Patents Represented by Attorney Dennis K. Shelton
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Patent number: 7250443Abstract: New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.Type: GrantFiled: August 21, 2003Date of Patent: July 31, 2007Assignee: Chiron CorporationInventors: Manoj C. Desai, Simon Ng, Zhi-Jie Ni, Keith B. Pfister, Savithri Ramurthy, Sharadha Subramanian, Allan S. Wagman
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Patent number: 7071216Abstract: New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.Type: GrantFiled: March 31, 2003Date of Patent: July 4, 2006Assignee: Chiron CorporationInventors: Paul A. Renhowe, Savithri Ramurthy, Payman Amiri, Barry Haskell Levine, Daniel J. Poon, Sharadha Subramanian, Leonard Sung, Wendy Fantl, Teresa Hansen, Christopher McBride, Cynthia M. Shafer
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Patent number: 7053097Abstract: Compounds of formula 1: wherein R1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0–3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R2 is hydroxy, amino, or lower alkoxy; R3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl; R4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.Type: GrantFiled: November 6, 2000Date of Patent: May 30, 2006Assignee: Chiron CorporationInventors: Peter Schultz, David B. Ring, Stephen D. Harrison, Andrew M. Bray
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Patent number: 7037918Abstract: New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.Type: GrantFiled: December 3, 2002Date of Patent: May 2, 2006Assignee: Chiron CorporationInventors: John M. Nuss, Stephen D. Harrison, David B. Ring, Rustum S. Boyce, Sean P. Brown, Dane A. Goff, Kirk W. Johnson, Keith B. Pfister, Savithri Ramurthy, Paul A. Renhowe, Lynn Seely, Sharadha Subramanian, Allan S. Wagman, Xiaohui A. Zhou
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Patent number: 6890907Abstract: A patient suffering from an endobronchial infection is treated by administering to the patient for inhalation a dose of less than about 4.0 ml of a nebulized aerosol formulation comprising from about 60 to about 200 mg/ml of an aminoglycoside antibiotic, such as tobramycin, in a physiologically acceptable carrier in a time period of less than about 10 minutes. Unit dose devices for storage and delivery of the aminoglycoside antibiotic formulations are also provided.Type: GrantFiled: December 22, 2003Date of Patent: May 10, 2005Assignee: Chiron CorporationInventors: Robert John Speirs, Barbara Ann Schaeffler, Peter Bruce Challoner
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Patent number: 6800632Abstract: New bicyclic based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.Type: GrantFiled: December 15, 2000Date of Patent: October 5, 2004Assignee: Chiron CorporationInventors: John M. Nuss, Xiaohui A. Zhou
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Patent number: 6756359Abstract: Antimicrobial macrolide compounds are provided having formulas II: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.Type: GrantFiled: July 3, 2002Date of Patent: June 29, 2004Assignee: Chiron CorporationInventors: Daniel Chu, Matthew Burger, Xiaodong Lin, Georgia Law Carroll, Jacob Plattner, Alice Rico
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Patent number: 6608063Abstract: New bicyclic based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.Type: GrantFiled: December 14, 2000Date of Patent: August 19, 2003Assignee: Chiron CorporationInventors: John M. Nuss, Savithri Ramurthy
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Patent number: 6489344Abstract: New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.Type: GrantFiled: June 18, 1999Date of Patent: December 3, 2002Assignee: Chiron CorporationInventors: John M. Nuss, Stephen D. Harrison, David B. Ring, Rustum S. Boyce, Sean P. Brown, Dane A. Goff, Kirk W. Johnson, Keith B. Pfister, Savithri Ramurthy, Paul A. Renhowe, Lynn Seely, Sharadha Subramanian, Allan S. Wagman, Xiaohui A. Zhou
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Patent number: 6417185Abstract: Novel pyridine and pyrimidine derivatives which selectively inhibit glycogen synthase kinase 3 are provided and methods of preparing these compounds are provided. These compounds are useful in treating certain conditions which may be mediated by glycogen synthase kinase 3.Type: GrantFiled: June 18, 1999Date of Patent: July 9, 2002Assignee: Chiron CorporationInventors: Dane A. Goff, Stephen D. Harrison, John M. Nuss, David B. Ring, Xiaohui A. Zhou
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Method for the treatment of severe chronic bronchitis (bronchietasis) with an aerosolized antibiotic
Patent number: 6387886Abstract: The present invention is directed to a method for the treatment of severe chronic bronchitis, i.e., bronchiectasis, using a concentrated aminoglycoside antibiotic formulation delivering the antibiotic to the lung endobronchial space, including alveoli, in an aerosol or dry powder having a mass medium diameter predominately between 1 to 5 microns.Type: GrantFiled: November 28, 2001Date of Patent: May 14, 2002Assignee: Chiron CorporationInventors: Alan B. Montgomery, William R. Baker -
Patent number: 6153618Abstract: Compounds of formula 1: ##STR1## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0-3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro;R.sub.2 is hydroxy, amino, or lower alkoxy;R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amnino-acyl;R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.Type: GrantFiled: October 10, 1997Date of Patent: November 28, 2000Assignee: Chiron CorporationInventors: Peter Schultz, David B. Ring, Stephen D. Harrison, Andrew M. Bray
