Patents Represented by Attorney, Agent or Law Firm David L. Marks
  • Patent number: 7153814
    Abstract: The invention relates to compounds of the general formula (I), in which Ar, R1, R2, R3, R4, R5, R6, R7, R8, W, a, b and n are as defined in claim 1, and to any enantiomers thereof. The active ingredients have advantageous pesticidal properties.
    Type: Grant
    Filed: January 20, 2003
    Date of Patent: December 26, 2006
    Assignee: Novartis Animal Health US, Inc.
    Inventors: Pierre Ducray, Thomas Goebel, Jorg Fruchtel, Jacques Bouvier
  • Patent number: 7148255
    Abstract: The invention relates to compounds of formula I wherein R1, R2, R3, R4, R5, R6, R8, R8?, R9, W, X, A1, A2, a, b and c have the significances given in the specification, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: December 12, 2006
    Assignee: Novartis Animal Health US, Inc.
    Inventors: Pierre Ducray, Thomas Goebel, Jacques Bouvier, Corinne Durano
  • Patent number: 7128917
    Abstract: The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus. Specifically, such vaccines contain at least one nucleic acid sequence which is derived from ISAV or synthetically prepared analogues thereof, or substantially homologous sequences. These nucleic acid sequences are transcripted and translated into peptide sequences which are incorporated into a vaccination strategy to induce and immune response to the surface antigens of ISAV and therefore ISAV itself. Therefore both the use of a vaccine against ISAV, and the incorporation of peptide sequences is herein described.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: October 31, 2006
    Assignees: Novartis, AG, Ottawa Health Research Institute
    Inventors: Steven Griffiths, Rachael Jane Ritchie, Joel Heppell
  • Patent number: 7091371
    Abstract: The invention relates to compounds of the general formula (I), in which R1, R2, X, Ar1 and Ar2 are as defined in claim 1, and to any enantiomers thereof. The active ingredients have advantageous pesticidal properties.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: August 15, 2006
    Assignee: Novartis Animal Health US, Inc.
    Inventors: Pierre Ducray, Thomas Goebel
  • Patent number: 7084280
    Abstract: The invention relates to benzotriazol-1-yl-aminoacetonitrile compounds and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: August 1, 2006
    Inventors: Pierre Ducray, Thomas Goebel, Noelle Gauvry
  • Patent number: 7063856
    Abstract: The invention relates to a composition for controlling a pest, including endoparasites, and more specifically helminths, of formula (I) in animals, and methods related to thereof.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: June 20, 2006
    Assignee: Novartis Animal Health US, Inc.
    Inventors: Pierre Ducray, Jacques Bouvier
  • Patent number: 7052707
    Abstract: The invention relates to a composition for controlling a pest, including endoparasites, and more specifically helminths, of formula (I) in animals, and methods related to thereof.
    Type: Grant
    Filed: January 21, 2002
    Date of Patent: May 30, 2006
    Assignee: Novartis Animal Health US, Inc.
    Inventors: Pierre Ducray, Jacques Bouvier
  • Patent number: 6974577
    Abstract: Inactivated scours vaccines for immunization and protection of bovine animals from disease caused by infection with bovine rotavirus and bovine coronavirus, which comprise and effective amount of at least one inactivated viral strain are described. Polyvalent inactivated vaccines further comprising an effective amount of an antigenic component which is protective against one or more additional pathogenic organisms or viruses are also disclosed. Said vaccines are prepared from one or more strains of rota- and coronavirus, C. perfringens Type C bacteria and E. coli bacteria, and combinations thereof. Preferably, a polyvalent inactivated vaccine is provided for parenteral administration. Passive immunity is achieved in neonatal calves via immunization of pregnant cows prior to birth.
