Patents Represented by Attorney, Agent or Law Firm Deborah A. Martin
  • Polynucleotides encoding antibodies directed against amyloid-beta peptide
    Patent number: 8268593
    Abstract: Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and A? peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and A? peptide associated diseases are also described.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: September 18, 2012
    Assignee: Rinat Neuroscience Corp.
    Inventors: Arnon Rosenthal, Jaume Pons, Wei-Hsien Ho, Jan Markus Grimm
  • Methods for treating obesity by administering a trkB antagonist
    Patent number: 7935342
    Abstract: This invention relates to methods for treating obesity by peripheral administration of a trkB antagonist. The invention also relates to compositions and kits comprising a trkB antagonist.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: May 3, 2011
    Assignee: Rinat Neuroscience Corp.
    Inventors: John Chia-Yang Lin, Arnon Rosenthal
  • Modulation of PDE11A activity
    Patent number: 6828473
    Abstract: The invention provides genetically-modified non-human mammals and genetically-modified animal cells containing a functionally disrupted PDE11A gene. Also provided by the invention are methods of screening for agents that modulate PDE11A to modulate spermatogenesis, methods of treating mammals to modulate spermatogenesis, and methods of modulating cAMP and cGMP signal transduction in cells that express PDE11A.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: December 7, 2004
    Assignee: Pfizer Inc.
    Inventors: Martyn Frank Burslem, Ian Dennis Harrow, Jeremy Lanfear, Stephen Charles Phillips
  • Polynucleotide encoding neuromedin U receptor
    Patent number: 6780611
    Abstract: Polynucleotide and polypeptide sequences are described. The polypeptide sequences comprise one or more of: (a) a polypeptide having the deduced amino acid sequence translated from the polynucleotide sequence in SEQ ID NO: 1 and variants, fragments, homologues, analogues and derivatives thereof; (b) a polypeptide of SEQ ID NO: 2 and variants, fragments, homologues, analogues and derivatives thereof; or (c) a polypeptide encoded by the cDNA of NCIMB 41066 and variants, fragments, homologues, analogues and derivatives thereof.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: August 24, 2004
    Assignee: Pfizer Inc.
    Inventor: Lee Harland
  • Nucleic acid encoding a C5A anaphylatoxin receptor
    Patent number: 6692936
    Abstract: Polynucleotide and polypeptide sequences are described. The polypeptide sequences comprise one or more of: (a) a polypeptide having the deduced amino acid sequence translated from the polynucleotide sequence in SEQ ID NO: 1 and variants, fragments, homologues, analogues and derivatives thereof; (b) a polypeptide of SEQ ID NO: 2 and variants, fragments, homologues, analogues and derivatives thereof; or (c) a polypeptide encoded by the cDNA of NCIMB 41067 and variants, fragments, homologues, analogues and derivatives thereof.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: February 17, 2004
    Assignee: Pfizer Inc.
    Inventor: Lee Harland