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Patent number: 5066426Abstract: This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure and to a novel class of tracer compounds employed as reagents in such procedures. The procedure disclosed combines the specificity of an immunoassay with the speed and convenience of fluorescence polarization techniques to provide a means for determining the amount of a specific ligand present in a sample.Type: GrantFiled: August 23, 1984Date of Patent: November 19, 1991Assignee: Abbott LaboratoriesInventors: Chao-Huei J. Wang, Stephen D. Stroupe, Michael E. Jolley
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Patent number: 4776832Abstract: An improved centrifuge, including a main wheel for rotating objects to be subjected to centrifugal force about a main axis of rotation, is disclosed. Such objects are simultaneously rotated about a second axis of rotation from a first to a second position, and the centrifuge is improved by the inclusion therein of multiple reversing induction motors including a stationary stator and multiple induction rotors attached to the main wheel that eliminate electrical slip rings or mechanical linkages as controls for effecting the rotation of the objects from the first to the second position.Type: GrantFiled: December 10, 1986Date of Patent: October 11, 1988Assignee: Abbott LaboratoriesInventors: Donald P. Martin, T. Edward Black, Vidas P. Kazlauskas
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Patent number: 4772377Abstract: A membrane anchor for an ion-selective electrode may be formed by intersolubilizing an ion-selective membrane lying above a sensing pad with a region of thermoplastic material laterally disposed around the membrane. A first layer of electrically insulating thermoset material lies beneath the thermoplastic material and in intimate contact with an electrically insulating substrate. A second layer of exposed thermoset material lies above the thermoplastic material and contacts the first layer of thermoset material around the entire lateral perimeter of the thermoset material.The membrane anchor may be usefully employed with an ion-selective electrode having an electrically insulating substrate with a substantially planar surface and having non-metallic means for sensing a potential affixed to the surface beneath an ion-sensitive membrane.Type: GrantFiled: May 22, 1987Date of Patent: September 20, 1988Assignee: Abbott LaboratoriesInventors: Jill M. Geist, Thomas G. Schapira
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Patent number: 4771429Abstract: A circuit is disclosed which combines the functions of a cyclic redundancy check code (CRCC) generator and a pseudo-random number generator in such a way that common elements are shared rather than duplicated. A 16-stage shift register and two linear feedback paths are included for the CRCC and pseudo-random number generators. A control section of the circuit controls the mode of operation of the circuit according to the state of a mode control signal. A signal on a clear line resets the shift register or initializes it with a selected value depending on the state of the mode control signal. The mode control signal also controls the input of data on a data line and the output of generated CRC and pseudo-random access codes on output lines.Type: GrantFiled: September 18, 1986Date of Patent: September 13, 1988Assignee: Abbott LaboratoriesInventors: Charles L. Davis, Jerry R. Sanders, James A. Rench
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Patent number: 4765843Abstract: A process for preventing contamination of a reagent system by a reagent delivery system. The process is suitable for performing an iron determination of a sample which prevents iron contamination of the sample from metal or iron-containing surfaces contained within the apparatus used to perform the iron assay. The process comprises pretreatment of the reagent delivery system surfaces with a silane solution and then washing the pretreated surfaces with water to remove any excess silane solution. Generally, the silane solution is an organosilane solution which can be an emulsion.Type: GrantFiled: April 28, 1987Date of Patent: August 23, 1988Assignee: Abbott LaboratoriesInventors: Sue K. Pierce, Jack B. Robinson, Jr., Ruth R. Scoggin
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Patent number: 4560558Abstract: Disclosed are compounds of the formula: ##STR1## wherein X is hydrogen, loweralkyl, loweralkoxy or halo, Y is hydroxymethyl, carboxyl, carboxamido or carboloweralkoxy, and R is cyclohexyl, benzyl, norbornyl, loweralkyl, or a pharmaceutically acceptable salt thereof.The compounds are effective as diuretic agents.Type: GrantFiled: May 16, 1983Date of Patent: December 24, 1985Assignee: Abbott LaboratoriesInventors: James A. Parks, Jacob J. Plattner
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Patent number: 4558010Abstract: The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.Type: GrantFiled: September 7, 1982Date of Patent: December 10, 1985Assignee: Abbott LaboratoriesInventors: Paul P. Hung, Shaw-Guang Lee, Ranajit Roychoudhury, Barry J. Ratzkin
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Patent number: D295025Type: GrantFiled: August 5, 1985Date of Patent: April 5, 1988Assignee: Abbott LaboratoriesInventor: James A. Vaught