Patents Represented by Attorney David E. Boone

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  • Benzo ?B! indeno ?2,1-D! thiophene compounds, intermediates, processes, compositions and methods
    Patent number: 5856341
    Abstract: The invention provides benzo?b!indenothiophene compounds of formula I ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6, are as defined in the specification, intermediates, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions including hyperlipidemia and related cardiovascular pathologies, and estrogen-dependent cancer.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: January 5, 1999
    Assignee: Eli Lilly and Company
    Inventors: Michael Gregory Bell, Brian Stephen Muehl, Mark Alan Winter
  • Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
    Patent number: 5852193
    Abstract: The invention relates to intermediates and processes for producing benzothiophenes employing hydroxylamines.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: December 22, 1998
    Assignee: Eli Lilly and Company
    Inventor: Erik Christopher Chelius
  • Method for treating anxiety
    Patent number: 5852036
    Abstract: The present invention provides a method for treating anxiety in humans using compounds which modulate a muscarinic receptor.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: December 22, 1998
    Assignee: Eli Lilly and Company
    Inventors: Neil C. Bodick, Franklin P. Bymaster, Walter W. Offen, Harlan E. Shannon
  • Anti-obesity proteins
    Patent number: 5851995
    Abstract: The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: December 22, 1998
    Assignee: Eli Lilly and Company
    Inventors: Margret B. Basinski, Richard D. DiMarchi, David B. Flora, William F. Heath, Jr., James A. Hoffmann, Brigitte E. Schoner, James E. Shields, David L. Smiley
  • Method for treating anxiety
    Patent number: 5852037
    Abstract: The present invention provides a method for treating anxiety in humans using azacyclic or azabicyclic compounds.
    Type: Grant
    Filed: October 22, 1996
    Date of Patent: December 22, 1998
    Assignee: Eli Lilly and Company
    Inventors: Neil C. Bodick, Franklin P. Bymaster, Walter W. Offen, Harlan E. Shannon
  • Carbamoyl substituted heterocycles
    Patent number: 5849766
    Abstract: This invention relates to carbamoyl substituted heterocycles which are .omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring and which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as pharmaceutical formulations containing them, methods for their use, and processes and intermediates for their preparation.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: December 15, 1998
    Assignee: Eli Lilly and Company
    Inventors: Joseph Anothony Jakubowski, Dale Eugene Mais, Kumiko Takeuchi
  • Preparation of substituted alkenoic acids
    Patent number: 5849922
    Abstract: This invention relates to a highly selective process for preparation of E-.omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as to intermediates therefor.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: December 15, 1998
    Assignee: Eli Lilly and Company
    Inventors: Katrina Ann Nelson, Joseph John Nunes
  • Methods of treating pulmonary hypertension
    Patent number: 5846973
    Abstract: This invention provides methods of inhibiting pulmonary hypertensive disease which comprise administering to a mammal in need thereof a compound having activity as a tachykinin receptor antagonist.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: December 8, 1998
    Assignee: Eli Lilly and Company
    Inventors: Donald Richard Gehlert, Mitchell Irvin Steinberg
  • Method for treating substance abuse withdrawal
    Patent number: 5846974
    Abstract: This invention provides a method for treating a condition resulting from the cessation or withdrawal of tobacco or nicotine, opioids, ethanol or combinations thereof comprising administering an effective amount of 4-chloro-5-(imidazoline-2-y(amino)-6-methoxy-2-methylpyrimidine.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: December 8, 1998
    Assignee: Eli Lilly and Company
    Inventors: Mary J. Kallman, Kurt Rasmussen
  • Inhibition of serotonin reuptake
    Patent number: 5846982
    Abstract: This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: December 8, 1998
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, Daniel J. Koch, Thomas E. Mabry, Jeffrey S. Nissen, Vincent P. Rocco, Yao-Chang Xu
  • Substituted 1, 2, 3, 4-tetrahydro-2-dibenzofuranamines and 2-amino-cyclohepta (6, 7-B) Benzofurans
    Patent number: 5846995
    Abstract: The invention provides substituted-2-amino-1,2,3,4-tetrahydrodibenzofurans and 2-aminocyclohepta?b!benzo-furans useful as 5-HT.sub.1F agonists.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: December 8, 1998
    Assignee: Eli Lilly and Company
    Inventors: Michael E. Flaugh, Anton D. Kiefer, Jr.
  • Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se
    Patent number: 5843974
    Abstract: A method of inhibiting melanoma comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino, or a pharmaceutically acceptable salt of solvate thereof; alone or in combination with one or more melanoma-inhibiting agents.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 1, 1998
    Assignee: Eli Lilly and Company
    Inventor: Robert A. Swift
  • A82846 antibiotics
    Patent number: 5843437
    Abstract: New glycopeptide antibiotic A82846, comprising A82846A, A82846B and A82846C, is produced by Nocardia orientalis strains NRRL 18098, NRRL 18099 and NRRL 18100. The A82846 antibiotics have activity against Gram-positive bacteria comparable to that of vancomycin.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 1, 1998
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, James A. Mabe, David F. Mahoney, Walter M. Nakatsukasa, Raymond C. Yao
  • Sulfated benzothiophene derivatives, methods of use and formulations containing same
    Patent number: 5843984
    Abstract: Sulfated benzothiophenes of the formula I ##STR1## wherein R.sup.1 is hydrogen, hydroxy, C.sub.1 -C.sub.4 alkoxy, --OCOO(C.sub.1 -C.sub.6 alkyl), --OCO(C.sub.1 -C.sub.6 alkyl), --OCOAr wherein Ar is phenyl or optionally substituted phenyl, --OSO.sub.2 (C.sub.4 -C.sub.6 straight chain alkyl), or --OSO.sub.3 H;R.sup.2 is R.sup.1, Cl or F; with the proviso that at least one of R.sup.1 or R.sup.2 is --OSO.sub.3 H;R.sup.3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; andn is 2 or 3;or a pharmaceutically acceptable salt or solvate thereof.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: December 1, 1998
    Assignee: Eli Lilly and Company
    Inventors: Michael Paul Clay, Charles Alan Frolik, Charles David Jones, Terry Donald Lindstrom
  • Protein kinase C inhibitors
    Patent number: 5843935
    Abstract: This invention provides novel bis-indolemaleimide macrocycle derivatives of the formula: ##STR1## The invention further provides the preparation, pharmaceutical formulations and the methods of use for inhibiting Protein Kinase C in mammals.
    Type: Grant
    Filed: July 12, 1997
    Date of Patent: December 1, 1998
    Assignee: Eli Lilly and Company
    Inventors: William F. Heath, Jr., Michael R. Jirousek, John H. McDonald, III, Christopher J. Rito
  • Glycopeptide antibiotic derivatives
    Patent number: 5843889
    Abstract: The present invention provides glycopeptide antibiotic derivative compounds. These derivative compounds possess antibacterial activity aginst a wide variety of bacteria, including activity against vancomycin-resistant isolates. Methods of making and using these glycopeptide antibiotic derivative compounds are also provided.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: December 1, 1998
    Assignee: Eli Lilly and Company
    Inventors: Robin D. G. Cooper, Bret E. Huff, Thalia I. Nicas, John T. Quatroche, Michael J. Rodriguez, Nancy J. Snyder, Michael A. Staszak, Richard C. Thompson, Stephen C. Wilkie, Mark J. Zweifel
  • Benzothiophene compounds, intermediates, processes, compositions, and methods
    Patent number: 5843963
    Abstract: The invention provides benzothiophene compounds, of formula I, ##STR1## wherein R1, R2, R3, R4 and n are as defined in the specification, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions, including hyperlipidemia, and other cardiovascular pathologies.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: December 1, 1998
    Assignee: Eli Lilly and Company
    Inventors: Kenneth Lee Hauser, Alan David Palkowitz, Kenneth Jeff Thrasher
  • Benzothiophene compounds, compositions, and method
    Patent number: 5843940
    Abstract: The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions including hyperlipidemia, and estrogen-dependent cancer.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: December 1, 1998
    Assignee: Eli Lilly and Company
    Inventors: George Joseph Cullinan, Brian Stephen Muehl
  • Treatment of atherosclerosis
    Patent number: 5843938
    Abstract: The use of a compound of the formula: ##STR1## in which X is --O-- or --NH--, or a pharmaceutically-acceptable acid addition salt thereof, in the treatment of atherosclerosis.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: December 1, 1998
    Assignee: Beiersdorf-Lilly GmbH
    Inventors: Hans-Juergen Mest, Wolfgang Stenzel
  • Methods of inhibiting endometrial mitoses
    Patent number: 5843964
    Abstract: A method of inhibiting endometrial mitoses comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: December 1, 1998
    Assignee: Eli Lilly and Company
    Inventor: Susan M. Boss