Abstract: Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.
Type:
Grant
Filed:
August 25, 2004
Date of Patent:
December 12, 2006
Assignee:
3M Innovative Properties Company
Inventors:
John F. Gerster, Kyle J. Lindstrom, Gregory J. Marszalek
Abstract: Imidazopyridine compounds that contain an ether or thioether functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
Type:
Grant
Filed:
August 11, 2004
Date of Patent:
October 24, 2006
Assignee:
3M Innovative Properties Company
Inventors:
Joseph F. Dellaria, Kyle J. Lindstrom, Luke T. Dressel, Daniel E. Duffy, Philip D. Heppner, John R. Jacobsen, Joan T. Moseman, William H. Moser, Matthew R. Radmer, Doris Stoermer, Bernhard M. Zimmermann
Abstract: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
Type:
Grant
Filed:
August 10, 2005
Date of Patent:
August 29, 2006
Assignee:
3M Innovative Properties Company
Inventors:
Philip D. Heppner, Kyle J. Lindstrom, Bryon A. Merrill
Abstract: Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds arc useful, inter alia, for determining the binding and/or receptor sites of the molecules.
Type:
Grant
Filed:
July 22, 2003
Date of Patent:
July 12, 2005
Assignee:
3M Innovative Properties Co.
Inventors:
Michael J. Rice, Mark A. Tomai, Ai-Ping Wei
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