Abstract: A gastric balloon and method of adding and removing fluid therefrom are disclosed. The gastric balloon includes a shell, a receiver, and a retractable tubing housed in the receiver and extendable from the stomach of a patient to the mouth of the patient. The shell is inflated and deflated from outside the body of the patient. The method of adding or removing fluid from the implanted gastric balloon includes steps of inserting a gastroscopic tool into the stomach of a patient and grasping an end of a retractable tubing housed in a receiver of the gastric balloon. Further steps of the method include withdrawing at least a portion of the retractable tubing from the stomach and out of a patient's mouth and adding or removing fluid from the gastric balloon via the retractable tubing withdrawn from the patient.

Abstract: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor.

Abstract: A valve rotator comprising a body having a generally annular peripheral surface at one end of the body and a central cavity opening at such end. The annular peripheral surface substantially surrounds the central cavity and has an interlocking surface region configured to interlock with a rotor of a rotatable valve. The body had a generally annular shoulder adjacent such one end which generally faces such end of the body. The annular peripheral surface extends toward that end of the body from the annular shoulder.

Abstract: An assembly for holding a substantially flexible annuloplasty ring in a substantially taunt position for suturing about a valve annulus. The assembly includes a portion which is formed with a surface against which the annuloplasty ring is positioned and held in a shape substantially equivalent to at least a portion of the valve annulus. The assembly further includes a mechanism for releasably binding the annuloplasty ring to this surface.

Abstract: A guidewire having a centrally located core wire about which is mounted a single outer helical coil spring. The core wire is typically longer than the outer helical coil spring, with the helical coil spring and core wire having common distal ends. The spring is brazed at both its distal and proximal end to the core wire. The distal brazing of the core wire and helical coil springs is rounded. A second small radiopaque helical coil spring is fitted in the distal end of the outer helical coil spring and may be brazed to the core wire and outer helical coil spring.