Abstract: A syringe includes a body having a distal end, a proximal end and a center section therebetween, a plunger movably disposed in the body, and a hollow alignment flange for orienting and manipulating the syringe.

Abstract: The devices of the present disclosure are rheolytic thrombectomy catheters with a self-inflating distal balloon. A self-inflating balloon is located distal to an inflow gap or orifice and distal to a fluid jet emanator, which self-inflating balloon is inflated and expanded by the utilization of internal operating forces consisting of forwardly directed high velocity fluid jet streams and/or entrained thrombus particulate therein. The self-inflating balloon, when inflated, impinges on the wall of the blood vessel to isolate sections of the blood vessel distal and proximal to the inflated balloon in order to prevent flow of thrombus particulate, fluids and the like distal to the self-inflating balloon and to provide a stagnant nonflow region proximal to the self-inflating balloon. The devices of the present disclosure also provide for a uniform spacing of the catheter tube with respect to the thrombus and/or wall of the blood vessel.

Abstract: A catheter having a shaft that has at least two spaced-apart lumens is disclosed. A retractable core wire is disposed within at least one of the lumens. The retractable core wire is manipulated by the user to impart variable stiffness to the shaft as the core wire is retracted and extended within the lumen. A catheter having substantially low profile bonds at the junctions where an inflatable balloon is attached to the catheter is also disclosed. The low profile bonds are created by recesses extending around the circumference of the distal end of the shaft, the proximal and distal ends of a stem, and the proximal end of a tip. The catheter having the low profile bond optionally has either a retractable or an embedded core wire. In examples, the catheter has at least one component formed from, co-extruded with, or coated with a lubricious material or a hydrophilic material.

Abstract: The fluid delivery system includes a pressurizing device for delivering a pressurized injection fluid, a low pressure fluid delivery system, and a pressure isolation mechanism adapted for fluid communication with the pressurizing device and low pressure fluid delivery system. The pressure isolation mechanism includes a housing defining an inlet port, an isolation port, and an internal cavity. The housing defines a seal seat in the internal cavity between the inlet port and isolation port. A valve member is disposed in the internal cavity. The valve member is free floating in the internal cavity and is adapted to engage the seal seat. The valve member has an open position permitting fluid communication between the inlet port and isolation port, and is fluid flow responsive to fluid flow in the inlet port to engage the seal seat and attain a closed position preventing fluid flow between the inlet port and isolation port.

Abstract: A combined fluid injection and inflation system is disclosed and includes a fluid delivery system including at least one pressurizing device, a fluid path, and a control unit. The fluid path is adapted to connect the pressurizing device to a patient via a catheter including a balloon and inserted in the patient. The control unit is operable to control the fluid delivery system. In operation, the control unit selectively actuates the fluid delivery system to operate in a fluid injection mode or in a balloon inflation mode. In the fluid injection mode the pressurizing device delivers fluid to the fluid path for a fluid injection procedure. In the balloon inflation mode, the pressurizing device delivers fluid to the fluid path for inflating the balloon associated with the catheter. An operator control may be connected to the control unit for controlling the fluid delivery system and may be a handheld device.

Abstract: A system for delivering a fluid comprising cells to tissue of a patient includes a container holding an injection fluid and a powered drive. A sensor system provides a measurement indicative of at least shear forces on the cells to a control system. Based at least in part on this measurement, the control system is adapted to transmit a control signal to the powered drive for pressurizing the contents of the container to deposit cells within the tissue of a patient via a fluid path and a patient interface. As an example, the cells can be pregenitor or stem cells.

Abstract: A syringe includes a cylindrical body having a distal end and a proximal end, an injection section at the distal end and an expansion section at the proximal end, the injection section and the expansion section being connected by a cylindrical center section of relatively uniform outer diameter. The injection section includes a conical portion and an injection neck, the conical portion including an alignment flange extending outward from at least a portion of the conical portion. The syringe further includes a plunger movably received in the body and having a coupling end with a pair of flexible coupling members defining a slot therebetween for engaging a drive piston of an injector, the slot being substantially aligned with the alignment flange such that the alignment flange provides an indication of the orientation of the slot, the plunger seated for storage in the expansion section.

Abstract: An enhanced cross stream mechanical thrombectomy catheter with backloading manifold having a distal end with outflow and inflow orifices at one side for producing concentrated cross stream jet flow for selective and concentrated thrombus ablation during thrombectomy procedures. The invention provides for suitable distancing of high powered ablation or suction forces from the near walls of the vasculature. Cross stream flow emanating from the one side of the distal end of the catheter resultantly urges the distal end of the catheter and thus the opposing non-orificed side of the distal end of the catheter toward and against the vascular wall to inhibit contact of the inflow orifice with the vascular wall. Features of the invention include a geometrically configured insert to facilitate the backloading or exchange of guidewires.

Abstract: An exhaust-pressure-operated balloon catheter system which is a cross stream thrombectomy catheter, such as, but not limited to, an Angiojet® catheter with a flexible and expandable balloon, wherein the balloon is formed from and is continuous with the catheter tube which, in part, forms the cross stream thrombectomy catheter, wherein the balloon is deployable and expandable about the distal region of the cross stream thrombectomy catheter to act as an occluder device, and wherein the balloon is located proximal to the fluid jet emanator and inflow and outflow orifices upstream of ablative cross stream flows. The balloon is expandably deployed by the exhaust or back pressure created by the operation of the cross stream flows as generated by the fluid jets of the operating exhaust-pressure-operated balloon catheter system.

