Abstract: 5-phenoxy-2-pyridinecarbonitrile compounds, which are useful as pharmacological agents, especially as agents for the reversal of amnesia, and methods for their preparation are disclosed. Pharmaceutical compositions containing said compounds and methods for using said compositions in treating senility and reversal of amnesia are also taught.

Abstract: A method is described for joining a capsule having a body and a cap comprising the steps of telescoping the cap onto the ridge of the body part, applying a pasty solidifying sealing composition onto the inner side of the capsule in the form of a strand, in the area of the ridge.

Abstract: A method is provided of manufacturing a joined telescoping vented cap-and-body capsule filled with viscous material, comprising the steps of filling the viscous material into the body part, closing the filled body part with a layer of pasty sealing composition which is inert to the viscous material, telescoping the cap and closed body part, and sealing the inner side of the cap to the body part.

Abstract: 2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone, 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one and acid-addition salts thereof are disclosed. 2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone and its acid-addition salts are prepared by catalytically reducing an acid-addition salt of 2-amino-1-[5-amino-1-(protected)-1H-imidazol-4-yl]ethanone. 6,7-Dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one and its acid-addition salts are prepared by reacting an acid-addition salt of 2-amino-1-(5-amino-1H-imidazol-4-yl)ethanone with a compound able to contribute a formyl group. The later product may subsequently be converted into (R)-3-(2-deoxy-.beta.-D-erythropentofuranosyl)-3,6,7,8-tetrahydroimidazo[4 ,5-d][1,3]diazepin-8-ol. Furanose derivatives of 6,7-dihydroimidazo[4,5-d][1,3]diazepine are also disclosed and their methods of preparation. Lastly, a method for resolving an isomer mixture of 3-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4 ,5-d][1,3]diazepin-8-ol compounds is related.

Abstract: 3,4-Dihydro-10-[2-(dialkylamino)ethyl]-1-phenyl-1H-thiazino[4,3-a]indol-4-o l compounds having in free base form the formula ##STR1## where R.sub.1 and R.sub.2 are lower alkyl groups. The compounds of this invention exhibit anti-allergy properties and are indicated in the management of allergy.

Abstract: 3-Aryloxy-2-pyridinecarbonitrile 1-oxide compounds, which are useful as pharmacological agents, especially as agents for the reversal of amnesia, are disclosed. The compounds can be produced by oxidizing a 3-aryloxy-2-pyridinecarbonitrile.

Abstract: 3-Aryloxy-1-carboalkoxyethylpyridinium compounds, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, are disclosed. The compounds can be produced by reacting 3-aryloxypyridine with an alkyl acetate containing a displaceable group.

Abstract: A prosthetic preform comprised of a hard base into which are molded the posterior prosthetic teeth, with the anterior prosthetic teeth being mounted in a waxy material contained in a cavity or cavities disposed in the hard base. The preform is further provided with a formable deflectable layer secured to the hard base structure and adapted to be fit to the general contours of the wearer's mouth with an impression material used to line the tissue surface of the deflectable layer to obtain an impression of the intimate detail of the edentulous tissue. The anterior teeth may thus be adjusted in position during fitting and/or anatomical features carved. A mold is made of the anterior teeth and exposed waxy material after fitting which allows casting the fitted anterior teeth in hard base material to the remainder of the hard base structure.

Abstract: Cleaning apparatus for filled capsules including in combination a rotary drum for tumbling the capsules, napped or tufted fabric liner means for the drum such that uncleaned capsules during tumbling are rubbed by the nap of the fabric and are thereby cleansed of particulate matter, and vacuum means for removing particulate matter from the nap of the fabric; and a process for cleaning filled capsules.

Abstract: 3-Aryloxy-substituted-aminopyridines and salts thereof, which are useful as pharmacological agents, especially cognition activators, are disclosed. They can be produced by reacting a chloro-3-aryloxypyridine with a substituted amine, 3-bromo-substituted-aminopyridine with an alkali metal salt of a phenol compound or by deoxygenation of a 3-aryloxy-substituted-aminopyridine N-oxide.

