Abstract: The present invention relates to a compound of the formula 1 wherein R1-R4 are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
Type:
Grant
Filed:
August 17, 2006
Date of Patent:
April 1, 2008
Assignee:
Pfizer Inc
Inventors:
John Charles Kath, Michael Joseph Luzzio