Patents Represented by Attorney, Agent or Law Firm David M. Stemerick
  • Process for preparing indane-like compounds
    Patent number: 6211364
    Abstract: The present invention provides intermediate for the preparation of indane-like compounds which are useful for the modulation of a muscarinic receptor.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: April 3, 2001
    Assignee: Eli Lilly and Company
    Inventors: Bret E Huff, Michael A Staszak, John S Ward
  • Heterocyclic compounds and their use
    Patent number: 6194416
    Abstract: The present invention relates to therapeutically active compounds of the formula: wherein G is an azacyclic or azabicyclic ring system, W is oxygen or sulfur, r is 0, 1, or 2, and R is defined in the specification; and to methods of treatment using, and pharmaceutical compositions comprising, these compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: February 27, 2001
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Jon K. Reel, John S. Ward, Celia A. Whitesitt
  • Heterocyclic compounds and their use
    Patent number: 6187776
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: February 13, 2001
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, John S. Ward
  • Heterocyclic compounds
    Patent number: 6187798
    Abstract: The present invention provides aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic receptor.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: February 13, 2001
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Lone Jeppesen, John S. Ward
  • Heterocyclic compounds
    Patent number: 6124312
    Abstract: The present invention provides heterocyclic 2-aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic ptor.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: September 26, 2000
    Assignee: Eli Lilly and Company
    Inventors: Charles H Mitch, Steven J Quimby, Jon K Reel, Celia A Whitesitt
  • Heterocyclic compounds
    Patent number: 6117883
    Abstract: The present invention provides heterocyclic compounds which are useful for modulating a muscarinic receptor.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: September 12, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Jon K Reel, Celia A Whitesitt, Richard L Simon
  • Method for treating bipolar disorder
    Patent number: 6117890
    Abstract: The present invention provides a method for treating or alleviating the symptoms of bipolar disorder, comprising administering an effective amount of xanomeline (3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine) .
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: September 12, 2000
    Assignee: Eli Lilly and Company
    Inventors: Franklin P Bymaster, Harlan E Shannon
  • Method for treating excessive aggression
    Patent number: 6090829
    Abstract: The present invention provides a method of treating conduct disorder in a human using a compound of formula (I) ##STR1##
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Neil C Bodick, Franklin P Bymaster, Harlan E Shannon
  • Heterocyclic compounds and their use
    Patent number: 6071900
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: June 6, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, John S. Ward
  • Heterocyclic compounds
    Patent number: 6069159
    Abstract: The present invention provides heterocyclic compounds which are useful for modulating a muscarinic receptor.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: May 30, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, Lone Jeppesen, John S Ward
  • Method for treating disruptive behavior disorders with xanomeline
    Patent number: 6043258
    Abstract: This invention relates to the use of xanomeline for the treatment of Disruptive Behavior Disorder and Attention Deficit Hyperactivity Disorder.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: March 28, 2000
    Assignee: Eli Lilly and Company
    Inventors: Franklin P Bymaster, Harlan E Shannon
  • Process for preparing 1,2,5-thiadiazole containing ethers
    Patent number: 6040442
    Abstract: The presently claimed process provides a method for preparing compounds of the formula ##STR1## phosphorous (III) compound and a diester of azodicarboxylate.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: March 21, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, John S. Ward
  • Method for treating mental retardation
    Patent number: 6034108
    Abstract: The present invention is directed to a method for using 3-(4-hexyloxy-1,2,5-thiadiazol-3yl)-1,2,5,6-tetrahydro-1-methylpyridine, i.e., xanomeline, for the treatment of autism and mental retardation.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: March 7, 2000
    Assignee: Eli Lilly and Company
    Inventors: Franklin P Bymaster, Harlan E Shannon
  • Heterocyclic compound and their use
    Patent number: 6030966
    Abstract: The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: February 29, 2000
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, John S. Ward
  • Process to make chiral compounds
    Patent number: 6008412
    Abstract: The present invention relates to processes for resolving N-methyl-3(R,S)-hydroxy-3-phenylpropylamine and N,N-dimethyl-3 (R,S) -hydroxy-3-phenylpropylamine with the isomers of mandelic acid and the resulting salts.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: December 28, 1999
    Assignee: Eli Lilly and Company
    Inventor: Andrew Michael Ratz
  • Composition for treating pain
    Patent number: 5998434
    Abstract: The present invention provides a composition and method for treating pain using Selected Muscarinic Compounds and one or more compounds selected from the group consisting of Nonsteroidal Anti-inflammatory drugs, acetaminophen, opioids, and alpha-adrenergic compounds.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: December 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: Charles H. Mitch, Harlan E. Shannon
  • Carboxysubstituted cyclic carboxamide derivatives
    Patent number: 5977139
    Abstract: The present invention relates to novel carboxy substituted cyclic carboxamide derivatives of formula (1), ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, coughs and bronchitis.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: November 2, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Timothy P. Burkholder, George D. Maynard, Elizabeth M. Kudlacz
  • NMDA (n-methyl-d-aspartate) antagonists
    Patent number: 5922752
    Abstract: The present invention is new excitatory amino acid antagonists (herein referred to as compounds of formula (1)): below: ##STR1## These new antagonists are useful as NMDA (N-methyl-D-aspartate) antagonists.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: July 13, 1999
    Assignee: Hoechst Marion Roussell, Inc.
    Inventors: Boyd L. Harrison, Raymond S. Gross, Bruce M. Baron
  • Process for preparing polyamine derivatives and intermediates thereof
    Patent number: 5874627
    Abstract: A process for preparing polyamines of the formula ##STR1## by selective introduction of the groups Z--CH.sub.2 -- at the terminal nitrogens from a polyamine having no nitrogen substituents by formation of bis-hexahydropyrimidine derivative, acylation, reduction of acyl group to give Z--CH.sub.2 --, and solvolysis.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: February 23, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Paul T. Angell, John Martin, Peter B. Anzeveno
  • Process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
    Patent number: 5872251
    Abstract: The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: February 16, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gary A. Flynn, Thomas D. Bannister