Patents Represented by Attorney David M. Morse

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  • BU-3862T antitumor antibiotic
    Patent number: 5093248
    Abstract: A new antitumor antibiotic designated herein as BU-3862T is produced by fermentation of Streptomyces hygroscopicus ATCC 53709. BU-3862T and its diacetyl and dihydro derivatives inhibit the growth of tumors in experimental animals.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: March 3, 1992
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Koko Sugawara, Masami Hatori, Hideo Kamei, Masataka Konishi, Toshikazu Oki, Koji Tomita
  • Antitumor antibiotic BU-3285T
    Patent number: 5089522
    Abstract: The present invention relates to the antitumor antibiotic compound BU-3285T and its preparation. The compound is obtained by culturing a new strain of Chainia rosea and demonstrates both antitumor and antifungal activity. It also relates to the desulfated derivative of BU-3285T which is obtained by treatment of BU-3285T with sulfatase enzyme. BU-3285T desulfate possesses antitumor activity.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: February 18, 1992
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Hiroaki Ohkuma, Koji Tomita, Masataka Konishi, Hideo Kamei
  • Antitumor antibiotic BMY-42428
    Patent number: 5087567
    Abstract: An antitumor antibiotic designated BMY-42428 is produced by fermentation of Actinomadura madurae ATCC-53806. The BMY-42428 antibiotic exhibits both antimicrobial and antitumor activities.
    Type: Grant
    Filed: January 12, 1990
    Date of Patent: February 11, 1992
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas T. Dabrah, Grace A. Hesler, Sandra J. Hofstead, Kin S. Lam, Jacqueline M. Mattei, Daniel R. Schroeder, Koji Tomita
  • Antitumor antibiotic
    Patent number: 5086045
    Abstract: An antitumor antibiotic designated BMY-41339 is produced by fermentation of certain strains of Actinomadura verrucosospora. BMY-41339 exhibits antimicrobial activity and also inhibits the growth of tumors in experimental animals.
    Type: Grant
    Filed: August 24, 1990
    Date of Patent: February 4, 1992
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, John Beutler, Pat Clark, John Ross, John Roach, Gary Muschik, William B. Lebherz, III
  • Peptide antibiotics
    Patent number: 5079148
    Abstract: Novel peptides of the formula ##STR1## wherein R is CH.sub.3 --(CH.sub.2).sub.6, CH.sub.3 --(CH.sub.2).sub.4 --CH.dbd.CH--(CH.sub.2).sub.2 and CH.sub.3 (CH.sub.2).sub.8 having antibiotic and antitumor activity are prepared by cultivation of the novel microorganism Polyangium brachysporum. Enzymatic hydrolysis of those peptides gives other peptides useful as intermediates in the preparation of peptides having activity as antibiotics and/or antitumor agents.
    Type: Grant
    Filed: September 7, 1990
    Date of Patent: January 7, 1992
    Assignee: Bristol-Myers Squibb Company
    Inventors: Masataka Konishi, Koji Tomita, Masahisa Oka, Ken-ichi Numata
  • BMY-41950 antitumor antibiotic
    Patent number: 5073633
    Abstract: An antitumor antibiotic designated BMY-41950 is produced by fermentation of Streptomyces staurosporeus ATCC 55006 or Streptomyces hygroscopicus ATCC 53730. The BMY-41950 antibiotic exhibits both antimicrobial and antitumor activities.
    Type: Grant
    Filed: November 5, 1990
    Date of Patent: December 17, 1991
    Assignee: Bristol-Myers Company
    Inventors: Daniel Schroeder, Kin S. Lam, Jacqueline Mattei, Grace A. Hesler
  • BU-4146T antibiotic
    Patent number: 5037836
    Abstract: A novel antibiotic designated BU-4146T is produced by fermentation of Streptomyces amphibiosporus strain R310-104 (ATCC-53964). The antibiotic possesses both antifungal and antitumor activity.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: August 6, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Masataka Konishi, Koko Sugawara, Masaru Ohbayashi, Takeo Miyaki
  • BMY-40800 antitumor antibiotics
    Patent number: 5036010
    Abstract: A new antitumor antibiotic designated BMY-40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.
    Type: Grant
    Filed: April 26, 1990
    Date of Patent: July 30, 1991
    Assignee: Bristol-Myers Company
    Inventors: King S. Lam, Jacqueline Mattei, John E. Leet, James A. Matson, Koji Tomita, Murray A. Kaplan
  • Antitumor antibiotic BU-3285T
    Patent number: 5036008
    Abstract: The present invention relates to the antitumor antibiotic compound BU-3285T and its preparation. The compound is obtained by culturing a new strain of Chainia rosea and demonstrates both antitumor and antifungal activity. It also relates to the desulfated derivative of BU-3285T which is obtained by treatment of BU-3285T with sulfatase enzyme. BU-3285T desulfate possesses antitumor activity.
    Type: Grant
    Filed: April 11, 1990
    Date of Patent: July 30, 1991
    Assignee: Bristol-Myers Company
    Inventors: Hiroaki Ohkuma, Koji Tomita, Masataka Konishi, Hideo Kamei
  • Antitumor antibiotic BMY-41339
    Patent number: 5028536
    Abstract: An antitumor antibiotic designated BMY-41339 is produced by fermentation of certain strains of Actinomadura verrucosospora. BMY-41339 exhibits antimicrobial activity and also inhibits the growth of tumors in experimental animals.
