Patents Represented by Attorney, Agent or Law Firm David Spolter
  • Ribozyme therapy for the treatment of proliferative skin and eye diseases
    Patent number: 6770633
    Abstract: As an effective therapy for proliferative skin and eye diseases such as psoriasis and proliferative diabetic retinopathy, this invention provides ribozymes and ribozyme delivery systems which cleave RNA encoding cytokines involved in inflammation, matrix metalloproteinases, a cyclin, a cell-cycle dependent kinase, a growth factor, or a reductase.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: August 3, 2004
    Assignee: Immusol, Inc.
    Inventors: Joan M. Robbins, Richard Tritz
  • Triamine derivative melanocortin receptor ligands and methods of using same
    Patent number: 6768024
    Abstract: The invention provides triamine derivative melanocortin receptor ligands of the formula: wherein R1 to R8 and n have the meanings provided herein. The invention further provides methods of using the ligands to alter or regulate the activity of a melanocortin receptor.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: July 27, 2004
    Assignee: Lion Bioscience AG
    Inventors: Karen J. Watson-Straughan, Timothy C. Gahman, Ming Qi, Christa Hamashin, James E. Macdonald, Michael J. Green, Kevin R. Holme, Michael C. Griffith
  • Pyridine carboxamide or sulfonamide derivatives and combinatorial libraries thereof
    Patent number: 6677452
    Abstract: The present invention relates to novel pyridine carboxamide or sulfonamide derivative compounds of the following formula: wherein R1 to R6 have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing pyridine carboxamide or sulfonamide derivative compounds.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: January 13, 2004
    Assignee: Lion Bioscience AG
    Inventors: Yuewu Chen, Hengyuan Lang, Yazhong Pei
  • Tetracyclic benzimidazole derivatives and combinatorial libraries thereof
    Patent number: 6515122
    Abstract: The present invention relates to novel tetracyclic benzimidazole derivative compounds of the following formula: wherein R1 to R10 have the meanings described in here. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing tetracyclic benzimidazole derivative compounds.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: February 4, 2003
    Assignee: Lion Bioscience AG
    Inventors: Hengyuan Lang, Yazhong Pei
  • 2-aminopyridine derivatives and combinatorial libraries thereof
    Patent number: 6458789
    Abstract: The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R1 to R5 have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminopyridine derivative compounds.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: October 1, 2002
    Assignee: Lion Bioscience AG
    Inventors: Behrouz Forood, Brenton T. Flatt, Christophe Chassaing, Alan K. Katritzky
  • Hepatitis C Virus ribozymes
    Patent number: 6458567
    Abstract: This invention provides ribozymes useful to treat or prevent Hepatitis C Virus (“HCV”) infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes usefull in methods of treatment and prevention of HCV infection or disease are also provided.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: October 1, 2002
    Assignee: Immusol, Inc.
    Inventors: Jack R. Barber, Peter J. Welch, Richard Tritz, SoonPin Yei, Mang Yu
  • 4-unsubstituted dihydroisoquinolinone derivatives and combinatorial libraries thereof
    Patent number: 6452009
    Abstract: The present invention relates to novel dihydroisoquinolinone (DHQ) derivative compounds of the following formula: wherein R1 to R7, X, Y, Z, b, c and d have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing DHQ derivative compounds.
    Type: Grant
    Filed: August 19, 1999
    Date of Patent: September 17, 2002
    Assignee: Lion Bioscience AG
    Inventors: Kianoush Motesharei, Michal Lebl, Viktor Krchnak, Yidong Ni
  • Isoquinoline derivatives and isoquinoline combinatorial libraries
    Patent number: 6417195
    Abstract: The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: July 9, 2002
    Assignee: Lion Bioscience AG
    Inventor: Michal Lebl
  • 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries
    Patent number: 6388081
    Abstract: The present invention relates to novel 4-substituted quinoline compounds of the following formula, libraries containing such compounds, and to the generation of such combinatorial libraries composed of such compounds: wherein R1, R2, R3, R4, R5, R6, R7, R9, and Y, have the meanings provided.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: May 14, 2002
    Assignee: Lion bioscience AG
    Inventors: Thomas K. Hayes, Behrouz Forood, John S. Kiely
  • Triazole compounds and methods of making same
    Patent number: 6362342
    Abstract: The present invention relates to novel triazole compounds of the following formula: wherein R1 to R5 have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing triazole compounds.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: March 26, 2002
    Assignee: Lion Bioscience AG
    Inventors: Ming Qi, R. Normand Hebert, Alan R. Katritzky
  • Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
    Patent number: 6359144
    Abstract: The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: March 19, 2002
    Assignee: Lion Bioscience AG
    Inventors: John M. Ostresh, Jean-Philippe Meyer, Colette T. Dooley, Sylvie E. Blondelle, Christa C. Schoner, Richard A. Houghten
  • 4-Substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries
    Patent number: 6262269
    Abstract: The present invention relates to novel 4-substituted quinoline compounds of the following formula, libraries containing such compounds, and to the generation of such combinatorial libraries composed of such compounds: wherein R1, R2, R3, R4, R5, R6, R7, R9, and Y, have the meanings provided.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: July 17, 2001
    Assignee: Trega Biosciences, Inc.
    Inventors: Thomas K. Hayes, Behrouz Forood, John S. Kiely