Abstract: Disclosed are topical compositions for regulating the oily and/or shiny appearance of skin. The compositions contain:(a) an active for regulating the oily and/or shiny appearance of skin, said active consisting essentially of one or more compounds selected from the group consisting of niacinamide, pyridoxine, panthenol, and pantothenic acid, in an amount that is safe and effective for regulating the oily and/or shiny appearance of the skin; and(b) a cosmetically acceptable carrier for said active. Also disclosed are methods of regulating the oily and/or shiny appearance of skin by topical application of such compositions.

Abstract: The invention provides compounds which are useful as inhibitors of matrix metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I) ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are described in the claims, a stereoisomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable alkoxyamide, ester acyloxyamide, imide or derivative thereof.Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by matrix metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

Abstract: The present invention relates to compositions which are useful for providing protection to the skin of humans from the harmful effects of ultraviolet radiation. In particular the present invention relates to compositions having improved chemical, physical, and photostability. These compositions comprise from about 0.1% to about 10% of a dibenzoylmethane sunscreen compound, from about 0.1% to about 20% of a surface-treated zinc oxide, and a carrier suitable for application to the skin.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;(b) X is selected from the group consisiting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; and(e) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: The subject invention relates to compositions which are useful for improving the visual appearance of skin, especially facial skin. The composition contains certain primary actives including at least one cyclic polyanionic polyols at least one sulfhydryl compound and at least one zwitterionic surfactant. The subject invention further relates to methods of improving the visual appearance of skin.

Abstract: The present invention relates to a process for separating polyhydroxyalkanoate (PHA) from a biomass comprising the PHA, the process comprising: a) treating the biomass with a PHA solvent and a marginal nonsolvent for PHA; b) removing any insoluble biomass, thereby leaving behind a solution of PHA and marginal nonsolvent for PHA; and c) removing the PHA solvent from the solution, thereby resulting in a suspension of precipitated PHA in the marginal nonsolvent for PHA. Optionally, the process further comprises removing the marginal nonsolvent for PHA, thereby leaving behind the PHA. The present invention further relates to the suspension and the PHA produced by the process.

Abstract: The present invention is for a process for preparing monoacetals of hydroquinone wherein said process provides for higher yields of greater purity. Said process utilizes a two step reaction wherein a protected hydroquinone is reacted with an enol ether to form a protected intermediate. Upon hydrogenolysis of said intermediate a final product, monoacetal hydroquinone, is formed having higher degree of purity and in greater yields that the yields attributed to reactions known in the art.

Abstract: The subject invention relates to compounds having the structure: ##STR1## as defined in the claims, and to pharmaceutical compositions containing such compounds, and the use of such compounds for preventing or treating of disorders modulated by alpha-2 adrenoceptors.

Abstract: The present invention provides processes for making compounds of the structure(Q--L.sup.1)--L--(L.sup.2 --B)wherein(I) Q is a quinolone moiety;(II) B is a lactam moiety; and(III) L, L.sup.1, and L.sup.2 together comprise a linking moiety;comprising the steps of:(1) coupling a compound of Formula (III) with a lactam-containing compound to form an intermediate compound; and(2) cyclizing the intermediate by reaction with an organosilicon compound to give a compound of the formula (Q--L.sup.1)--L--(L.sup.2 --B).Preferably, the process additionally comprises a step prior to the coupling step, wherein protected forms of the compound of Formula (III) and the lactam compound are formed; and deprotection steps after the cyclization step, wherein the protecting groups are removed. Preferred antimicrobial compounds made by these processes are those where the beta-lactam moiety is a penem, a carbapenem, a cephem, or a carbacephem. Also preferred are those compounds where L.sup.1, L, and L.sup.

Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.

Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.

Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.

Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.

Abstract: The present invention comprises processes for preparing biodegradable fibrils from one or more biodegradable homopolymeric or copolymeric resins, said process comprising: a) forming a liquid resin mixture by melting or solvating the resin or resins; and b) introducing the liquid resin mixture to a flow of a gaseous substance. The present invention further comprises biodegradable fibrils made according to the processes of the present invention. The invention further comprises nonwoven fabrics comprising biodegradable fibrils. The invention further comprises disposable absorbent articles comprising a water-permeable topsheet, an absorbent core, and a water-impermeable backsheet, wherein the topsheet comprises a nonwoven substrate comprising biodegradable fibrils. The invention further comprises disposable articles comprising biodegradable fibrils.

Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.

Abstract: The present invention relates to compositions comprising pharnaceutically-acceptable carriers and a phosphonocarboxylate, or a pharmaceutically-acceptable salt thereof, having a structure according to formula (I): ##STR1##

Abstract: The subject invention involves anti-inflammatory compounds having the following structure: ##STR1## wherein: a) --X is cyclic alkyl, having from 4 to 15 carbon atoms; branched alkyl, having from 6 to 15 carbon atoms; or aryl having from 6 to 15 carbon atoms;(b) n is an integer from 0 to 2;(c) --V-- is --OC(O)--, --N(Q)C(O)--, --N(Q)C(S)--, --C(O)--, --SO2-- or --P(O)(OH)--;(d) --Q is hydrogen; or straight or branched chain alkyl, saturated or unsaturated with 1 or 2 double bonds, having from 1 to 6 carbon atoms; or --Q and --X are covalently linked forming a cyclic moiety which includes the nitrogen to which --Q is bonded and from 5 to 20 carbon atoms;(e) Z is --O-- or --NH--; when V is --OC(O)--, --Z-- is --NH--;(f) --R1 is a hydrophobic moiety;(g) --R2 is a hydrophobic moiety;(h) --R3 is --(CH2)m--A--NH2 or --(CH2)m--A--B--C(NH2).dbd.

Abstract: Disclosed are aqueous conditioning shampoo compositions which comprise an anionic detersive surfactant component; dispersed, liquid, droplets of a water insoluble, hair conditioning agent having a number average particle diameter of from about 0.01 microns to about 2000 microns; from about 0.025% to about 5% by weight of an organic, cationic, non crosslinked, deposition or conditioning polymer having a cationic charge density of from about 4 meq/gm to about 7 meq/gm and an average molecular weight of from about 1,000 to about 1 million. The cationic polymer, in combination with anionic detersive surfactant component and other essential components, provides improved deposition of the conditioning agent on hair or skin, even when the dispersed conditioning agent particles have a number average particle size of up to about 2,000 microns. The composition may be applied to skin or hair, and provides improved conditioning performance even without the use of the dispersed hair conditioning agent particles.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen;(e) W is O or S; and(f) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: Disclosed are anhydrous antiperspirant gel-solid stick compositions which comprise a particulate antiperspirant active; a solid non-polymeric gellant selected from the group consisting of 12-hydroxystearic acid, esters of 12-hydroxystearic acid, amides of 12-hydroxystearic acid, and combinations thereof, and an anhydrous liquid carrier having an average solubility parameter of from about 3 to about 13 (cal/cm.sup.3).sup.0.5, wherein the composition has a visible residue index of from about 11 to about 30 L-value, a product hardness of from about 500 gram.force to about 5,000 gram.force, a ratio of an elastic to viscous moduli of from about 0.1 to about 100. The refractive indices of the particulate antiperspirant active, solid non-polymeric gellant, and anhydrous liquid carrier are not matched. The solid non-polymeric gellant is preferably a crystalline material having an average particle size of less than about 1 .mu.