Abstract: A composition containing a plurality of multicellular vesicles and at least one nucleic acid, at least one part of which is found included inside the multilamellar vesicles. Each of the vesicles is formed of a succession of lamellar bi-layers extending from each vesicle center to its periphery and including at least one surfactant agent. The bi-layers are concentric and are separated by a liquid medium. Such compositions can be used in pharmaceutics, particularly gene therapy, and in in vitro and in vivo transfection.
Type:
Grant
Filed:
January 6, 1999
Date of Patent:
May 14, 2002
Assignee:
Capsulis
Inventors:
Patrick Mahy, Didier Roux, René Laversanne, Joëlle Amedee, OLivier Freund