Patents Represented by Attorney, Agent or Law Firm David J. Brezner
  • Patent number: 6808608
    Abstract: An apparatus for removing charged contaminants from a water stream. The apparatus can be figured to provide the decontaminated water stream to an analytical system. Methods of use of the same are also disclosed.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: October 26, 2004
    Assignee: Dionex Corporation
    Inventors: Kannan Srinivasan, Nebojsa Avdalovic
  • Patent number: 6752927
    Abstract: Method and apparatus for suppressed ion analysis in which a sample solution of analyte (e.g., anion) in an eluent of electrolyte counterions (e.g., sodium), is chromatographically separated. Then, the counterions are suppressed in a suppression zone and removed and used to convert the analyte ions to salt form in a salt-converting zone. The suppression and salt-converting zones may be contiguous or remote, and may be performed in devices of the membrane suppresser type. Thereafter, the salts or acids or bases formed from them (e.g., in membrane suppressor devices) are detected. Also, salt conversion can be performed using two ion exchange packed bed salt convertors in which one bed is on-line while the other is regenerated, followed by a reversal of flow.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: June 22, 2004
    Assignee: Dionex Corporation
    Inventors: Kannan Srinivasan, Sheetal Saini, Nebojsa Avdalovic
  • Patent number: 6750256
    Abstract: Methods and compositions based upon natural aromatic aldehydes are provided, which find use as pesticides. The pesticides are formulated in a variety of ways, including dusts, sprays, shampoos and soaps, and can be bound to a solid support or provided as bait or directly impregnated into organic matter infested by or susceptible to infestation by a target pest. Pests controlled include mosquitos, lice, ants, cockroaches, lice, and ticks.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: June 15, 2004
    Assignee: Proguard, Inc.
    Inventors: Bradford G. Crandall, Jr., Ralph W. Emerson
  • Patent number: 6747135
    Abstract: The present invention is directed to novel polypeptides, termed fluorettes, that bind with high avidity to fluorophore dyes. The peptides find use in a variety of methods and approaches involving fluorophore dyes.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: June 8, 2004
    Assignee: The Board of Trustees for the Leland Stanford Junior University
    Inventors: Garry P. Nolan, Michael N. Rozinov
  • Patent number: 6742278
    Abstract: The present invention relates to the treatment of wood, and is particularly concerned with a method for increasing the permeability of wood, especially moist wood.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: June 1, 2004
    Assignee: The University Of Melbourne
    Inventors: Peter Vinden, Francisco Javier Romero, Grigory Torgovnikov
  • Patent number: 6682701
    Abstract: Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: January 27, 2004
    Assignee: Dionex Corporation
    Inventors: Yan Liu, Hamish Small, Nebojsa Avdalovic
  • Patent number: 6645378
    Abstract: A modified silica support having a polar phase bound to its surface and suitable for use for chromatographic separations, having the following formula: wherein, m=0-20; n=0-20; p=1-50; X is sulfonyl, carbonyl, carbamoyl, or oxycarbonyl; R1=H, alkyl, substituted alkyl, aryl or substituted aryl groups; R2=alkyl, substituted alkyl, aryl or substituted aryl groups; and R3 and R4 are alkyl, aryl, hydroxyl, or alkoxyl groups or groups including oxygen atoms cross-linked to silicon atoms. Also, a polar silane intermediate to make this support.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: November 11, 2003
    Assignee: Dionex Corporation
    Inventors: Xiaodong Liu, Andrei V. Bordunov
  • Patent number: 6632681
    Abstract: A device and method for filtering a biologically derived sample and for mixing the sample with a reagent, comprising a fluid container defining a reservoir compartment and including a container outlet, a filter and a fluid flow-through matrix disposed in a flow path between the reservoir compartment and the container outlet. Water-soluble, dried reagent is retained on the matrix. Means is provided for urging sample in an aqueous liquid in the reservoir compartment through the filter and matrix and out the container outlet. Pressure is applied to the sample in an aqueous liquid in the reservoir compartment to cause the sample to flow in liquid through the filter and matrix and out of the container for analysis.