Abstract: Pyridobenzodioxin compounds, which are useful as pharmacological agents, especially as agents for the treatment of senility and reversal of amnesia, and methods for their preparation are disclosed. Pharmaceutical compositions containing said compounds and methods for using said compositions in treating senility and reversal of amnesia are also taught.

Abstract: An intravenous catheter apparatus comprising an intravenous catheter tube, a manually guidable circumferentially deformable elastomeric bore-defining tubular inserter integral with and in axial alignment with the catheter tube for use with a patient, and a needle concentric within the catheter tube and inserter and extending through at least part of the bore of the inserter to beyond the distal end of the catheter tube, the inserter comprising opposed laterally extending wings adapted to be manually compressed together from an at-rest position to a needle control position, the bore of the inserter being sufficiently large to permit retraction of the needle from the catheter tube and the inserter when the inserter is at rest, and when the inserter wings are compressed to the needle control position being sufficiently constricted to enable the inserter to grip the needle firmly to permit inserter-forced injection of the distal end of the needle into the body of a patient.

Abstract: A complete denture is disclosed for both maxillary and mandibular prostheses of the type having a hard base structure formed of acrylic plastic into which prosthetic teeth are set, the hard base structure fused to a deflectable tray layer of thermo plastic material which is deflectable when warm to adapt the denture to the general contours of the maxillary or mandibular ridges, a subsequent coating of autopolymerizing acrylic plastic being applied to the tray providing precise fitting of the denture to the oral contours of the wearer and stabilizing the soft deflectable tray in its newly achieved configuration.

Abstract: Antihemophilic factor (AHF) concentrate having enhanced potency and solubility and its process of production are provided. The process includes the steps of removing unwanted protein from an aqueous extract of antihemophilic blood plasma cryoprecipitate by mixing the aqueous extract with aluminum hydroxide at an acid pH in the cold, adjusting the purified aqueous extract to an acid pH and freeze-drying the extract, optionally removing water from the extract just before freeze-drying.

Abstract: 3,3'-Thiodimethylenebis 2-[(dialkylamino)methyl]indole compounds having in free base form the formula ##STR1## where R.sub.1 and R.sub.2 are lower alkyl groups. The compounds of this invention exhibit antifungal and CNS depressant properties and can be used as antifungal agents or CNS depressant agents.

Abstract: .beta.-[2-[(DIALKYLAMINO)METHYL]-1H-indol-3-yl]-.alpha.,.alpha.-diphenylpro pionitriles and 4-[[2-[(dialkylamino)methyl]-1H-indol-3-yl]methyl]-2,4-dihydro-5-lower alkyl-2-phenyl-3H-pyrazol-3-ones and acid addition salts thereof which are useful pharmacological agents, especially as central nervous system depressants, are disclosed. The compounds can be produced by reacting an anion of an acetonitrile or a pyrazol-3-one with the appropriate quatenary salt of 2-alkyl-1,2,3,4-tetrahydropyrrolo[3,4-b]indole.

Abstract: 3-[2-(Dialkylamino)ethyl]-2-(benzyl)indoles having in free base form the formula ##STR1## where R.sub.1 and R.sub.2 are lower alkyl groups and R.sub.3 is a phenyl, carboalkoxymethyl, lower alkyl or hydroxyethyl group. The compounds of the invention exhibit anti-aggression and anti-secretory properties and are indicated in the management of aggression and gastric hypersecretion.

Abstract: N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidineacetamides which are useful as pharmacological agents, especially cognition activators, are disclosed. They can be produced by reacting a 2-oxo-1-pyrrolidineacetate ester with an appropriate amine.

Abstract: O-2,6-Diamino-2,3,6-trideoxy-.alpha.-D-ribo-hexopyranosyl-(1.fwdarw.4)-O-?. beta.-D-xylofuranosyl-(1.fwdarw.5)!-N.sup.1 -?(S)-4-amino-2-hydroxy-1-oxobutyl!-2-deoxystreptamine, also known as 3'-deoxybutirosin A and acid addition salts of said compound. These compounds exhibit a wide spectrum of antibacterial activity.