Patents Represented by Attorney, Agent or Law Firm David J. Brezner
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Patent number: 6808608Abstract: An apparatus for removing charged contaminants from a water stream. The apparatus can be figured to provide the decontaminated water stream to an analytical system. Methods of use of the same are also disclosed.Type: GrantFiled: March 13, 2002Date of Patent: October 26, 2004Assignee: Dionex CorporationInventors: Kannan Srinivasan, Nebojsa Avdalovic
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Patent number: 6752927Abstract: Method and apparatus for suppressed ion analysis in which a sample solution of analyte (e.g., anion) in an eluent of electrolyte counterions (e.g., sodium), is chromatographically separated. Then, the counterions are suppressed in a suppression zone and removed and used to convert the analyte ions to salt form in a salt-converting zone. The suppression and salt-converting zones may be contiguous or remote, and may be performed in devices of the membrane suppresser type. Thereafter, the salts or acids or bases formed from them (e.g., in membrane suppressor devices) are detected. Also, salt conversion can be performed using two ion exchange packed bed salt convertors in which one bed is on-line while the other is regenerated, followed by a reversal of flow.Type: GrantFiled: March 1, 2001Date of Patent: June 22, 2004Assignee: Dionex CorporationInventors: Kannan Srinivasan, Sheetal Saini, Nebojsa Avdalovic
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Patent number: 6750256Abstract: Methods and compositions based upon natural aromatic aldehydes are provided, which find use as pesticides. The pesticides are formulated in a variety of ways, including dusts, sprays, shampoos and soaps, and can be bound to a solid support or provided as bait or directly impregnated into organic matter infested by or susceptible to infestation by a target pest. Pests controlled include mosquitos, lice, ants, cockroaches, lice, and ticks.Type: GrantFiled: October 29, 1999Date of Patent: June 15, 2004Assignee: Proguard, Inc.Inventors: Bradford G. Crandall, Jr., Ralph W. Emerson
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Patent number: 6747135Abstract: The present invention is directed to novel polypeptides, termed fluorettes, that bind with high avidity to fluorophore dyes. The peptides find use in a variety of methods and approaches involving fluorophore dyes.Type: GrantFiled: October 15, 1999Date of Patent: June 8, 2004Assignee: The Board of Trustees for the Leland Stanford Junior UniversityInventors: Garry P. Nolan, Michael N. Rozinov
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Patent number: 6742278Abstract: The present invention relates to the treatment of wood, and is particularly concerned with a method for increasing the permeability of wood, especially moist wood.Type: GrantFiled: May 8, 2003Date of Patent: June 1, 2004Assignee: The University Of MelbourneInventors: Peter Vinden, Francisco Javier Romero, Grigory Torgovnikov
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Patent number: 6682701Abstract: Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.Type: GrantFiled: July 7, 2000Date of Patent: January 27, 2004Assignee: Dionex CorporationInventors: Yan Liu, Hamish Small, Nebojsa Avdalovic
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Patent number: 6645378Abstract: A modified silica support having a polar phase bound to its surface and suitable for use for chromatographic separations, having the following formula: wherein, m=0-20; n=0-20; p=1-50; X is sulfonyl, carbonyl, carbamoyl, or oxycarbonyl; R1=H, alkyl, substituted alkyl, aryl or substituted aryl groups; R2=alkyl, substituted alkyl, aryl or substituted aryl groups; and R3 and R4 are alkyl, aryl, hydroxyl, or alkoxyl groups or groups including oxygen atoms cross-linked to silicon atoms. Also, a polar silane intermediate to make this support.Type: GrantFiled: March 5, 2002Date of Patent: November 11, 2003Assignee: Dionex CorporationInventors: Xiaodong Liu, Andrei V. Bordunov
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Patent number: 6632681Abstract: A device and method for filtering a biologically derived sample and for mixing the sample with a reagent, comprising a fluid container defining a reservoir compartment and including a container outlet, a filter and a fluid flow-through matrix disposed in a flow path between the reservoir compartment and the container outlet. Water-soluble, dried reagent is retained on the matrix. Means is provided for urging sample in an aqueous liquid in the reservoir compartment through the filter and matrix and out the container outlet. Pressure is applied to the sample in an aqueous liquid in the reservoir compartment to cause the sample to flow in liquid through the filter and matrix and out of the container for analysis.Type: GrantFiled: July 24, 2000Date of Patent: October 14, 2003Assignee: EY LaboratoriesInventor: Albert E. Chu
