Patents Represented by Attorney, Agent or Law Firm David B. Schram
  • Compostions comprising viruses and methods for concentrating virus preparations
    Patent number: 6544769
    Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: April 8, 2003
    Assignee: Schering Corporation
    Inventors: Andreas Frei, Henry K. H. Kwan, Varda E. Sandweiss, Gary J. Vellekamp, Pui-Ho Yuen, Peter Ihnat
  • CML Therapy
    Patent number: 6362162
    Abstract: Methods for treating treatment-naive as well as treatment-experienced patients having CML to achieve at least a partial cytogenetic response involving administering a therapeutically effective amount of pegylated interferon-alpha, e.g., pegylated interferon alpha-2b as monotherapy or in association with a therapeutically effective amount of Ara-C are disclosed.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: March 26, 2002
    Assignee: Schering Corporation
    Inventors: Mary Ellen Rybak, Esther Helen Rose
  • Hepatitis C virus protease-dependent chimeric pestivirus
    Patent number: 6326137
    Abstract: A chimeric bovine viral diarrhea virus (BVDV) that depends on a hepatitis C virus (HCV). The invention further relates to using the chimeric, infectious virus to screen for HCV NS3 inhibitor compounds in cell culture models or in animal models of viral infection.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: December 4, 2001
    Assignee: Schering Corporation
    Inventors: Zhi Hong, Vicki C. H. Lai, Johnson Y. N. Lau
  • Treatment of neoplastic disease with interleukin-10
    Patent number: 6319493
    Abstract: A method is provided for treating tumors, e.g., lymphocytic leukemias, which comprises administering to a mammal an effective amount of interleukin-10.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: November 20, 2001
    Assignee: Schering Corporation
    Inventors: Paulo J. Vieira, Kevin W. Moore, Rene de Waal Malefyt, Jan E. de Vries, Anne-Catherine Fluckiger, Jacques Banchereau
  • De novo priming activity of hepatitis C virus replicase
    Patent number: 6297005
    Abstract: The present invention relates to identification of a novel, de novo priming activity of hepatitis C virus replicase. This activity can be used to screen for anti-HCV replicase compounds, or to characterize the biological relevance of lead compounds that have already been identified.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: October 2, 2001
    Assignee: Schering Corporation
    Inventors: Weidong Zhong, Zhi Hong, Annette Schettino Uss, Johnson Y. N. Lau
  • Methods for purifying viruses
    Patent number: 6261823
    Abstract: The invention provides methods for purifying a virus from impurities in an aqueous medium.
    Type: Grant
    Filed: December 11, 1997
    Date of Patent: July 17, 2001
    Assignee: Schering Corporation
    Inventors: John Chu-Tay Tang, Gary Vellekamp, Laureano L. Bondoc, Jr.
  • Binding compositions specific for interleukin-10
    Patent number: 6239260
    Abstract: Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs) or interleukin 10 (IL-10), as well as antibodies which specifically bind IL-10, are provided. These proteins, and antibodies, may be used to treat various disease states associated with cytokine imbalances.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 29, 2001
    Assignee: Schering Corporation
    Inventors: Timothy R. Mosmann, Kevin W. Moore, Martha W. Bond, Paulo J. M. Vieira
  • Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
    Patent number: 6217857
    Abstract: Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIF's, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-&ggr;.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 17, 2001
    Assignee: Schering Corporation
    Inventors: Timothy R. Mosmann, Kevin W. Moore, Martha W. Bond, Paulo J. M. Vieira
  • Methods of treatment using antagonists of cytokine synthesis inhibitory factor
    Patent number: 6207154
    Abstract: Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-&ggr;.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 27, 2001
    Assignee: Schering Corporation
    Inventors: Timothy R. Mosmann, Kevin W. Moore, Martha W. Bond, Paulo J. M. Vieira
  • Methods for cultivating cells and propagating viruses
    Patent number: 6146891
    Abstract: This invention relates to methods for the cultivating cells, and in particular to methods for propagating viruses.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: November 14, 2000
    Assignee: Schering Corporation
    Inventors: Russell G.G. Condon, Nancy V. Connelly, Andreas Frei, Edward Glowacki, Vijay Yabannavar, Serge Batandolo
  • Treatment of neoplastic disease with interleukin-10
    Patent number: 6106823
    Abstract: A method is provided for treating tumors, e.g., lymphocytic leukemias, which comprises administering to a mammal an effective amount of interleukin-10.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: August 22, 2000
    Assignee: Schering Corporation
    Inventors: Paulo J. Vieira, Kevin W. Moore, Rene de Waal Malefyt, Jan E. de Vries, Anne-Catherine Fluckiger, Jacques Banchereau
  • Method for treating or preventing ischemia-reperfusion injury
    Patent number: 6086868
    Abstract: There is disclosed a method of treating ischemia-reperfusion injury comprising administering an effective amount of Interleukin-10 to a patient suffering or expected to suffer from such injury.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: July 11, 2000
    Assignee: Schering Corporation
    Inventors: Lyle L. Moldawer, James M. Seeger, Timothy R. S. Harward, Satwant K. Narula