing gas. The gas velocities of the first gas or gas mixture as well as of the fluidizing gas for the annular fluidized bed (10) are adjusted such that the particle Froude numbers in the gas supply tube (3) are between 1 and 100, in the annular fluidized bed (10) between 0.02 and 2 and in the mixing chamber (7) between 0.3 and 30.
Type:
Grant
Filed:
December 10, 2003
Date of Patent:
January 26, 2010
Assignee:
Outotec Oyj
Inventors:
Dirk Nuber, Michael Ströder, Werner Stockhausen, Ali-Naghi Beyzavi, Lothar Formanek, Martin Hirsch
Abstract: A method and apparatus for treating an effluent containing radioactive materials: wherein an oxidizing agent is added to an effluent containing radioactive materials, and the effluent including the oxidizing agent is filtered with a filtration film to obtain filtrated water; and the filtrated water is filtered through activated carbon; and the filtered water filtered by the activated carbon is filtered through at least one of an ion-exchanger and reverse osmosis membrane.
Abstract: An oil for dust adsorption that includes a base oil (A), a nonionic surfactant (B), and an allergen inactivation component (C). This oil for dust adsorption can be used favorably on cleaning and wiping implements containing a dry fibrous substrate, such as mops and wipers and the like.
Type:
Grant
Filed:
December 27, 2005
Date of Patent:
January 26, 2010
Assignees:
Unicharm Corporation, Sanyo Chemical Industries, Ltd.
Abstract: The present invention relates to a compound represented by formula (1): (wherein, R1, R2, R3 and R4 respectively and independently represent a hydrogen atom or a C1-6 alkyl group, and n represents an integer of 1 or 2) and a production process thereof, as well as an antioxidant that contains the compound as its active ingredient, and a kidney disease treatment agent, cerebrovascular disorder treatment agent, retina oxidative disorder inhibitor and lipoxygenase inhibitor that contain the antioxidant.
Abstract: A method and apparatus for managing dynamic content processing in a reverse proxy server. The reverse proxy server may include modules for handling dynamic links, invalid or incorrect HTML code, and the like, in HTTP data. The reverse proxy server may further accept user- or administrator-defined specific modules for handling HTTP data. Upon receiving the HTTP data from the host server in response to a request from a client, the reverse proxy server determines whether pre-patching module(s) or post-patching module(s) are to be executed. Depending on the determination specific modules are executed before, after, or before and after generic patching. In one embodiment, the modules may include tags for automatic starting of an application tunnel, when an application requiring an application tunnel is to be launched at a host server.
Abstract: A method for easily and efficiently removing ruthenium complexes, which are generally difficult to remove, from a polymer, as well as a method for purifying a polymer that uses such a removal method are provided. A method for removing a metal, wherein a compound is added that is capable of coordination via a substitution of a ligand of a ruthenium complex, thereby precipitating another ruthenium complex, as well as a method for purifying a polymer that uses such a method.
Abstract: The present invention provides compounds having in their molecule a structure contributing to high hydrophilicity, and having high photopolymerizability, as well as polymers of such compounds, and a method for producing the compound. The compounds are diol (meth)acrylate having a urethane bond represented by the formula (1), and cyclic ketal (meth)acrylate having a urethane bond represented by the formula (2): (R1: H, —CH3; R2: —(CH2)n-; R3: —(CH2)m-; n: 1-4; m: 1-8; (AO): C2-C4 oxyalkylene group; x: 0-1000; R4, R5: H, —CH3, —C2H5).
Abstract: A sanitary napkin includes: a napkin body having a liquid-absorbent layer for absorbing and retaining liquid; and first and second projections each exerting an elastic contractive force between longitudinally opposing front and rear ends to concavely curve the body surface of the napkin body and raise itself from the body surface of the napkin body. The napkin body has an overlap region where the second projections lie on laterally opposite sides of the first projection.