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Patent number: 6610546Abstract: An electrolytic suppressor including (a) packing (a suppressor bed of ion exchange resin or a flow-through monolith), (b) an electrode chamber adjacent the suppressor, (c) a first electrode in the electrode chamber, (d) a barrier separating the packing from the first electrode chamber preventing significant liquid flow but permitting transport of ions only of the same charge as the packing, (e) a second electrode in electrical communication with the resin bed, and (f) a recycle conduit between the suppressor outlet port and said electrode chamber. Charged transverse partitions with openings may be included to create a serpentine liquid path.Type: GrantFiled: August 25, 2000Date of Patent: August 26, 2003Assignee: Dionex CorporationInventors: Yan Liu, Kannan Srinivasan, Nebojsa Avdalovic, Hamish Small, John M. Riviello
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Patent number: 6596975Abstract: A method for increasing the permeability of wood which comprises subjecting wood with a moisture content (based on dry weight) of at least 15% to microwave radiation at a frequency (f) in the range of from about 0.1 to about 24 GHz with a power intensity (p) from about 10 W/cm2 to about 100 kW/cm2 for a duration of from about 0.05 to about 600 seconds to cause water in the wood to vaporise resulting in an internal pressure in the wood such that the permeability of the wood is increased by partial or complete destruction of ray cell tissue, softening and displacement of wood resin, formation of pathways in the radial direction of the wood and/or by creating, on the base of destroyed rays, cavities in the wood, said cavities being primarily in radial-longitudinal planes of the wood, and wherein the overall integrity of the wood is substantially maintained. A wood-based material may be formed having a permeability which is at least 5 times that of the untreated wood.Type: GrantFiled: February 12, 2001Date of Patent: July 22, 2003Assignee: The University of MelbourneInventors: Peter Vinden, Francisco Javier Romero, Grigory Torgovnikov
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Patent number: 6562628Abstract: A combination electrolytic suppressor and separate eluent generator and method. The suppressor includes a chromatography effluent flow channel, an ion receiving flow channel, and a first suppressor ion exchange barrier therebetween permeable to electrolyte ions but not liquid flow. The effluent from the chromatography effluent compartment flows through the detector, the ion receiving channel, and to an eluent generator. The generator includes a first generator electrode in a first generator electrode chamber, an electrolyte ion reservoir, a first charged generator barrier separating the first eluent generator electrode chamber from the electrolyte ion reservoir, preventing liquid flow but permitting transport of said electrolyte ions, and a second generator electrode on the opposite side of the first generator barrier from the first generator electrode. Fluid flows from the ion receiving flow channel past the second generator electrode.Type: GrantFiled: July 7, 2000Date of Patent: May 13, 2003Assignee: Dionex CorporationInventors: Yan Liu, Nebojsa Avdalovic, Hamish Small
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Analytical assay device and methods using surfactant treated membranes to increase assay sensitivity
Patent number: 6558959Abstract: An analytical device comprising a surfactant-treated porous reaction membrane having an exposed sample-contacting surface and at least one receptor area located in a limited region of the exposed sample-contacting surface. The limited region has a higher concentration of surfactant than areas of the sample-contacting surface that are peripheral to the limited region. To make the device, a surfactant-containing solution comprising at least 0.2% surfactant is added to the reaction membrane and allowed to dry. Then, a receptor reagent is added to a limited region of the reaction membrane. In the assay, the surfactant causes the liquid sample to flow faster through the portion(s) of the reaction membrane where receptor molecules are located.Type: GrantFiled: July 11, 2001Date of Patent: May 6, 2003Inventor: Albert E. Chu -
Patent number: 6555003Abstract: A method for treating potato wastewater comprising the steps of pretreating a potato wastewater stream including suspended and dissolved solids with an alpha amylase enzyme to hydrolyze starch in the wastewater, ultra-filtering the enzyme-treated wastewater from step (a) to filter and remove a portion of the suspended solids in a first concentrate stream separated from the wastewater, and reverse osmosis-filtering the ultra-filtered wastewater from step (b) to remove at least about 70% of the wastewater dissolved and suspended solids in a second concentrate stream.Type: GrantFiled: January 19, 2001Date of Patent: April 29, 2003Assignee: Basic American, Inc.Inventors: Larry S. Ferro, Stephen C. O'Brien, Henry J. Camin, Bruce M. Wright
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Patent number: 6544767Abstract: The invention relates to cathepsin O2 proteins, nucleic acids, and antibodies.Type: GrantFiled: October 2, 1995Date of Patent: April 8, 2003Assignee: Axys Pharmaceuticals, Inc.Inventors: Dieter Brömme, Kathleen Okamoto
