Abstract: The present invention relates to a method for reducing the amount of substances inhibitory to nucleic acid hybridization in samples. The method is practiced prior to release of target nucleic acid from cells of interest and involves contacting the sample with an agent which solubilizes the inhibitory substances and does not effectuate release of nucleic acids from cells in the sample, and then the cells from the agent.
Type:
Grant
Filed:
December 30, 1996
Date of Patent:
June 9, 1998
Assignee:
Becton Dickinson and Company
Inventors:
Matthew P. Collis, Michael C. Little, Oscar J. Llorin