    Type: Grant
    Filed: July 24, 2000
    Date of Patent: October 14, 2003
    Assignee: EY Laboratories
    Inventor: Albert E. Chu
  • Patent number: 6610546
    Abstract: An electrolytic suppressor including (a) packing (a suppressor bed of ion exchange resin or a flow-through monolith), (b) an electrode chamber adjacent the suppressor, (c) a first electrode in the electrode chamber, (d) a barrier separating the packing from the first electrode chamber preventing significant liquid flow but permitting transport of ions only of the same charge as the packing, (e) a second electrode in electrical communication with the resin bed, and (f) a recycle conduit between the suppressor outlet port and said electrode chamber. Charged transverse partitions with openings may be included to create a serpentine liquid path.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: August 26, 2003
    Assignee: Dionex Corporation
    Inventors: Yan Liu, Kannan Srinivasan, Nebojsa Avdalovic, Hamish Small, John M. Riviello
  • Patent number: 6596975
    Abstract: A method for increasing the permeability of wood which comprises subjecting wood with a moisture content (based on dry weight) of at least 15% to microwave radiation at a frequency (f) in the range of from about 0.1 to about 24 GHz with a power intensity (p) from about 10 W/cm2 to about 100 kW/cm2 for a duration of from about 0.05 to about 600 seconds to cause water in the wood to vaporise resulting in an internal pressure in the wood such that the permeability of the wood is increased by partial or complete destruction of ray cell tissue, softening and displacement of wood resin, formation of pathways in the radial direction of the wood and/or by creating, on the base of destroyed rays, cavities in the wood, said cavities being primarily in radial-longitudinal planes of the wood, and wherein the overall integrity of the wood is substantially maintained. A wood-based material may be formed having a permeability which is at least 5 times that of the untreated wood.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: July 22, 2003
    Assignee: The University of Melbourne
    Inventors: Peter Vinden, Francisco Javier Romero, Grigory Torgovnikov
  • Patent number: 6562628
    Abstract: A combination electrolytic suppressor and separate eluent generator and method. The suppressor includes a chromatography effluent flow channel, an ion receiving flow channel, and a first suppressor ion exchange barrier therebetween permeable to electrolyte ions but not liquid flow. The effluent from the chromatography effluent compartment flows through the detector, the ion receiving channel, and to an eluent generator. The generator includes a first generator electrode in a first generator electrode chamber, an electrolyte ion reservoir, a first charged generator barrier separating the first eluent generator electrode chamber from the electrolyte ion reservoir, preventing liquid flow but permitting transport of said electrolyte ions, and a second generator electrode on the opposite side of the first generator barrier from the first generator electrode. Fluid flows from the ion receiving flow channel past the second generator electrode.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: May 13, 2003
    Assignee: Dionex Corporation
    Inventors: Yan Liu, Nebojsa Avdalovic, Hamish Small
  • Patent number: 6558959
    Abstract: An analytical device comprising a surfactant-treated porous reaction membrane having an exposed sample-contacting surface and at least one receptor area located in a limited region of the exposed sample-contacting surface. The limited region has a higher concentration of surfactant than areas of the sample-contacting surface that are peripheral to the limited region. To make the device, a surfactant-containing solution comprising at least 0.2% surfactant is added to the reaction membrane and allowed to dry. Then, a receptor reagent is added to a limited region of the reaction membrane. In the assay, the surfactant causes the liquid sample to flow faster through the portion(s) of the reaction membrane where receptor molecules are located.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: May 6, 2003
    Inventor: Albert E. Chu
  • Patent number: 6555003
    Abstract: A method for treating potato wastewater comprising the steps of pretreating a potato wastewater stream including suspended and dissolved solids with an alpha amylase enzyme to hydrolyze starch in the wastewater, ultra-filtering the enzyme-treated wastewater from step (a) to filter and remove a portion of the suspended solids in a first concentrate stream separated from the wastewater, and reverse osmosis-filtering the ultra-filtered wastewater from step (b) to remove at least about 70% of the wastewater dissolved and suspended solids in a second concentrate stream.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: April 29, 2003
    Assignee: Basic American, Inc.
    Inventors: Larry S. Ferro, Stephen C. O'Brien, Henry J. Camin, Bruce M. Wright
  • Patent number: 6544767
    Abstract: The invention relates to cathepsin O2 proteins, nucleic acids, and antibodies.