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Patent number: 6508985Abstract: An electrolyitic suppressor including (a) a suppressor bed of ion exchange resin, (b) an electrode chamber adjacent the suppressor, (c) a first electrode in the electrode chamber, (d) a barrier separating the suppressor bed from the first electrode chamber preventing significant liquid flow but permitting transport of ions only of the same charge as the suppressor bed resin, (e) a second electrode in electrical communication with the resin bed, and (f) a recycle conduit between the suppressor outlet port and said electrode chamber. The second electrode may be in contact with the ion exchange resin in the suppressor or located in second electrode chamber.Type: GrantFiled: June 8, 2001Date of Patent: January 21, 2003Assignee: Dionex CorporationInventors: Hamish Small, Yan Liu, John M. Riviello, Nebojsa Avdalovic, Kannan Srinivasan
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Patent number: 6495371Abstract: For anion analysis, the method includes: (a) flowing an aqueous liquid sample stream containing anions to be detected and cation hydroxide through a separator bed, (b) flowing the aqueous effluent from the separator bed through a flow-through suppressor, (c) flowing the effluent liquid from the suppressor past a detector, (d) recycling said liquid effluent from the detector through a cathode chamber proximate to the suppressor bed and separated by a first barrier, and (e) applying an electrical potential between the cathode and the anode. Water is electrolyzed at the anode to cause cations on the cation exchange resin to electromigrate toward the barrier and to be transported across the barrier toward the cathode while water in the cathode chamber is electrolyzed to generate hydroxide ions which combine with the transported cations to form cation hydroxide in the cathode chamber.Type: GrantFiled: June 8, 2001Date of Patent: December 17, 2002Assignee: Dionex CorporationInventors: Hamish Small, Yan Liu, John M. Riviello, Nebojsa Avdalovic, Kannan Srinivasan
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Patent number: 6485775Abstract: A starchy food-based fat mimetic suitable for use in smooth-textured products, and methods of making the fat mimetic are disclosed. In one method, potato granules are comminuted to fine particles so that at least 90% by weight of the fine potato particles have a particle size of less than about 50 microns. The potato granules can be comminuted by dispersing the potato granules in an aqueous liquid to form a slurry and homogenizing the slurry. The homogenized slurry can be used as a fat mimetic, or it can be dried to form a potato powder which can be added to food products as a fat mimetic. Also, mimetics made by the same process from other starch foods such as fresh potatoes, potato flakes, corn, wheat, rice or beans.Type: GrantFiled: October 15, 1999Date of Patent: November 26, 2002Assignee: Basic American, Inc.Inventors: Henry J. Camin, Lawrence G. Johnson, Rick C. Norton, Joel R. Tinsley, Richard A. Williams
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Patent number: 6472144Abstract: High-throughput screening method and apparatus are described. The method includes placing cells on a substrate defining a plurality of discrete microwells, at a well density of greater than about 100/cm2, with the number of cells in each well being less than about 1000, and where the cells in each well have been exposed to a selected agent. The change in conductance in each well is determined by applying a low-voltage, AC signal across a pair of electrodes paced in that well, and synchronously measuring the conductance across the electrodes, to monitor the level of growth or metabolic activity of cells contained in each well. Also disclosed is an apparatus for carrying out the screening method.Type: GrantFiled: March 20, 2001Date of Patent: October 29, 2002Assignee: Cellstat Technologies, Inc.Inventors: Patricia J. Malin, Kenneth R. Wada, Peter J. Dehlinger
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Patent number: 6468573Abstract: A method for making dehydrated, shelf-stable, puffed, rapidly-rehydratable, vegetable or fruit food pieces by puffing and drying moist food pieces (e.g. potato shreds) by conveying them in a bed through an impingement drying zone maintained at substantially atmospheric pressure in which streams of pressurized heated gas in a plurality of spaced fluid conduits exit from the conduits in spaced impinging streams at a velocity in excess of about 1,000 feet per minute are directed against the moist food pieces to cause the pieces to be suspended in a fluidized bed. In one case, the heated gas causes the moisture content of the moist food pieces to be reduced rapidly to puff them into porous pieces which exit the impingement drying zone having a moisture content of at least about 4% with a texture and appearance suitable for use as a rehydratable food piece.Type: GrantFiled: September 29, 2000Date of Patent: October 22, 2002Assignee: Basic American, Inc.Inventors: Marlin G. Herrick, J. Layne Anderson, Gary R. Eversoll, Kern L. Cooper, Ronald L. Luedeman, Gordon Ching
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Patent number: D494511Type: GrantFiled: March 11, 2002Date of Patent: August 17, 2004Inventor: Shun-Min Chen