Patents Represented by Attorney, Agent or Law Firm David A. Kalow, Esq.
  • Covalent attachment of unmodified nucleic acids to silanized solid phase surfaces
    Patent number: 6387626
    Abstract: The invention relates to a simple, cost effective method for immobilizing synthetic nucleic acid molecules onto a solid support The invention further concerns the use of such immobilized molecules in nucleic acid hybridization assays, sequencing by hybridization assays, and genetic analyses and combinatorial analyses involving nucleic acids or proteins for screening applications.
    Type: Grant
    Filed: August 14, 2000
    Date of Patent: May 14, 2002
    Assignee: Orchid BioSciences, Inc.
    Inventors: Jufang Shi, Michael T. Boyce-Jacino
  • Coated titanium dioxide pigments and processes for production and use
    Patent number: 6342099
    Abstract: The present invention provides a coated titanium dioxide pigment which includes a base titanium dioxide pigment; a first deposit of a phosphate compound contiguous with the base titanium dioxide pigment; a deposit of a silica or zirconia compound contiguous with the phosphate deposit; a second deposit of a phosphate compound contiguous with the silica or zirconia compound; and a deposit of an alumina compound contiguous with the second phosphate deposit. Titanium dioxide pigments of the present invention are easily dispersible, and display excellent durability and gloss.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: January 29, 2002
    Assignee: Millennium Inorganic Chemicals, Inc.
    Inventors: Michael Hiew, Philip Chegwidden
  • Nucleotide analogues with 3'-pro-fluorescent fluorophores in nucleic acid sequence analysis
    Patent number: 6287821
    Abstract: The invention concerns a novel class of 3′-modified, pro-fluorescent nucleotides. The invention also pertains to methods for using such nucleotides.
    Type: Grant
    Filed: June 11, 1998
    Date of Patent: September 11, 2001
    Assignee: Orchid BioSciences, Inc.
    Inventors: Jufang Shi, Michael T. Boyce-Jacino, Phillip Goelet