    Type: Grant
    Filed: October 2, 1995
    Date of Patent: April 8, 2003
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: Dieter Brömme, Kathleen Okamoto
  • Patent number: 6508985
    Abstract: An electrolyitic suppressor including (a) a suppressor bed of ion exchange resin, (b) an electrode chamber adjacent the suppressor, (c) a first electrode in the electrode chamber, (d) a barrier separating the suppressor bed from the first electrode chamber preventing significant liquid flow but permitting transport of ions only of the same charge as the suppressor bed resin, (e) a second electrode in electrical communication with the resin bed, and (f) a recycle conduit between the suppressor outlet port and said electrode chamber. The second electrode may be in contact with the ion exchange resin in the suppressor or located in second electrode chamber.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: January 21, 2003
    Assignee: Dionex Corporation
    Inventors: Hamish Small, Yan Liu, John M. Riviello, Nebojsa Avdalovic, Kannan Srinivasan
  • Patent number: 6495371
    Abstract: For anion analysis, the method includes: (a) flowing an aqueous liquid sample stream containing anions to be detected and cation hydroxide through a separator bed, (b) flowing the aqueous effluent from the separator bed through a flow-through suppressor, (c) flowing the effluent liquid from the suppressor past a detector, (d) recycling said liquid effluent from the detector through a cathode chamber proximate to the suppressor bed and separated by a first barrier, and (e) applying an electrical potential between the cathode and the anode. Water is electrolyzed at the anode to cause cations on the cation exchange resin to electromigrate toward the barrier and to be transported across the barrier toward the cathode while water in the cathode chamber is electrolyzed to generate hydroxide ions which combine with the transported cations to form cation hydroxide in the cathode chamber.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: December 17, 2002
    Assignee: Dionex Corporation
    Inventors: Hamish Small, Yan Liu, John M. Riviello, Nebojsa Avdalovic, Kannan Srinivasan
  • Patent number: 6485775
    Abstract: A starchy food-based fat mimetic suitable for use in smooth-textured products, and methods of making the fat mimetic are disclosed. In one method, potato granules are comminuted to fine particles so that at least 90% by weight of the fine potato particles have a particle size of less than about 50 microns. The potato granules can be comminuted by dispersing the potato granules in an aqueous liquid to form a slurry and homogenizing the slurry. The homogenized slurry can be used as a fat mimetic, or it can be dried to form a potato powder which can be added to food products as a fat mimetic. Also, mimetics made by the same process from other starch foods such as fresh potatoes, potato flakes, corn, wheat, rice or beans.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: November 26, 2002
    Assignee: Basic American, Inc.
    Inventors: Henry J. Camin, Lawrence G. Johnson, Rick C. Norton, Joel R. Tinsley, Richard A. Williams
  • Patent number: 6472144
    Abstract: High-throughput screening method and apparatus are described. The method includes placing cells on a substrate defining a plurality of discrete microwells, at a well density of greater than about 100/cm2, with the number of cells in each well being less than about 1000, and where the cells in each well have been exposed to a selected agent. The change in conductance in each well is determined by applying a low-voltage, AC signal across a pair of electrodes paced in that well, and synchronously measuring the conductance across the electrodes, to monitor the level of growth or metabolic activity of cells contained in each well. Also disclosed is an apparatus for carrying out the screening method.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: October 29, 2002
    Assignee: Cellstat Technologies, Inc.
    Inventors: Patricia J. Malin, Kenneth R. Wada, Peter J. Dehlinger
  • Patent number: 6468573
    Abstract: A method for making dehydrated, shelf-stable, puffed, rapidly-rehydratable, vegetable or fruit food pieces by puffing and drying moist food pieces (e.g. potato shreds) by conveying them in a bed through an impingement drying zone maintained at substantially atmospheric pressure in which streams of pressurized heated gas in a plurality of spaced fluid conduits exit from the conduits in spaced impinging streams at a velocity in excess of about 1,000 feet per minute are directed against the moist food pieces to cause the pieces to be suspended in a fluidized bed. In one case, the heated gas causes the moisture content of the moist food pieces to be reduced rapidly to puff them into porous pieces which exit the impingement drying zone having a moisture content of at least about 4% with a texture and appearance suitable for use as a rehydratable food piece.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: October 22, 2002
    Assignee: Basic American, Inc.
    Inventors: Marlin G. Herrick, J. Layne Anderson, Gary R. Eversoll, Kern L. Cooper, Ronald L. Luedeman, Gordon Ching
  • Patent number: D494511
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: August 17, 2004
    Inventor: Shun-Min Chen