    Type: Grant
    Filed: February 4, 2001
    Date of Patent: December 13, 2005
    Assignee: Novartris AG
    Inventors: Kelly Knape, Stephanie Dykstra, Mary Tinant
  • Patent number: 6919083
    Abstract: The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus. Specifically, such vaccines contain at least one nucleic acid sequence which is derived from ISAV or synthetically prepared analogues thereof, or substantially homologous sequences. These nucleic acid sequences are transcripted and translated into peptide sequences which are incorporated into a vaccination strategy to induce an immune response to the surface antigens of ISAV and therefore ISAV itself. Therefore both the use of a vaccine against ISAV, and the incorporation of peptide sequences, is herein described.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: July 19, 2005
    Assignees: Novartis AG, Ottawa Health Research Institute
    Inventors: Steven Griffiths, Rachel Jane Ritchie, Joel Heppell
  • Patent number: 6913754
    Abstract: The invention provides and immune stimulating agent or vaccine directed to Renibacterium salmoninarum comprising a live non-virulent culture of an Arthrobacter strain based on, derived from or substantially homologous with strain RSxII as deposited as ATCC 55921. The culture may be presented in lyophilized form with a sterile diluent.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: July 5, 2005
    Assignee: Novartis AG
    Inventors: Steven Gareth Griffiths, Kira Salonius
  • Patent number: 6887989
    Abstract: The present invention relates to a fish vaccine. More specifically the invention relates to a vaccine to protect salmon against infection by Piscirickettsia salmonis. The invention is based on or derived from the nucleic acid or amino acid sequence of antigens from Piscirickettsia salmonis. Nucleic acid and/or amino acid sequences may be used in the preparation of a vaccine to protect against infection by Piscirickettsia salmonis.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: May 3, 2005
    Assignee: Novartis AG
    Inventors: Nathalie Simard, Huub Brouwers, Simon Jones, Steve Griffiths, Pablo Valenzuela, Luis Burzio
  • Patent number: 6780876
    Abstract: The invention describes essentially a non-therapeutical process for deterring vermin, which is based on the usage of the largely known compounds of formula (I), as defined herein before. Furthermore, it describes the corresponding vermin-deterring compositions which contain these substances as the active ingredient, compounds of formula (I) for the preparation of vermin-deterring compositions, and the use of compounds of formula (I) in the defence against vermin. Thus, the invention describes how and in which form the compounds of formula (I) or their acid addition salts are used to deter vermin from materials, places or warm-blooded animals.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: August 24, 2004
    Assignee: Novartis Animal Health US, Inc.
    Inventors: Olivier Froelich, Jacques Bouvier, Catherine Christinaz, Nicola Di Criscio
  • Patent number: 6759407
    Abstract: Novel pesticides of formula (I) wherein the substituents, R, R1, R2, R2′, T, U, X and Y are as defined in claim 1, are described. Also described are compositions suitable for use as parasiticides comprising those compounds as active ingredient and to methods of controlling parasites that are based on the administration of those compounds or compositions, and to the use of the said compounds and compositions in a method of controlling parasites and in the manufacture of pesticides for use against parasites. Also described are intermediates of formula (XX) wherein R1, R2, R2′, T, U, X and Y are as defined in claim 1; and Hal is halogen. The latter also exhibit parasiticidal activity and are suitable for the preparation of the compounds of formula (I).
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: July 6, 2004
    Assignee: Novartis Animal Health US, Inc.
