Patents Represented by Attorney David B. Ran
  • Patent number: 7666832
    Abstract: Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: February 23, 2010
    Assignee: Amgen Inc.
    Inventors: Jonathan Daniel Oliner, Hosung Min
  • Patent number: 7528239
    Abstract: A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: May 5, 2009
    Assignee: Immunex Corporation
    Inventors: Charles Rauch, Henning Walczak
  • Patent number: 7455963
    Abstract: Disclosed are nucleic acid molecules encoding cyclin E2 polypeptides. Also disclosed are methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules.
    Type: Grant
    Filed: July 28, 2005
    Date of Patent: November 25, 2008
    Assignee: Amgen Inc.
    Inventors: Steven Roy Coats, Michael Brian Bass, Murray O. Robinson
  • Patent number: 6943238
    Abstract: Disclosed are nucleic acid molecules encoding novel cyclin E2 polypeptides. Also disclosed are methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: September 13, 2005
    Assignee: Amgen, Inc.
    Inventors: Steven Roy Coats, Michael Brian Bass, Murray O. Robinson
  • Patent number: 6613963
    Abstract: The invention is in the field of Brassica juncea breeding, specifically relating to the development of stable herbicide tolerant Brassica juncea lines, plants and plant parts, having a mutant AHAS1. A method of producing stable herbicide tolerant Brassica juncea lines, plants and plant parts is also provided.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: September 2, 2003
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Gregory R. Gingera, Jayantilal D. Patel, David G. Charne, Rakesh K. Arora
  • Patent number: 6472185
    Abstract: Methods of genotyping amplified mixtures of DNAs, nucleic acid markers and methods of obtaining markers, kits, recombinant plants, positional cloning and integrated systems for making genotypes and assessing hybridizations are provided. These features are applicable to DNA fingerprinting, marker assisted selection, genotyping, cladistic analysis of variance, and high throughput laboratory screening methods.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: October 29, 2002
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Rhonda J. McCasky Feazel, Timothy G. Helentjaris, Sharon E. Malmberg, Barry A. Martin
  • Patent number: 6421613
    Abstract: The invention provides isolated prolifera nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering prolifera levels in plants. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions.
    Type: Grant
    Filed: June 27, 2000
    Date of Patent: July 16, 2002
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Ramgopal Nadimpalli, Carl R. Simmons
  • Patent number: 6403084
    Abstract: Methods and compositions for treatment of animal feed or silage by treatment with a mixed culture of heterofermentive lactic acid bacteria and homofermentive lactic acid bacteria of the proper ratio. Bacterial strains for such treatment are also provided.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: June 11, 2002
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Russell Kuo-fu Chan, Scott Dennis, Elizabeth K. Harman, William Rutherford, Brenda Smiley
  • Patent number: 6368806
    Abstract: The invention provides a method of associating a gene or an expression product with a complexly inherited phenotypic trait of interest in a plant. Plants are segregated by the presence or absence of a genetic marker. One or more of the segregated groups are expression profiled to determine the gene associated with the phenotypic trait of interest. The gene associated with the phenotypic trait of interest can be identified and/or isolated.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: April 9, 2002
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Steve Openshaw, Wesley B. Bruce
  • Patent number: 6337068
    Abstract: A method for treating silage to enhance aerobic stability by inhibiting growth of microorganisms selected from yeasts, molds and spore-forming bacteria is disclosed. The method comprises treating silage or feed with a composition comprising Lactobacillus buchneri, LN 3957, or the antimicrobial components produced thereby. According to the invention, a strain of Lactobacillus has been purified and isolated which is nontoxic, safe and which improves aerobic stability of silage.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: January 8, 2002
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Carol A. Hendrick, Barbara G. Ruser, Cora R. Wortman, Scott M. Dennis
  • Patent number: 6300542
    Abstract: Insertions into a gene of known sequence can be generated by crossing two parent plants, one of which contains a transposable element, to produce F1 progeny plants in which the insertion is detected by means of a PCR. F1 progeny plants containing such an insertion are self-fertilized to produce F2 progeny which are homozygous for the insertion. The function of a gene disabled by the insertion can be ascertained from a comparison of the phenotype of the F2 progeny with a parental phenotype. Large numbers of F1 progeny can be tested simultaneously for the presence of insertions. A collection of F2 seed can be stored and used for phenotype comparison when an insertion is detected.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: October 9, 2001
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Steven P. Briggs, Robert B. Meeley
  • Patent number: 6162967
    Abstract: A method for introgressing soybean cyst nematode resistance into elite soybean germplasm is disclosed. The method involves using genetically mapped loci associated with soybean cyst nematode resistance for marker-assisted selection during introgression of soybean cyst nematode resistance into elite soybean germplasm. Also disclosed are a method for confirming selection for soybean cyst nematode resistance; quantitative trait loci associated with soybean cyst nematode resistance; and soybean lines bred to be resistant to soybean cyst nematode infestation. Also disclosed is a method for using the mapped markers for positional cloning of soybean cyst nematode resistance genes.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: December 19, 2000
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventor: David M. Webb