Patents Represented by Attorney David Preshker

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  • Pharmacologically effective antagonists of arginine-vasopressin
    Patent number: 5070187
    Abstract: A unique class of vasopressin analogue antagonists is provided which have the pharmacological property in-vivo to antagonize pressor (V.sub.1) and/or antidiuretic (V.sub.2) activities. The chemical modifications to the vasopressin 9 member chain sequence at the no. 1, 2, and 4 positions yield a class of potent analogue antagonists which may be employed therapeutically to treat hypertension, congestive heart failure, various edematous situations, and a variety of symptoms due to inappropriate vasopressin secretion.
    Type: Grant
    Filed: November 3, 1989
    Date of Patent: December 3, 1991
    Assignee: Trustees of Boston University
    Inventors: Haralambos Gavras, Bernard Lammek