Patents Represented by Attorney Dardi & Herbert, PLLC
  • Patent number: 8105532
    Abstract: Ultraviolet light is an effective sterilization agent. Convenient mobile sterilization devices are described herein that, in certain embodiments, provide indications to a user of how much sterilizing light is required for a given sterilization goal and how much light has been applied to a surface towards that goal. Users can move the devices across a target surface as needed to sterilize or disinfect the surface, with the device tracking the dosage applied to the surface. One embodiment of a mobile device that comprises an ultraviolet C (UVC) light source, a distance detector, an indicator, and a microprocessor that receives data from the distance detector for calculating an intensity of the light from the source on a target surface and for calculating a dosage of the light on the surface to provide a signal to the indicator when a predetermined dosage is achieved.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: January 31, 2012
    Assignee: Verilux, Inc.
    Inventors: Nicholas Harmon, Ryan Douglas
  • Patent number: 8101196
    Abstract: The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example, methacrylates. The macromers may also be made into polymers of at least two macromers polymerized together. These polymers are preferably multi-armed or high-molecular weight and used for medical uses, for example, making coatings on medical devices. Macromers of N-vinylpyrrolidone are also disclosed herein.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: January 24, 2012
    Assignee: BioInteractions, Ltd.
    Inventors: Ajay K. Luthra, Shivpal S. Sandhu, John O. Hudson
  • Patent number: 8100961
    Abstract: A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents employ certain unique properties of phenolic compounds to develop a protocol for reducing elastin degradation, such as that occurring during aneurysm formation in vasculature. According to the invention, elastin can be stabilized in vivo and destruction of connective tissue, such as that leading to life-threatening aneurysms in vasculature, can be tempered or halted all together. The treatment agents can be delivered or administered acutely or chronically according to various delivery methods, including sustained release methods incorporating perivascular or endovascular patches, use of microsphere carriers, hydrogels, or osmotic pumps.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: January 24, 2012
    Assignee: Clemson University Research Foundation (CURF)
    Inventors: Narendra R. Vyavahare, Jason C. Isenburg, Dan T. Simionescu
  • Patent number: 8048523
    Abstract: Nanoscale UV absorbing particles are described that have high UV absorption cross sections while being effectively transparent to visible light. These particles can be used to shield individuals from harmful ultraviolet radiation. These particles can also be used in industrial processing especially to produce solid state electronic devices by creating edges of photoresist material with a high aspect ratio. The UV absorbing particles can also be used as photocatalysts that become strong oxidizing agents upon exposure to UV light. Laser pyrolysis provides an efficient method for the production of suitable particles.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: November 1, 2011
    Assignee: NanoGram Corporation
    Inventors: Nobuyuki Kambe, Xiangxin Bi
  • Patent number: 8044137
    Abstract: Certain embodiments of the invention include forming a material in situ by introducing into a space within a patient a water soluble polymer precursor of at least about 10,000 molecular weight solubilized in a flowable aqueous solution. Functional groups on the polymer precursor undergo covalent bonding in situ to form a solid and nonbiodegradable material having a swellability less than about 20% v/v and a Young's modulus of at least about 100 kPa within about 30 seconds to about 30 minutes of initiating a chemical reaction of the functional groups to form the solid material.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: October 25, 2011
    Assignee: Incept LLC
    Inventors: Farhad Khosravi, James Dreher
  • Patent number: 8041638
    Abstract: In some aspects, what is disclosed relates to a processor-based payment method for transferring user-provided payment data through a router that parses the payment data and transfers the parsed data to a plurality of receivers in distinct locations, detecting the parsed data at each of the plurality of receivers, and originating an ACH debit against the user, or an e-check, based on the parsed data.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: October 18, 2011
    Inventor: Daniel King
  • Patent number: 8021689
    Abstract: Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics.
