Patents Represented by Attorney Dennis Bennett

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  • Therapeutic uses of interleukin-3 (IL-3) multiple mutation polypeptides
    Patent number: 6051217
    Abstract: The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids (a.a.119 to 133) have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 18, 2000
    Assignee: G. D. Searle & Co.
    Inventors: S. Christopher Bauer, Mark Allen Abrams, Sarah Ruth Braford-Goldberg, Maire Helena Caparon, Alan Michael Easton, Barbara Kure Klein, John P. McKearn, Peter O. Olins, Kumnan Paik, John W. Thomas
  • Amidino derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5821267
    Abstract: The current invention discloses amidino derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: October 13, 1998
    Assignee: G.D. Searle & Co.
    Inventors: Kam F. Fok, Foe S. Tjoeng, R. Keith Webber