Abstract: A method of isolating selected ion species in a quadrupole ion trap mass spectrometer is disclosed. One or more ranges of masses to be eliminated from the ion trap are ejected by applying a supplemental dipole excitation waveform, sparsely populated with frequency components, while the trapping field is modulated. The spacing of the frequency components in the supplemental excitation waveform varies across the range of frequencies in the waveform. Preferably, the frequency range is divided into a plurality of subranges, and the spacing of the frequency components in each of the subranges is constant. A method of creating a master set of frequencies used for generating a supplemental excitation waveform is also shown. Likewise, a method of calculating edge frequencies defining a gap in the mass spectrum that is excited by the supplemental waveform is also shown.

Abstract: A magnetron sputtering source which is capable of very low pressure operation is disclosed. The source comprises a dish-shaped sputter target behind which is mounted a primary magnet for confining a plasma discharge adjacent to the front surface of the sputter target. A bucking magnet, positioned adjacent to the perimeter of the sputter target and, preferably, at the same level as the target, is used to prevent the magnetic field created by the primary magnet from spreading out at near the edge of the sputter target. This enables the source to operate at very low pressure and reduces the impedance of the discharge.

Abstract: A method of isolating selected ion species in a quadrupole ion trap mass spectrometer is disclosed. One or more ranges of masses to be eliminated from the ion trap are ejected by applying a supplemental dipole excitation waveform, sparsely populated with frequency components, while the trapping field is modulated. The spacing of the frequency components in the supplemental excitation waveform varies across the range of frequencies in the waveform. Preferably, the frequency range is divided into a plurality of subranges, and the spacing of the frequency components in each of the subranges is constant. A method of creating a master set of frequencies used for generating a supplemental excitation waveform is also shown. Likewise, a method of calculating edge frequencies defining a gap in the mass spectrum that is excited by the supplemental waveform is also shown.

Abstract: A method of using a quadrupole ion trap mass spectrometer for high resolution mass spectroscopy is disclose. In the preferred embodiment, the space charge in the ion trap is controlled with high accuracy. The mass spectrum to be analyzed is divided into a plurality of contiguous mass segments and each of the segments is separately scanned. To control space charge, a broadband supplemental waveform is applied to the ion trap during the ionization period for each segment, the broadband signal being construct to eliminate all unwanted ions from the ion trap by resonance ejection such that only those ions having masses within the desired mass segment remain in the ion trap. Preferably, the ionization of each mass segment is performed under identical trapping conditions, and the ionization parameters for each segment is adjusted to optimize the space charge in the trap for that particular segment.

Abstract: A method of using a quadrupole ion trap mass spectrometer for high resolution mass spectroscopy is disclosed. In the preferred embodiment, the space charge in the ion trap is controlled to high accuracy. This is done by using a prescan of the trap before each analytical scan, where the ionization parameters used in the prescan are not fixed, but rather are based on the previous analytical scan. The method is especially useful in connection with performance of high resolution MS/MS experiments of the type described in the inventor's prior U.S. Pat. No. 5,198,665.

Abstract: A method of using a quadrupole ion trap mass spectrometer for high resolution mass spectroscopy is disclosed. High resolution of a mass spectrum of a desired species is achieved by first using a slow scanning rate and by first ridding the trap of unwanted ions. Accurate mass calibration is achieved by using a reference compound of known mass and using a second supplemental AC dipole voltage to eject the reference ions at nearly the same time as the sample ions of interest are ejected from the trap. This eliminates the need to scan the trap between the masses of the sample and reference ions. Space charge in the trap is held constant, thereby eliminating a major source of mass axis instability, by using the results of one scan to control the ionization time during the next scan. Preferably, during ionization a broadband supplemental dipole voltage is applied to the ion trap to rid it of unwanted ions.

Abstract: An improved transferred electron III-V semiconductor photocathode comprising an aluminum contact pad and an aluminum grid structure that improves quantum efficiency by removing a major obstacle to electrons escaping into the vacuum and controls dark spot blooming caused by overly bright photon emission sources.

Abstract: In a spectrophotometer having photodetectors positioned at fixed wavelengths, the photodetector is divided into three subdetectors, a main subdetector on the wavelength of interest and two background subdetectors located on each side of the main subdetector, the background subdetectors together having area equal to that of the main subdetector, the background subdetectors being connected in polarity reverse that of the main subdetector to correct for changes in background radiation.

Abstract: A method of correcting for background changes in a plasma emission detector comprising a photodetector array is disclosed. In the photodetector array a plurality of sensors are used to detect the emission lines from a discrete number of selected elements including carbon. It is shown that, to the first order, there is a correlation between the response at detectors other than the carbon detector with the response at a carbon detector. The exact extent of this correlation is highly dependent on the amount of nitrogen present in the carrier gas used in the system. A calibration curve can be generated which allows compensation at a frequency of interest as a function of the magnitude of the carbon signal. This curve will depend on the level of nitrogen in the carrier gas and can be empirically determined each time a new bottle of gas is connected to the system.

Abstract: A flame detector comprising a ceramic flame jet for use in a high temperature gas chromatography system is disclosed. The interior volume of the flame jet is fabricated of a highly inert ceramic material so that sample eluting from the end of a gas chromatography column located within the interior volume of the flame jet does not contact any metallic surface en route to the flame. By avoiding sample contact with metallic surfaces, interferences which are prone to occur at high temperature, such as peak tailing, are avoided. In a further aspect the flame detector is treated with a silylating reagent to further passivate the surfaces which may affect the sample.