    Type: Grant
    Filed: February 19, 2007
    Date of Patent: September 20, 2011
    Assignee: Ecole Polytechnique Federale de Lausanne (“EPFL”)
    Inventors: Sai T. Reddy, Jeffrey A. Hubbell, Melody A. Swartz, André van der Vlies
  • Patent number: 8010534
    Abstract: Techniques for grouping related objects such as documents and files using quantum clustering are disclosed. A method may include constructing a feature-object database of multiple objects. The feature-object database may have quantized selected features as keys. A connected objects database maybe built. Clusters of connected objects may be identified in the connected objects database. The clusters of identified objects may be evaluated to determine groups of related objects. The method may be implemented on a computing device.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: August 30, 2011
    Assignee: Orcatec LLC
    Inventors: Herbert L. Roitblat, Brian Golbère
  • Patent number: 8003705
    Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable, or not, are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers. Embodiments that include hydrogels having isolated hydrolytically degradable esters are set forth.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: August 23, 2011
    Assignee: Incept LLC
    Inventors: Amarpreet S. Sawhney, Steven Bennett, Peter G. Edelman
  • Patent number: 7997951
    Abstract: Materials and methods for making and using a bird call device involving a surface having a central axis perpendicular to the surface and an opening that is displaced from the central axis by a distance, with the opening being shaped to emit a bird call when the surface is rotated about the central axis.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: August 16, 2011
    Assignee: Loontune, Inc.
    Inventor: Russell Rooney
  • Patent number: 7993947
    Abstract: Highly uniform silica nanoparticles can be formed into stable dispersions with a desirable small secondary particle size. The silican particles can be surface modified to form the dispersions. The silica nanoparticles can be doped to change the particle properties and/or to provide dopant for subsequent transfer to other materials. The dispersions can be printed as an ink for appropriate applications. The dispersions can be used to selectively dope semiconductor materials such as for the formation of photovoltaic cells or for the formation of printed electronic circuits.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: August 9, 2011
    Assignee: NanoGram Corporation
    Inventors: Henry Hieslmair, Shivkumar Chiruvolu, Hui Du
  • Patent number: 7996367
    Abstract: The exchange of documents for execution can be performed efficiently using an automated system that routes and stores documents based on routing information. Routing may be accomplished with reminders for individuals of deadline for responding. After execution is confirmed, an executed copy may be forwarded to all parties and desired non-parties. If execution or approval is desired from a plurality of individuals, documents received from each of the plurality of individuals can be merged into a single, fully executed document if the approval/signatures are obtained simultaneously. Search capability for identifying data regarding the document, text within the document, or both may also be provided.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: August 9, 2011
    Assignee: Echosign, Inc.
    Inventors: Dan A. Foygel, Jason M. Lemkin, Jeffrey M. Zwelling
  • Patent number: 7996439
    Abstract: The exchange of documents for signature can be performed efficiently using an automatic routing system that associates a document with appropriate identifying metadata. The routing can be facilitated through facsimile in which the metadata is encoded on a return facsimile cover sheet that is routed with the document. Appropriate central exchange servers have appropriate input and out subsystems to perform the document routing. The executed documents can be conveniently archived for efficient document storage and access, such as network access to one or more of the parties.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: August 9, 2011
    Assignee: Echosign, Inc.
    Inventors: Dan A. Foygel, Jason M. Lemkin, Jeffrey M. Zwelling
  • Patent number: 7988705
    Abstract: An integrated guiding device has a tube and a corewire within the tube and a torque coupler. The torque coupler can couple the rotational motion of the tube with the rotational motion of the corewire. The wire can be moved longitudinally at least some amount relative to the tube. The device can further comprise a functional medical structure, such as an embolism protection structure. The device can be used in medical procedures, such as less invasive procedures within the cardiovascular system. Improved fiber based embolism protection devices comprise fiber bundles that are twisted prior to delivery.
    Type: Grant
    Filed: November 2, 2004
    Date of Patent: August 2, 2011
    Assignee: Lumen Biomedical, Inc.
    Inventors: Jason A. Galdonik, James Pokorney, Matthew F. Ogle
  • Patent number: 7976516
    Abstract: A biocompatible medical device having a segmented element including a first segment having a first shaped interface and a second segment having a second shaped interface configured to operably couple the first shaped interface. When the first shaped interface is engaging the second shaped interface to form a joined segmented element, the first segment and the second segment cannot be decoupled by movement along an axis through the element. The medical device further includes a locking element configured to engage the joined segmented element with a sliding motion to prevent decoupling of the first segment with respect to the second segment by preventing significant relative movement of the segments with a component of the movement perpendicular to the axis.
