Abstract: Compounds that selectively inhibit dipeptidyl peptidase-IV over closely related dipeptidyl peptidases are those of Formula (I): as well as pharmaceutically acceptable salts thereof, cyclic isomers thereof, prodrugs thereof, and solvates thereof, where all the variables are defined herein. These compounds can be used, alone or in combination with other drugs, for the treatment of diabetes and related diseases.
Type:
Grant
Filed:
May 25, 2006
Date of Patent:
November 2, 2010
Inventors:
David Alan Campbell, David T. Winn, Juan Manuel Betancort
Abstract: Certain constrained cyano compounds are useful as inhibitors of post-proline/alanine cleaving amino-dipeptidases. Accordingly, these compounds can be employed, alone or with another therapeutic agent, to treat diabetes (especially, Type II diabetes), hyperglycemia, Syndrome X, diabetic complications, hyperinsulinemia, obesity, atherosclerosis and related diseases, as well as various immunomodulatory diseases and chronic inflammatory bowel disease.
Type:
Grant
Filed:
July 12, 2005
Date of Patent:
August 31, 2010
Inventors:
David Alan Campbell, Juan Manuel Betancort, David T. Winn