Patents Represented by Attorney, Agent or Law Firm Deidre L. Conley
  • Antibodies to leukemia inhibitory factor and their use in immunoassays
    Patent number: 6544749
    Abstract: The invention relates to monoclonal antibodies to human leukemia inhibitory factor. The disclosed monoclonal antibodies are believed to recognize unique epitopes on hLIF and are useful in the treatment of conditions wherein the presence of hLIF causes or contributes to undesirable pathological effects, such as cachexia, dysregulated calcium metabolism, or excessive bone cell proliferation, and in the detection of hLIF, for example, in clinical samples or specimens.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: April 8, 2003
    Assignee: Genentech, Inc.
    Inventor: Kyung Jin Kim
  • Luteinizing hormone/choriogonadotropin (LH/CG) receptor
    Patent number: 6261800
    Abstract: The invention relates to the purification, and cloning of receptors for the luteinizing hormone, choriogonadotropin, follicle stimulating hormone, and thyroid stimulating hormone. The invention additionally concerns the uses for such molecules in the diagnosis and therapy of human conditions.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: July 17, 2001
    Assignee: Genentech, Inc.
    Inventors: Karoly Nikolics, Keith C. McFarland, Deborah L. Segaloff, Peter H. Seeburg
  • ErbB4 receptor-specific neuregolin related ligands and uses therefor
    Patent number: 6121415
    Abstract: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: September 19, 2000
    Assignee: Genentech, Inc.
    Inventors: Paul J. Godowski, Melanie Rose Mark, Dong Xiao Zhang
  • Assay for growth promoting factors utilizing mammalian lung cell lines
    Patent number: 5736345
    Abstract: A novel bronchial or bronchiolar epithelial cell from normal neonatal mammalian lung has been isolated, established and maintained for multiple passages in the absence of serum, without undergoing crisis or senescence. By careful manipulation of the nutritional/hormonal microenvironment we have been able to select, from a heterogeneous population, a single epithelial cell type which can maintain highly differentiated features in vitro. This cell type has characteristics of bronchiolar epithelial cells. A clonal line, RL-65, has been selected and observed for more than 3 years in continuous culture. It has been characterized by ultrastructural, morphological and biochemical criteria.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 7, 1998
    Assignee: Genentech, Inc.
    Inventors: Jennie P. Mather, Penelope E. Roberts