    Inventors: Thomas Goebel, Eliane Humbert-Droz, Maurizio Schwarzenbach
  • Patent number: 6660379
    Abstract: The steady state and time resolved luminescence spectral properties of two types of novel CdS nanoparticles and nanoparticles are described. CdS nanoparticles formed in the presence of an amine-terminated dendrimer show blue emission. The emission wavelength of these nanoparticles depended on the excitation wavelength. The CdS/dendrimer nanoparticles display polarized emission with the anisotropy rising progressively from 340 to 420 nm excitation, reaching a maximal anisotropy value in excess of 0.3. A new constant positive polarized emission from luminescent nanoparticles is also described. Polyphosphate-stabilized CdS nanoparticles are described that display a longer wavelength red emission maximum than bulk CdS and display a zero anisotropy for all excitation wavelengths. Both nanoparticles display strongly heterogeneous intensity decays with mean decay times of 93 ns and 10 &mgr;s for the blue and red emitting particles, respectively.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: December 9, 2003
    Assignee: University of Maryland, Baltimore
    Inventors: Joseph R. Lakowicz, Ignacy Gryczynski, Zygmunt Gryczynski
  • Patent number: 6635259
    Abstract: Several EHEC proteins which are secreted into the culture supernatant have been discovered. These proteins are not produced by non-pathogenic E. coli, and produce a strong serum antibody response in patients with HUS and bloody diarrhea.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: October 21, 2003
    Assignee: University of Maryland, Baltimore
    Inventors: James B. Kaper, Karen Jarvis
  • Patent number: 6632439
    Abstract: The present invention relates to a method of producing a vaccine for the prevention of F. necrophorum bacterial infections, comprising isolating the F. necrophorum bacteria from a bovine species, growing the bacteria in a suitable growth medium for a period equal to between about 10 hours and about 18 hours so as to achieve a bacterial population equal to at least 1×105 CFU/ml, terminating the growth, and using a whole cell culture to form the vaccine. Additionally, the present invention relates to the vaccine comprised of a killed whole cell population of the F. necrophorum bacteria taken from a bovine. The present invention further relates to a method for preventing footrot and liver abscesses caused by F. necrophorum bacteria.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: October 14, 2003
    Assignee: Novartis Animal Health, Inc.
    Inventors: Adrian Liem, Gary A. Anderson, Douglas L. Stine
  • Patent number: 6627203
    Abstract: The invention provides an immune stimulating agent or vaccine directed to Renibacterium salmoninarum comprising a live non-virulent culture of an Arthrobacter strain based on, derived from or substantially homologous with strain RSxII as deposited as ATCC 55921. The culture may be presented in lyophilized form with a sterile diluent.
    Type: Grant
    Filed: April 5, 2000
    Date of Patent: September 30, 2003
    Assignee: Aqua Health (Europe) Limited
    Inventors: Steven Gareth Griffiths, Kira Salonius
  • Patent number: 6204004
    Abstract: Several EHEC proteins which are secreted into the culture supernatant have been discovered. These proteins are not produced by non-pathogenic E. coli, and produce a strong serum antibody response in patients with HUS and bloody diarrhea.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: March 20, 2001
    Assignee: University of Maryland, Baltimore
    Inventors: James B. Kaper, Karen Jarvis
  • Patent number: 6203896
    Abstract: An image transfer sheet and method is provided for transferring an image of the original to a hard target body made of metal, glass, ceramics, plastics, or similar materials. The image transfer sheet has a support base and a synthetic resin layer detachably bound thereon, preferably a water-soluble resin layer in between. The synthetic resin layer has a thickness in the range of 10 to 500 &mgr;m, and preferably includes a first layer that is adhesive to the hard target body, and a second layer that is fixedly receivable active toner of electrostatic process copying machine or printers. First, by means of an electrostatic process copying machine or electrostatic printer, an image is transferred to the synthetic resin layer of the image transfer sheet, which is then released from the support base and applied to the target body. Consequently, the target body which now has the image transfer layer thereon is dried or heated to fixate the image transfer layer.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: March 20, 2001
    Assignee: Maryland China Company
    Inventor: Hiroyasu Nomura
  • Patent number: 6197258
    Abstract: The invention described in detail herein relates to the detection, determination, and quantitation of certain ions and small molecules in solution. The invention specifically relates to improvements in the area of photoluminescent sensors for use in a detection scheme involving the alteration of a photoluminescent label or moiety attached to or associated with an analyte binding macromolecule. One may use the changes in photoluminescence lifetime, changes in ratios of photoluminescence intensity or changes in photoluminescence polarization (anisotropy) to determine the analyte. The photoluminescence change measured correlates to the concentration of the ion or molecule in solution.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: March 6, 2001
    Assignee: University of Maryland, Baltimore
    Inventors: Richard B. Thompson, Vincent L. Feliccia, Badri P. Maliwal, Carol A. Fierke