Abstract: The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septic shock and multiple organ failure. A series of studies also have indicated the involvement HNE in myocardial ischemia-reperfusion injury, emphysema. HNE-mediated processes are implicated in other conditions such as arthritis, periodontal disease, glomerulonephritis, dermatitis, psoriasis, cystic fibrosis, chronic bronchitis, atherosclerosis, Alzheimer's disease, organ transplantation, corneal ulcers, and invasion behavior of malignant tumors.

Abstract: The present invention relates to oxadiazole, thiadiazole, and triazole peptoids that are inhibitors of serine protease, specifically human neutrophil elastase; which proteases are useful in treatment of adult respiratory distress syndrome, septic shock, and multiple organ failure.

Abstract: The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the following formulas I and II: ##STR1## or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to certain substituted oxadiazole, thiadiazole, and triazole peptoids that are useful as inhibitors of serine proteases, in particular human neutrophil elastase. Serine protease inhibitors of the invention are useful in the treatment of, for example, adult respiratory distress syndrome, septic shock, and myocardial ischemia-reperfusion injury.

Abstract: Provided are a container comprising a tabbed sealing unit, blister pack containers comprising such sealing units, and methods of making such sealing units and containers.

Abstract: The present invention relates to materials and methods for the identification of agents that regulate glycine transport in or out of cells, particularly in or out of neuronal and neuronal-associated cells. Such materials include non-mammalian cells having transfected therein a glycine transporter. The methods relate to the manipulation of such cells such that agents are identified that cause intake or outflow of glycine with respect to a given glycine transporter.

Abstract: The invention provides the DNA and amino acid sequence of dUTPase, an enzyme which is essential for life and which is increased during periods of cellular proliferation. The human form of the dUTPase enzyme has been found to have two isoforms, a nuclear and a mitochondrial isoform. Methods of determining the proliferation status of a cell, efficacy of antineoplastic compounds, and response to therapy with antineoplastic compounds, using cellular levels of dUTPase is disclosed. A kit containing the necessary reagents for the determination of dUTPase is also disclosed.

Abstract: The invention relates to a multifunctional enzyme that can be derived from crustaceans or fish. The enzyme has at least one of a chymotrypsin, trypsin, elastase, collagenase and exo peptidase activity, and a molecular weight between about 20 kd and about 40 kd as determined by SDS PAGE. Preferably, the multifunctional enzyme has substantial anti cell-cell adhesion activity. Preferably, the multifunctional enzyme has substantial homology with the krill multifunctional enzyme. These enzymes are useful for treating viral infections such as herpes outbreaks, fungal, bacterial or parasitic infections, including the primary and secondary infections of leprosy, colitis, ulcers, hemorrhoids, corneal scarring, dental plaque, acne, cystic fibrosis, blood clots, wounds, immune disorders including autoimmune disease and cancer. Additionally, the invention relates to a method of purifying the multifunctional enzyme, and to a preparation of essentially purified multifunctional enzyme.

Abstract: The present invention provides for golf clubs, in particular woods, which include a three dimensional weighting system including at least two weight ports which are attached to the outside of the clubhead. The weights are directly axially aligned to, and form an equilateral triangle with the clubs center of gravity. The weights are preferably located in close proximity to the sole plate of the club in the rear toe and heel position. The two double sided, from top to bottom weights, facilitate vertical, horizontal and lateral movement of the club's center of gravity. The weights are made of various densities which can easily be interchanged to make the club lighter or heavier. This weighting system allows for individual customization of the club to increase or decrease the hooking or slicing of the ball. It also enables the club to have the greatest possible expansion of the moment of inertia, as well as the ability to lower or raise the clubs center of gravity to customize shot trajectory.

Abstract: The invention relates to a multifunctional enzyme that can be derived from crustaceans or fish. The enzyme has at least one of a chymotrypsin, trypsin, elastase, collagenase and exo peptidase activity, and a molecular weight between about 20 kd and about 40 kd. Preferably, the multifunctional enzyme has substantial anti cell-cell adhesion activity. Preferably, the multifunctional enzyme has substantial homology with the krill multifunctional enzyme. These enzymes are useful for treating viral infections such as herpes outbreaks, fungal, bacterial or parasitic infections, including the primary and secondary infections of leprosy, colitis, ulcers, hemorrhoids, corneal scarring, dental plaque, acne, cystic fibrosis, blood clots, wounds, immune disorders including autoimmune disease and cancer. Additionally, the invention relates to a method of purifying the multifunctional enzyme, and to a preparation of essentially purified multifunctional enzyme.

