Patents Represented by Attorney, Agent or Law Firm David Spolter
  • 4-unsubstituted dihydroisoquinolinone derivatives and combinatorial libraries thereof
    Patent number: 6452009
    Abstract: The present invention relates to novel dihydroisoquinolinone (DHQ) derivative compounds of the following formula: wherein R1 to R7, X, Y, Z, b, c and d have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing DHQ derivative compounds.
    Type: Grant
    Filed: August 19, 1999
    Date of Patent: September 17, 2002
    Assignee: Lion Bioscience AG
    Inventors: Kianoush Motesharei, Michal Lebl, Viktor Krchnak, Yidong Ni
  • Isoquinoline derivatives and isoquinoline combinatorial libraries
    Patent number: 6417195
    Abstract: The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: July 9, 2002
    Assignee: Lion Bioscience AG
    Inventor: Michal Lebl
  • 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries
    Patent number: 6388081
    Abstract: The present invention relates to novel 4-substituted quinoline compounds of the following formula, libraries containing such compounds, and to the generation of such combinatorial libraries composed of such compounds: wherein R1, R2, R3, R4, R5, R6, R7, R9, and Y, have the meanings provided.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: May 14, 2002
    Assignee: Lion bioscience AG
    Inventors: Thomas K. Hayes, Behrouz Forood, John S. Kiely
  • Triazole compounds and methods of making same
    Patent number: 6362342
    Abstract: The present invention relates to novel triazole compounds of the following formula: wherein R1 to R5 have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing triazole compounds.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: March 26, 2002
    Assignee: Lion Bioscience AG
    Inventors: Ming Qi, R. Normand Hebert, Alan R. Katritzky
  • Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
    Patent number: 6359144
    Abstract: The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: March 19, 2002
    Assignee: Lion Bioscience AG
    Inventors: John M. Ostresh, Jean-Philippe Meyer, Colette T. Dooley, Sylvie E. Blondelle, Christa C. Schoner, Richard A. Houghten