Abstract: The fluid injector system includes a source of injection fluid, a pump device, a fluid control device operably associated with the pump device, and a fluid path set in fluid connection with the source of injection fluid and the pump device. The fluid path set includes a drip chamber including an elongated body having a top end, a bottom end and a raised projection, the raised projection being substantially rectangular in shape and extending longitudinally from the top end along the drip chamber body and terminating adjacent to the bottom end. A fluid level sensing mechanism is operably associated with the fluid control device, and includes a drip chamber support for supporting the drip chamber body and a fluid level sensor associated with the drip chamber support.

Abstract: The present invention pertains to a miniature flexible thrombectomy catheter having one or more flexible miniature noncollapsing tubular portions including pushable and torqueable structure for introduction into the smaller vessels in neurovascular regions. A jet body having an arcuate fluid jet emanator is incorporated in order to minimize size at the distal portion of a minimally sized catheter tube.

Abstract: The present invention pertains to a miniature flexible thrombectomy catheter having one or more flexible miniature noncollapsing tubular portions including pushable and torqueable structure for introduction into the smaller vessels in neurovascular regions. A jet body having an arcuate fluid jet emanator is incorporated in order to minimize size at the distal portion of a minimally sized catheter tube.

Abstract: An intravascular platform for supporting an intravascular device includes two loops of wire each configured to assume a shape lying generally on a virtual cylinder of given diameter. The two loops are interconnected by at least one connecting wire which maintains the loops axially spaced from each other. Also disclosed are axially-extended loop forms, and associated intravascular devices.

Abstract: An atherectomy system having a variably exposed cutter wherein a distally located positionable tip closely associated with the cutter and a high pressure fluid jet emanator can be variably and angularly deployed about a hinge mechanism subsequent to entry into the vasculature. The fixed cutter slices or parts atheromatous material and/or thrombotic material from a blood vessel for interaction with high pressure jets to macerate, break up or otherwise reduce the materials for evacuation from the site.

Abstract: A thrombectomy catheter deployment system which greatly simplifies setup procedures and operation of a thrombectomy catheter includes a stand alone drive unit and a disposable pump/catheter assembly which is manually placed into a carriage assembly in the drive unit. The pump/catheter assembly has a plurality of preconnected components including tubular structure and a thrombectomy catheter connected thereto and is transported into or out of the interior of the drive unit for automatic high pressure pump piston head engagement or disengagement with a reciprocating linear actuator and for automatic engagement or disengagement of an effluent waste tube with a roller pump. A barcode reader senses specific operational data pertaining to an individual pump and provides an interface for operation of the reciprocating linear actuator. A bubble trap incorporated for effective debubbling of saline solution is closely coupled to an insert molded pump having an improved valve arrangement.

Abstract: A guidewire with collapsible filter system where a deployable, collapsible and retrievable filter attached to a guidewire tube is utilized for filtering thrombotic particulate from blood flow in the vascular system during thrombectomy or other interventional vascular procedures.

Abstract: A pneumatically-operated thrombectomy catheter deployment system having a plurality of components collectively acting as a drive unit, including a double-acting air cylinder, a reciprocating assembly including a positionable four-way valve, a high pressure pump, an effluent pump, a compressed air tank, and other closely related components. The double-acting air cylinder is reciprocatingly driven by the complement of the drive unit components to provide high pressure saline for use in the thrombectomy catheter and to exhaust effluent from the system. A plurality of preconnected components are connected to the drive unit including a thrombectomy catheter, a saline supply bag, an effluent collection bag, connection tubes, and other closely related components.

Abstract: A dual lumen aspiration catheter system with an aspiration catheter, a hub and a flexible strain relief, and a suction assembly. The aspiration catheter includes multiple successively connected flexible tubular components each increasing in relative flexibility in the distal direction, the most proximal tubular component connectingly extending from the hub and through the flexible strain relief. The tubular components of the aspiration catheter include, in order proximally to distally, a composite tube, an intermediate tube, a dual lumen tube, and a flexible tip tube. The dual lumen tube includes eccentrically co-located large and small tubular portions forming eccentrically co-located large and small lumens to provide a minimum cross section. The distal end of the dual lumen tube includes a convex beveled edge. The convex beveled edge and the flexible tip tube singly or jointly inflict minimal traumatic contact with a vessel wall when urged along a tortuous vascular path.

Abstract: A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.

Abstract: An adapter includes a syringe carrier adapted to seat at least a portion of the syringe. The syringe carrier includes at least one rearward facing abutmer member to abut at least one forward facing surface on a syringe. The syringe carrie includes an opening therein to allow a drive member of an injector to communicate forward force to the plunger through abutment without connective engagement between the drive member and the plunger. The adapter further includes a releasable mounting mechanism positioned to the rear of the syringe carrier to mount the adapter in a desired position relative to the front wall of the injector. An adapter includes a first section and a second section that are rotatable relative to each other about a hinge axis generally perpendicular to a longitudinal axis of the adapter.