Abstract: The invention provides nucleic acids and proteins derived from the sequence of the human GlyT-2 transporter of the amino acid glycine.

Abstract: The invention provides a method of treating or preventing a fungal infection comprising administering to a plant having a fungal infection a composition comprising an effective amount of a compound of formula I, wherein said compound is the following or an agriculturally acceptable salt of the following: ##STR1## The invention further provides such compounds and related methods.

Abstract: The present invention is directed, among other things, to methods for reducing fouling of a separation membrane having a concentrate side subject to a concentrate pressure (Pc) and a permeate side subject to permeate pressure (Pp), comprising raising an initial permeate pressure (Pp.sub.0) to an increased permeate pressure (Pp.sub.1). The present invention further provides a method of reducing fouling of a membrane having a concentrate side subject to a concentrate pressure (Pc) and a permeate side subject to permeate pressure (Pp), comprising periodically raising an initial permeate pressure (Pp.sub.0) to an increased permeate pressure (Pp.sub.1).

Abstract: The present invention relates to a perfumery material composed of a mixture of 3-methyl-5-phenyl-pentanenitrile and 3-methyl-5-cyclohexyl-pentanenitrile, which can be combined with other perfumery materials.

Abstract: The invention provides to a prefabricated appliance for correcting many types of malocclusions typically with no more than limited use of wires or bands. The appliance is designed to be fitted stably and tightly to the upper front teeth or back teeth when needed. The appliance comprises: a teeth engaging box adapted to engage the upper front teeth; a stabilizing segment attached to the teeth engaging box and adapted to permit a stable and comfortable fitting of the appliance in a patient's mouth; and a pair of spaced inclined remodeling segments extending from in front of the teeth engaging box downward and rearward at a predetermined angle designed so that the inclined remodeling segments contact the lingual contacting surface of selected lower front teeth and urge the lower jaw forward and upward to the desired degree.

Abstract: The present invention is directed to nucleic acid sequences encoding a limbic-system associated membrane protein ("LAMP") and to purified proteins with LAMP activity. LAMP is a self-binding, antibody-like cell surface adhesion protein, the presence of which on one neuron of the limbic system stimulates the formation of connections with adjacent neurons. The invention provides a nucleic acid sequence encoding a polypeptide with at least about 90% homology to a LAMP self-binding domain, and corresponding proteins. The invention also provides nucleic acids that hybridize to LAMP encoding nucleic acids.

Abstract: The invention provides a method of treating a fungal infection comprising administering to an animal having a fungal infection a composition comprising an infection treating effective amount of a compound of formula I, wherein said compound is the following or a pharmaceutically acceptable salt of the following: ##STR1## The invention further provides such compounds and related methods.

Abstract: The present invention relates to, among other things, methods of treatment of migraine headache in humans with reduced side effects by the topical administration of a migraine-ameliorating effective amount of an opioid, singly, or in combination with other pharmacological agents, including vasoconstrictors, antiinflammatory agents, antimicrobial agents, decongestants and non-opioid migraine drugs.

Abstract: The present invention relates to making precocious neomorphic embryoids (PNE) and their use for producing biological products. Specifically, the invention provides a method for increasing taxol production from embryogenic Taxus cultures by making precocious neomorphic embryoids.The invention further provides methods of inducing somatic embryogenesis in tissue cultures derived from varieties of Taxus. In addition, the present invention provides methods of obtaining taxol, or precursors thereof, using in vitro propagated somatic embryo tissues.

Abstract: Provided is a compound containing a peptide of at least 4 amino acids including the following sequence: His Phe* Arg, wherein Phe* represents phenylalanine or a halogenated derivative of phenylalanine the said peptide being conjugated with thioctic acid, dihydrolioic acid, or N-lipoyl-lysine, in the form of the corresponding salts, esters or amides. In particular, compounds with anti-allergic and anti-inflammatory activities on the one had, and melanogenesis-activating activities on the other, are described.