    Type: Grant
    Filed: March 15, 1989
    Date of Patent: July 2, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, John Beutler, Pat Clark, John Ross, John Roach, Gary Muschik, William B. Lebherz, III
  • Peptide antibiotics
    Patent number: 5025023
    Abstract: Novel peptides of the formula ##STR1## wherein R is CH.sub.3 --(CH.sub.2).sub.6, CH.sub.3 --(CH.sub.2).sub.4 --CH.dbd.CH--(CH.sub.2).sub.2 and CH.sub.3 (CH.sub.2).sub.8 having antibiotic and antitumor activity are prepared by cultivation of the novel microorganism Polyangium brachysporum. Enzymatic hydrolysis of those peptides gives other peptides useful as intermediates in the preparation of peptides having activity as antibiotics and/or antitumor agents.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: June 18, 1991
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Koji Tomita, Masahisa Oka, Ken-ichi Numata
  • BMY-41950 antitumor antibiotic
    Patent number: 5015578
    Abstract: A new antitumor antibiotic designated BMY-41950 is produced by fermentation of Streptomyces staurosporeus ATCC 55006 or Streptomyces hygroscopicus ATCC 53730. The BMY-41950 antibiotic exhibits both antimicrobial and antitumor activities.
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: May 14, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Daniel Schroeder, Kin S. Lam, Jacqueline Mattei, Grace A. Hesler
  • BU-4146T antibiotic
    Patent number: 5002959
    Abstract: A novel antibiotic designated BU-4146T is produced by fermentation of Streptomyces amphibiosporus strain R310-104 (ATCC-53964). The antibiotic possesses both antifungal and antitumor activity.
    Type: Grant
    Filed: December 11, 1989
    Date of Patent: March 26, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Masataka Konishi, Koko Sugawara, Masaru Ohbayashi, Takeo Miyaki
  • BU-3839T antibiotic
    Patent number: 5001058
    Abstract: A new antibiotic having the chromophore structure of the plurmycin family of antibiotics is produced by fermentation of Streptomyces violaceus ATCC 53807. The new antibiotic designated BU-3839T, exhibits potent antibacterial activity and also inhibits the growth of tumors in experimental animal systems.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: March 19, 1991
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Keiko Shimizu, Masaru Ohbayashi, Koji Tomita, Takeo Miyaki, Toshikazu Oki
  • BMY-40800 antitumor antibiotics
    Patent number: 4994271
    Abstract: A new antitumor antibiotic designated BMY-40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.
    Type: Grant
    Filed: February 16, 1988
    Date of Patent: February 19, 1991
    Assignee: Bristol-Myers Company
    Inventors: Kin S. Lam, Jacqueline Mattei, John E. Leet, James A. Matson, Koji Tomita, Murray A. Kaplan
  • Biological pure culture of Streptomyces violaceus ATCC 53807
    Patent number: 4992376
    Abstract: An new antibiotic having the chromophore structure of the pluramycin family of antibiotics is produced by fermentation of Streptomyces violaceus ATCC 53807. The new antibiotic designated BU-3839T, exhibits potent antibacterial activity and also inhibits the growth of tumors in experimental animal systems.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: February 12, 1991
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Keiko Shimizu, Masaru Ohbayashi, Koji Tomita, Takeo Miyaki, Toshikazu Oki
  • Bu-4061T
    Patent number: 4990448
    Abstract: A new antibiotic designated BU-4061T is produced by fermentation of actinomycete strain Q996-17 (ATCC-53904). The BU-4061T antibiotic exhibits both in vitro and in vivo antitumor activity.
    Type: Grant
    Filed: August 4, 1989
    Date of Patent: February 5, 1991
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Minoru Hanada, Yuji Nishiyama
  • N-(4-(3-aminopropyl)aminobutyl)-2-(.omega.-gua nidino-fatty-acid-amido(-2-substituted-ethanamide, salt thereof, and process for preparation thereof
    Patent number: 4983328
    Abstract: N-[4-(3-Aminopropyl)aminobutyl]-2-(.omega.-guanidino-fatty acid-amido)-2-substituted-ethanamides represented by the general formula ##STR1## wherein Y represents --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH or ##STR2## R represents a hydrogen atom, an alkyl group of 1 to 4 carbon atoms which may have a hydroxyl group as substituent, or a benzyl group, and n is an integer of from 1 to 8, provided that when Y is ##STR3## and n is 4, R represents the groups other than the hydrogen atom; salt thereof having antitumor activity in experimental animal tumors and a process for the preparation thereof is provided.
    Type: Grant
    Filed: March 15, 1988
    Date of Patent: January 8, 1991
    Assignee: Bristol-Myers Company
    Inventors: Hamao Umezawa, Tomio Takeuchi, Shinichi Kondo, Hironobu Iinuma, Daishiro Ikeda, Teruya Nakamura, Akio Fujii
  • Staurosporine fermentation process
    Patent number: 4973552
    Abstract: A fermentation process for preparing staurosporine, a known antibiotic, employing a heretofore unknown micrrorganism is described, said microorganism being classified as a novel strain of Streptomyces hygroscopicus being and herein designated Streptomyces hygroscopicus strain C39280-450-9 (ATCC 53730).
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: November 27, 1990
    Assignee: Bristol-Meyers Squibb Company
    Inventors: Daniel R. Schroeder, Kin S. Lam, Jacqueline M. Mattei, Grace A. Hesler
  • Antitumor antibiotic BU-3285T compounds
    Patent number: 4952709
    Abstract: The present invention relates to the antitumor antibiotic compound BU-3285T and its preparation. The compound is obtained by culturing a new strain of Chainia rosea and demonstrates both antitumor and antifungal activity. It also relates to the desulfated derivative of BU-3285T which is obtained by treatment of BU-3285T with sulfatase enzyme. BU-3285T desulfate possesses antitumor activity.
    Type: Grant
    Filed: November 3, 1989
    Date of Patent: August 28, 1990
    Assignee: Bristol Myers Company
    Inventors: Hiroaki Ohkuma, Koji Tomita, Masataka Konishi, Hideo Kamei