Patents Represented by Attorney, Agent or Law Firm David D. McMasters
  • Recombinant alphavirus particles
    Patent number: 6376236
    Abstract: Disclosed are recombinant alphavirus particles comprising a) an alphavirus vector construct which directs the expression of a heterologous nucleic acid molecule; b) a capsid protein; and c) an envelope glycoprotein from a virus different from said alphavirus vector.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: April 23, 2002
    Assignee: Chiron Corporation
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Carlos E. Ibanez, David A. Driver
  • Eukaryotic layered vector initiation systems for production of recombinant proteins
    Patent number: 6342372
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: January 29, 2002
    Assignee: Chiron Corporation
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, David A. Driver
  • Methods for purifying non-chromosomal nucleic acid molecules from cells
    Patent number: 6268492
    Abstract: Methods are provided for purifying non-chromosomal nucleic acid molecules from cells, comprising: the general steps of (a) lysing cells to form a nucleic acid-containing lysate, and (b) applying the lysate to a depth filter in order to obtain a clarified solution containing purified non-chromosomal nucleic acid molecules.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: July 31, 2001
    Assignee: Chiron Corporation
    Inventors: Denice M. Mittelstaedt, David Chi-Tang Hsu
  • Method for stimulating an immune response utilizing recombinant alphavirus particles
    Patent number: 6015694
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: January 18, 2000
    Assignee: Chiron Corporation
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Steven M.W. Chang, Douglas J. Jolly
  • Alphavirus vector constructs
    Patent number: 5843723
    Abstract: The present invention provides compositions and method,, for utilizing recombinant alphavirus vectors.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: December 1, 1998
    Assignee: Chiron Corporation
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Carlos E. Ibanez, Stephen M. W. Chang, Douglas J. Jolly, David A. Driver, Barbara A. Belli
  • Alphavirus structural protein expression cassettes
    Patent number: 5789245
    Abstract: The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: August 4, 1998
    Assignee: Chiron Corporation
    Inventors: Thomas W. Dubensky, Jr., John M. Polo, Carlos E. Ibanez, Stephen M. W. Chang, Douglas J. Jolly, David A. Driver
  • Interleukin-1 receptors
    Patent number: 5081228
    Abstract: Mammalian Interleukin-1 receptor proteins (IL-1Rs), DNAs and expression vectors encoding mammalian IL-1Rs, and processes for producing mammalian IL-1Rs as products of cell culture, including recombinant systems, are disclosed.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: January 14, 1992
    Assignee: Immunex Corporation
    Inventors: Steven K. Dower, Carl J. March, John E. Sims, David L. Urdal