    Type: Grant
    Filed: June 21, 2005
    Date of Patent: July 12, 2011
    Assignee: Lumen Biomedical, Inc.
    Inventors: Jason A. Galdonik, James Pokorney, Matthew F. Ogle
  • Patent number: 7972691
    Abstract: Successful dispersion approaches are described for the formation of dispersion of dry powders of inorganic particles. In some embodiments, it is desirable to form the dispersion in two processing steps in which the particles are surface modified in the second processing step. Composites can be formed using the well dispersed particles to form improved inorganic particle-polymer composites. These composites are suitable for optical applications and for forming transparent films, which can have a relatively high index or refraction. In some embodiments, water can be used to alter the surface chemistry of metal oxide particles.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: July 5, 2011
    Assignee: NanoGram Corporation
    Inventors: Shivkumar Chiruvolu, Hui Du, Nobuyuki Kambe
  • Patent number: 7938820
    Abstract: Thrombectomy catheters are presented that have curved tip portions. A suction lumen extends from at or near the proximal end of the catheter to a suction port at or near the tip portion of the catheter. The curves of the thrombectomy catheter can be selected to place a suction port at or near a vessel wall for the more effective removal of thrombus resulting from directing the suction in the direction of the thrombus. In some embodiments, the tip portion of the catheter can be transitioned from a first configuration for delivery of the catheter into the vessel to a second more curved configuration with a desired design for application of suction. The catheter can be moved in a circumferential and/or lateral direction to cover selected portions of the inner vessel wall. In some embodiments, a partially occlusive structure can be used to reduce and/or redirect flow within the vessel to improve performance of the thrombectomy.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: May 10, 2011
    Assignee: Lumen Biomedical, Inc.
    Inventors: Mark W. L. Webster, Jason A. Galdonik, Matthew F. Ogle
  • Patent number: 7938423
    Abstract: An exercise cycle and a method of using the exercise cycle, in which motion from the user's twisting of the torso and alternate pushing on hand grips are transmitted to the driving shaft for movement of the cycle. The exercise cycle comprises a frame, a front wheel, a first rear wheel, a second rear wheel, a seat, operator handles, hand grips, foot force plates, and a driving device. The driving device consists of a driving shaft, a force plate, pivotal arms, an elongate member, and a disk. The input of the user by torso twisting movement or pushing on handgrips will cause the cycle to move forward or backward.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: May 10, 2011
    Inventor: Leroy Schwartz
  • Patent number: 7919112
    Abstract: Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described. Also described are the methods and compositions wherein the tissue is fixed using biodegradable crosslinkers. Methods and compositions for making radio-opaque tissue are also described. Methods and compositions to obtain a degradable implantable tissue-synthetic biodegradable polymer composite are also described. Compositions and methods of incorporating substantially water-insoluble bioactive compounds in the implantable tissue are also disclosed. The use of membrane-like implantable tissue to make an implantable drug delivery patch are also disclosed. Also described are the compositions and methods to obtain a coated implantable tissue. Medical applications implantable tissue such as heart valve bioprosthesis, vascular grafts, meniscus implant, drug delivery patch are also disclosed.
    Type: Grant
    Filed: August 24, 2005
    Date of Patent: April 5, 2011
    Assignee: Pathak Holdings, LLC
    Inventors: Chandraskekhar P. Pathak, Sanjay M. Thigle
  • Patent number: 7919583
    Abstract: Some aspects of the application describe materials and methods for making a molecular tether. A molecular tether, in certain embodiments, includes a target-DNA-binding domain having a specific binding affinity for a target-DNA segment in a host chromosome, a carrier-binding domain that specifically binds to a DNA segment on a carrier, and a spacer covalently bonded to the target DNA-binding domain and the carrier-binding domain.
    Type: Grant
    Filed: August 8, 2005
    Date of Patent: April 5, 2011
    Assignee: Discovery Genomics, Inc.
    Inventors: Perry B. Hackett, Jeffrey Essner