Abstract: A small sample of material is introduced into a vacuum to be analyzed, by ionization of atoms or molecular fragments of the sample using an electron or photon beam. The ionized species are trapped in a structure that defines electric fields or a combination of electric and magnetic fields in such a way that their motions are confined to the interior of the trap and that their motions within the trap are characterized by unique and discrete frequencies of oscillation dependent on the mass-to-charge ratio of the individual species. In order to provide for the detection of the frequencies of the motions, additional electrical signals are applied to the trapping structure so as to cause the motions to take place with a considerable degree of coherence. Alternatively, the coherence may be caused by creation of the ions during a very short pulse of the electron or photon beam at a position within the trapping structure but displaced from a positon of equilibrium.

Abstract: A heat sink element, preferably one formed with a relatively large surface area from which thermal energy can be transferred convectively and radiatively to an ambient atmosphere, with or without forced fluid flow, is held forcibly in contact with a heat transmitting surface of a heat source for thermal conduction of heat therefrom. A heat sink attachment element affixed to the heat sink element has flexibly attached castellated extensions formed with tapered end teeth contacting a correspondingly inclined surface of the heat source. The castellated extensions are each subjected to a continual externally applied force and the total resultant force thereof, holding the heat sink element to the heat source, thereby can be maintained or will increase as the assembly experiences thermal cycling and mechanical disturbances during use. The effectiveness of thermally conductive contact between the heat sink and heat source therefore does not deteriorate during prolonged use.

Abstract: A monolithic microwave integrated circuit switch includes a series field effect transistor having a source drain path in series with an inductive transmission line including plural taps. Source drain paths of plural shunt field effect transistors are connected to the taps. The source drain paths of the series and shunt transistors are biased so that the series and shunt source drain paths have complementary low and high impedance states. The high impedance state is capacitive, having a value on the order of magnitude of the inductive transmission line. During a first time interval, the capacitive and inductive impedances form a matched low pass filter to supply current from a microwave source to a load. During a second time interval, current from the microwave source flows through the shunt field effect transistors to be decoupled from the load.

Abstract: Shown is an integral two-stage vacuum tube with means for efficient optical coupling of the light from an output screen of the first stage into the photocathode of the second stage.

Abstract: An X-ray tube exposure monitor for recording the emissions from a diagnostic X-ray tube. A photo diode is mounted inside the X-ray tube bulkhead and detects radiation from the X-ray tube. The photo diode is connected to a high gain amplifier and, in response to radiation being detected, the output of the amplifier sends an electronic signal to a microprocessor. The microprocessor records the emission duration and the temperature of oil around the X-ray tube and increments an exposure count. The recording and exposure count is stored in non-volatile memory which is read later by a service technician.

Abstract: An image intensifier tube comprising an input screen assembly which includes a photosensitive semiconductor wafer having a substrate of one conductivity type material forming a plurality of P-N junctions with a planar array of mutually isolated islands of opposite conductivity type material, the islands protruding substantially equal distances from a common surface of the substrate, an opaque film of resistive material overlying the exposed areas of the islands and the common surface of the substrate, a layer of electroluminescent material disposed in abutting relationship with the distal ends of the islands and a layer of photoemissive material disposed in axially aligned relationship with the electroluminescent layer.

Abstract: A method and apparatus for quantitatively analyzing, in a flowing stream, materials in a biological or chemical sample utilizes immobilized antobodies reversibly precharged with fluorescently labeled antigens. The labeled antigens are competitively displaced by unlabeled antigens in the sample, after the sample antigens have been segregated into zones by a chromatographic device, such as the reverse phase high performance liquid chromatograph. Displaced labeled antigens are measured by a fluorescence detector. A plurality of antibody species may be concurrently utilized, thereby allowing quantification of a plurality of antigens from a single sample.

Abstract: An x-ray rotor structure wherein a target support stem has an externally threaded end portion brazed to an internally threaded surface of an encircling bushing which is provided with a barrier layer of oxidation restricting material. The stem is made of predominantly molybdenum material and the bushing is made of iron cobalt nickel alloy material having therein a small percentage by weight of titanium. The barrier layer comprises a layer of substantially pure nickel material which coats the entire inner surface of the bushing including the internally threaded portion thereof. Thus, the titanium is restricted from leaching to the surface during brazing and forming oxides which prevent the surface from being completely wetted by the brazing material. As a result, during brazing, the liquified brazing material alloys with the nickel material of the barrier layer to wet the inner surface of the bushing completely.

Abstract: The invention relates to the functionalization of particulate bonded phase chromatographic supports prepared by silanization of silica gel or controlled pore glass and containing pendant primary alkyl amine groups. Functionalization results from the activation of the amines by reaction with N,N'-carbonyldiimidazole (CDI), or a related azolide, in anhydrous organic solvent, followed by derivatization of the support. Derivatization results from reaction of the activated support with a functionalizing reagent consisting of a primary or secondary, alkyl or aryl amine in organic solvent, or from an aqueous solution of the amine or its salt. A urea linkage results through which the functionalizing reagent is covalently attached to the support. Derivatization can result from the addition of an excess of a single reagent, or as a consequence of the sequential addition of two or more functionalizing reagents.

Abstract: An improved microprocessor-controlled autosampler for use in liquid chromatography is shown. The autosampler is fully programmable by the operator and capable of performing complex sample preparation routines. A spring-loaded sample needle is employed to ensure that the needle makes contact with the bottom of the sample vial as required, for example, when handling extremely small samples. A hollow vial lifter serves as the receptacle for waste wash solvent eliminating the need for a special waste receptacle mechanism. Other improved features include a plurality of interchangeable, codable sample racks, a four-way valve in the syringe line enabling rapid priming/purging of the hydraulics, and as improved vial stabilizer design.