Abstract: A medication infusion system may include a controller and a reservoir module including a reservoir containing medication to be delivered to an internal wound site via the controller. The controller may have a peristaltic pump driven by a motor to urge medication to flow toward the internal wound site, through a conduit. When the conduit is not tensioned via engagement with the pump, a valve blocks fluid flow to prevent unrestricted flow of medication. The valve may have a tapered plunger separated from an annular valve seat by a portion of the conduit that elongates under tension to enable withdrawal of the plunger from the valve seat. Alternatively, the valve may have features such as a spherical plunger between two annular valve seats, a rigid tubular member biased with respect to the conduit, or an opening in the conduit that moves axially or radially to enable fluid flow.